Discovering patterns of pleiotropy in genome-wide association studies

Autor: Harold Snieder, Moritz F. Sinner, Daniel F. Gudbjartsson, Niek Verweij, PM Pramstaller, B. D. Mitchell, Stephan B. Felix, Elsayed Z. Soliman, R. J. F. Loos, T.B. Harris, Mika Kähönen, Philipp S. Wild, Christy L. Avery, Kirill V. Tarasov, Stefania Bandinelli, Stefan Kääb, Tim D. Spector, Patrick T. Ellinor, David J. Stott, Renate B. Schnabel, Igor Rudan, O Polasekd, Brendan M. Buckley, Thomas Meitinger, James F. Wilson, Honghuang Lin, Gandin Ilaria, CM Duijn van, James P. Brody, L. J. Launer, Xiaoyan Yin, Ritchie, CT Aldana Silva, Paolo Gasparini, Dan M. Roden, Diane M. Crawford, Eric Boerwinkle, Davíð O. Arnar, Annette Peters, Caroline Hayward, Ilja M. Nolte, Terho Lehtimäki, Joop Jukema, Pi Bakker de, Thomas Münzel, Steven R. Cummings, Henry Völzke, Peter W. Macfarlane, John Barnard, Fabiola M Del Greco, Dan E. Arking, Anna F. Dominiczak, Patricia B. Munroe, Jonathan D. Smith, Anne M. Butler, Bruno H. Stricker, Stefan Blankenberg, Pv Harst der, S. Ulivi, Jerome I. Rotter, Hilma Holm, Alvaro Alonso, Haonan Lin, Gianfranco Sinagra, Alexander Teumer, Q Gibson, Bruce M. Psaty, Uwe Völker, Olli T. Raitakari, Annamaria Iorio, Bouwe P. Krijthe, Lude Franke, Folkert W. Asselbergs, Jared W. Magnani, G. Ehret, Susan R. Heckbert, L Ferrucci, Edward G. Lakatta, N. Sotoodehnia, Harry Campbell, Toshiko Tanaka, Wagoner van, JS Baderab, Yalda Jamshidi, Daniel S. Evans, David Schlessinger, Kari Stefansson, Nilesh J. Samani, Martina Müller-Nurasyid, Mark Eijgelsheim, Vilmundar Gudnason, Brenton R. Swenson, Sina A. Gharib, Kathleen F. Kerr, Josh C. Denny, Maristella Steri, E J Benjamin, George J. Papanicolaou, Unnur Thorsteinsdottir, Ivana Kolcic, Yuki Bradford, Mina K. Chung, Yongmei Liu, M. Waldenberger, Stella Trompet, Hoed, Jv Setten, Tanja Zeller, Jan A. Kors, Francesco Cucca, Irene Mateo Leach, A.G. Uitterlinden, Albert V. Smith, Craig Muller, Andrew A. Hicks, A Isaacs, Leo-Pekka Lyytikäinen, Konstantin Strauch, Steven A. Lubitz, Antonietta Robino, J Zhana, A. Pfeufer, Sandosh Padmanabhan, Afshin Parsa, Harm-Jan Westra, Marcus Dörr, J. C. Bis

MotivationGenome-wide association studies have had great success in identifying human genetic variants associated with disease, disease risk factors, and other biomedical phenotypes. Many variants are associated with multiple traits, even after corre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65cf9baa34e7b6179a637df32f0b4ee7
https://doi.org/10.1101/273540

Brain Volume as an Integrated Marker for the Risk of Death in a Community-Based Sample: Age Gene/Environment Susceptibility--Reykjavik Study

Autor: Qian Zhang, Palmi V. Jonsson, Sigudur Sigurdsson, Saskia G. C. van Elderen, Thaddeus J. Haight, Lenore J. Launer, Tamara B. Harris, Gudny Eiriksdottir, Melissa Garcia, Oscar L. Lopez, Laura W. de Jong, Mark A. van Buchem, Vilmundar Gudnason

Publikováno v: Journal of Gerontology: Medical Sciences, 71(1), 131-137

Background. T otal brain volume is an integrated measure of health and may be an independent indicator of mortality risk independent of any one clinical or subclinical disease state. We investigate the association of brain volume to total and cause-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eaf5552566b9811486dc8280a32077f
https://pubmed.ncbi.nlm.nih.gov/25359930