Výsledky vyhledávání - "Vilmos Csizmadia"

Preclinical Characterization of Vadadustat (AKB-6548), an Oral Small Molecule Hypoxia-Inducible Factor Prolyl-4-Hydroxylase Inhibitor, for the Potential Treatment of Renal Anemia

Autor: Anna Zuk, Zhihai Si, Sally Loi, Santhosh Bommegowda, Debie Hoivik, Sanjay Danthi, Gyongyi Molnar, Vilmos Csizmadia, Michael Rabinowitz

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 383:11-24

Pharmacological inhibition of prolyl-4-hydroxylase domain (PHD) enzymes stabilizes hypoxia-inducible factors (HIFs), transcription factors that activate target genes that, among others, increase erythropoietin (EPO) synthesis, resulting in the produc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::212ebca1120f2d693be7ff991a9b7695
https://doi.org/10.1124/jpet.122.001126

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Fasiglifam (TAK-875) Alters Bile Acid Homeostasis in Rats and Dogs: A Potential Cause of Drug Induced Liver Injury

Autor: Martin Paton, Mingxiang Liao, Patrick Kirby, Shaoxia Yu, Takuya Ebihara, Francis S. Wolenski, Andy Z. X. Zhu, Yvonne P. Dragan, Majid Vakilynejad, Christopher Gemski, Swapan Chowdhury, Jessica L. Grieves, Vilmos Csizmadia, Liping Pan, Yuu Moriya, Mike Johnson

Publikováno v: Toxicological Sciences

Fasiglifam (TAK-875), a Free Fatty Acid Receptor 1 (FFAR1) agonist in development for the treatment of type 2 diabetes, was voluntarily terminated in phase 3 due to adverse liver effects. A mechanistic investigation described in this manuscript focus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef2d7dea0c797e1eeb551fd9505608aa
http://europepmc.org/articles/PMC5414857

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Proteasome inhibitors bortezomib and carfilzomib used for the treatment of multiple myeloma do not inhibit the serine protease HtrA2/Omi

Autor: Paul Hales, Joseph J. Senn, Francis S. Wolenski, Christopher Tsu, Fleming Paul E, V Kadambi, Larry Dick, Jiejin Chen, Pooja Shah, Vilmos Csizmadia, Jingya Ma

Publikováno v: Toxicology Research. 5:1619-1628

The proteasome inhibitor bortezomib is associated with the development of peripheral neuropathy in patients, but the mechanism by which bortezomib can induce peripheral neuropathy is not fully understood. One study suggested that off-target inhibitio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0173538061f7b4bc95eb0e11866e5f99
https://doi.org/10.1039/c6tx00220j

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Antagonizing the alpha(4)beta(1) Integrin, but Not alpha(4)beta(7), Inhibits Leukocytic Infiltration of the Central Nervous System in Rhesus Monkey Experimental Autoimmune Encephalomyelitis

Autor: Krista G. Haanstra, Erwin L. A. Blezer, Tim Wyant, Vilmos Csizmadia, Sam O. Hofman, Li-Li Yang, Dave M. Lopes Estevao, Eric R. Fedyk, Jan Bauer, Bert A. 't Hart

Publikováno v: Journal of Immunology, 190(5), 1961-1973. AMER ASSOC IMMUNOLOGISTS

The immune system is characterized by the preferential migration of lymphocytes through specific tissues (i.e., tissue tropism). Tissue tropism is mediated, in part, by the alpha(4) integrins expressed by T lymphocytes. The alpha(4)beta(1) integrin m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2828a30e1b13fa3badc42ad60b48d7
https://hdl.handle.net/11370/c02caf9c-c7d7-4b85-80cc-496c537c2dd1

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Exclusive antagonism of the α4β7 integrin by vedolizumab confirms the gut-selectivity of this pathway in primates

Autor: Tim Wyant, Vilmos Csizmadia, Kristin E. Burke, V Kadambi, Li-Li Yang, Hua Yang, Eric R. Fedyk

