Zobrazeno 1 - 10
of 93
pro vyhledávání: '"Vilmante, Borutaite"'
Publikováno v:
Biomedicines, Vol 12, Iss 10, p 2342 (2024)
Background and Objective: The alteration of mitochondrial functions, especially the opening of the mitochondrial permeability transition pore (mPTP), has been proposed as a key mechanism in the development of lesions in cerebral ischemia, wherefore i
Externí odkaz:
https://doaj.org/article/526bc97c91f44e5eb9c5a39f663aeb6a
Autor:
Katryna Pampuscenko, Ramune Morkuniene, Lukas Krasauskas, Vytautas Smirnovas, Guy C. Brown, Vilmante Borutaite
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract In tauopathies, abnormal deposition of intracellular tau protein followed by gradual elevation of tau in cerebrospinal fluids and neuronal loss has been documented, however, the mechanism how actually neurons die under tau pathology is large
Externí odkaz:
https://doaj.org/article/6bbc5d971c5b413b88366dc74ed4111c
Autor:
Aiste Jekabsone, Silvija Jankeviciute, Katryna Pampuscenko, Vilmante Borutaite, Ramune Morkuniene
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 15, p 12315 (2023)
Alzheimer’s disease (AD) is the most common form of dementia worldwide, and it contributes up to 70% of cases. AD pathology involves abnormal amyloid beta (Aβ) accumulation, and the link between the Aβ1-42 structure and toxicity is of major inter
Externí odkaz:
https://doaj.org/article/4be05f16f07347f79b2adab1819d4c7a
Autor:
Danielius Umbrasas, Odeta Arandarcikaite, Ramune Grigaleviciute, Rimantas Stakauskas, Vilmante Borutaite
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 18, p 9717 (2021)
Mitochondrial dysfunction during ischemic stroke ultimately manifests as ATP depletion. Mitochondrial ATP synthase upon loss of mitochondrial membrane potential during ischemia rapidly hydrolyses ATP and thus contributes to ATP depletion. Increasing
Externí odkaz:
https://doaj.org/article/6b41dc6e2f3e4bd8b33706df6fc2d733
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 17, p 9493 (2021)
Microglial functioning depends on Ca2+ signaling. By using Ca2+ sensitive fluorescence dye, we studied how inhibition of mitochondrial respiration changed spontaneous Ca2+ signals in soma of microglial cells from 5–7-day-old rats grown under normox
Externí odkaz:
https://doaj.org/article/14a20aa331534d90b4398399eb6c07bf
Publikováno v:
Data in Brief, Vol 13, Iss , Pp 707-712 (2017)
The data presented in this article are related to the research article entitled “Rotenone decreases ischemia-induced injury by inhibiting mitochondrial permeability transition in mature brains” (Rekuviene et al., 2017) [1]. Data in this article p
Externí odkaz:
https://doaj.org/article/665be739720e4ef588893f0b673a7d11
Autor:
Gintare Zemgulyte, Shigeru Tanaka, Izumi Hide, Norio Sakai, Katryna Pampuscenko, Vilmante Borutaite, Daiva Rastenyte
Publikováno v:
Pharmaceuticals, Vol 14, Iss 4, p 312 (2021)
Stroke is the second leading cause of death worldwide. Treatment options for ischemic stroke are limited, and the development of new therapeutic agents or combined therapies is imperative. Growing evidence suggests that metformin treatment, due to it
Externí odkaz:
https://doaj.org/article/24b066560a21425293be75f3b7ddcec6
Autor:
Kristina Skemiene, Evelina Rekuviene, Aiste Jekabsone, Paulius Cizas, Ramune Morkuniene, Vilmante Borutaite
Publikováno v:
Biomolecules, Vol 10, Iss 10, p 1400 (2020)
Damage to cerebral mitochondria, particularly opening of mitochondrial permeability transition pore (MPTP), is a key mechanism of ischemic brain injury, therefore, modulation of MPTP may be a potential target for a neuroprotective strategy in ischemi
Externí odkaz:
https://doaj.org/article/5cfb2db63abe48c1882ec6b2368b7f71
Publikováno v:
Free radical biology & medicine, 165, 24-37. Elsevier Inc.
The heart is the most metabolically flexible organ with respect to the use of substrates available in different states of energy metabolism. Cardiac mitochondria sense substrate availability and ensure the efficiency of oxidative phosphorylation and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9167f2afdcef17cbb4f3bdcdbf4b001
https://doi.org/10.1016/j.freeradbiomed.2021.01.036
https://doi.org/10.1016/j.freeradbiomed.2021.01.036
Autor:
Gintaras Valincius, Ramune Morkuniene, Rima Budvytyte, Tomas Sneideris, Katryna Pampuscenko, Vytautas Smirnovas, Guy C. Brown, Vilmante Borutaite
Publikováno v:
Journal of Neurochemistry, Hoboken : Wiley, 2020, vol. 154, no. 3, art. no. 14940, p. 316-329
Tau is a microtubule-associated protein, found at high levels in neurons, and the aggregation of which is associated with neurodegeneration. Recently it was found that tau can be actively secreted from neurons, but the effects of extracellular tau on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab1f51e94f0149f2a665e6dfa481244
https://doi.org/10.1111/jnc.14940
https://doi.org/10.1111/jnc.14940