Publikováno v: Inflammatory Bowel Diseases. 18:2107-2119

Background: Biological therapies that antagonize specific molecules have demonstrated efficacy in inflammatory bowel diseases, but infections resulting from systemic immunosuppression underscore the need for safer therapies. The objective of this inv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10408a832a798aca1c4330b914481c9c
https://doi.org/10.1002/ibd.22940

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Effect of Proteasome Inhibitors With Different Chemical Structures on the Ubiquitin–Proteasome System In Vitro

Autor: K. Cardoza, Vivek J. Kadambi, Arek Raczynski, E. Csizmadia, Lee Silverman, Carl L. Alden, Eric R. Fedyk, Chris Simpson, L. O’Brien, M. Gallacher, Vilmos Csizmadia

Publikováno v: Veterinary Pathology. 47:358-367

Proteasome inhibitor therapeutics (PITs) have the potential to cause peripheral neuropathy. In a mouse model of PIT-induced peripheral neuropathy, the authors demonstrated that ubiquitin-positive multifocal protein aggregates with nuclear displacemen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24df9ee8e455b58228e0c514deddd729
https://doi.org/10.1177/0300985809358423

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Effect of an experimental proteasome inhibitor on the cytoskeleton, cytosolic protein turnover, and induction in the neuronal cells in vitro

Autor: Arek Raczynski, Eva Csizmadia, Eric R. Fedyk, Carl L. Alden, James B. Rottman, Vilmos Csizmadia

Publikováno v: NeuroToxicology. 29:232-243

GT-1 murine neuronal cells exposed to an experimental proteasome inhibitor (EPI) for 24h showed increased cell death via a non-apoptotic mechanism, as assessed by TUNEL and DNA fragmentation assays. Immunofluorescence staining demonstrated that EPI i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c3187c62b62ea129a2a518965017670
https://doi.org/10.1016/j.neuro.2007.11.003

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BENEFICIAL EFFECTS OF TARGETING CCR5 IN ALLOGRAFT RECIPIENTS1

Autor: Theodore M. Danoff, Vilmos Csizmadia, Kerrie L. Faia, Stephen T. Smiley, Dulce Soler, Wei Gao, Jennifer A. King, Wayne W. Hancock

Publikováno v: Transplantation. 72:1199-1205

BACKGROUND The chemokine receptor, CCR5, and its three high-affinity ligands, macrophage inflammatory protein- (MIP) 1alpha, MIP-1beta, and regulated on activation normal T cell expressed and secreted (RANTES), are expressed by infiltrating mononucle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7ca7e084162f248c7b9739082e570617
https://doi.org/10.1097/00007890-200110150-00003

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DIFFERENTIAL NF-??B AND I??B GENE EXPRESSION DURING DEVELOPMENT OF CARDIAC ALLOGRAFT REJECTION VERSUS CD154 MONOCLONAL ANTIBODY-INDUCED TOLERANCE1

Autor: Wei Gao, Saege Hancock, James B. Rottman, Ulrich Siebenlist, Vilmos Csizmadia, Wayne W. Hancock, Zihao Wu, Laurence A. Turka

Publikováno v: Transplantation. 71:835-840

BACKGROUND The Rel/NF-kappaB transcription factor pathway, regulated by IkappaB proteins, is considered central to immune responses, although there are surprisingly few in vivo data concerning alloresponses. METHODS We undertook analysis of NF-kappaB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::974372372cda82a4203b301049f6dfeb
https://doi.org/10.1097/00007890-200104150-00003

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Donor-Derived Ip-10 Initiates Development of Acute Allograft Rejection

Autor: Wayne W. Hancock, Kerrie L. Faia, Nida Shemmeri, Wei Gao, Vilmos Csizmadia, Andrew D. Luster

Publikováno v: The Journal of Experimental Medicine

An allograft is often considered an immunologically inert playing field on which host leukocytes assemble and wreak havoc. However, we demonstrate that graft-specific physiologic responses to early injury initiate and promulgate destruction of vascul

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce21e921f22dd25410efbc32ffe89625
http://europepmc.org/articles/PMC2193411

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