Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Vilma Schonmann"'
Publikováno v:
Developmental Neuroscience. 25:50-64
The Notch1 pathway plays a fundamental role during the establishment of cell fates in the central nervous system (CNS) by regulating neural cell differentiation. In oligodendrocytes (OLs), Notch1 activity prevents these cells from becoming terminally
Autor:
Rui M. Costa, Maria I. Givogri, Ernesto R. Bongarzone, Anthony T. Campagnoni, Alcino J. Silva, Vilma Schonmann
Publikováno v:
Journal of Neuroscience Research. 67:309-320
Activity of the Notch1 gene is known to inhibit oligodendrocyte (OL) differentiation in vitro. We tested the hypothesis that the Notch1 pathway regulates in vivo myelin formation, by examining brain myelination of Notch1 receptor null heterozygotes m
Autor:
Kathy Kampf, Vilma Schonmann, Erin C. Jacobs, Ernesto R. Bongarzone, Anthony T. Campagnoni, Celia W. Campagnoni
Publikováno v:
Journal of Neuroscience Research. 65:485-492
The proteolipid (PLP) gene encodes at least four proteins, including the classic PLP and DM20, which are important components of the myelin sheath, and the recently identified soma-restricted (sr) isoforms, srPLP and srDM20. The classic PLP and DM20
Publikováno v:
Journal of Neuroscience Research. 65:477-484
The myelin proteolipid (PLP) gene is very active in oligodendrocytes (OLs) and generates at least four proteins: the classic PLP and DM20 proteolipids, which are associated with compact myelin and the srPLP and srDM20, which are associated with the c
Autor:
Anthony T. Campagnoni, Vilma Schonmann, Ernesto R. Bongarzone, Sujatha Byravan, Maria I. Givogri
Publikováno v:
Journal of Neuroscience Research. 62:319-328
We generated a new cell line, N38, by conditionally immortalizing mouse oligodendrocytes (OLs) at early stages of maturation. The morphology and marker expression pattern suggest N38 cells are similar to immature OLs. N38 cells were sensitive to chan
Autor:
Celia W. Campagnoni, Erin C. Jacobs, Anthony T. Campagnoni, Ernesto R. Bongarzone, Kathy Kampf, Vilma Schonmann, Vance Handley
Publikováno v:
The Journal of Neuroscience. 19:8349-8357
The myelin proteolipid protein (PLP) gene (i.e., the PLP/DM20 gene) has been of some interest because of its role in certain human demyelinating diseases, such as Pelizaeus-Merzbacher disease. A substantial amount of evidence, including neuronal path
Autor:
Ernesto R. Bongarzone, Vilma Schonmann, P. Casaccia-Bonnefil, Anthony T. Campagnoni, Sujatha Byravan, Lyndon M. Foster
Publikováno v:
Journal of Neuroscience Research. 54:309-319
We have generated two conditionally immortalized neuronal cell lines from primary cultures of embryonic day 13 (E13) and postmitotic (postnatal day 0; P0) cortical neurons transformed with the temperature-sensitive SV-40 large-T antigen. Two clonal c
Publikováno v:
The Journal of Neuroscience. 18:5344-5353
Expression of the dopamine D3 receptor (D3r) was found in primary mixed glial cultures from newborn brain and in the corpus callosumin vivoduring the peak of myelination. Expression of the D3r mRNA, but not D2r mRNA, was detected as early as 5 din vi
Publikováno v:
Developmental Neuroscience. 19:143-151
Translocation of mRNAs has emerged as an important form of protein targeting. In oligodendrocytes, the myelin-forming cells of the central nervous system, myelin basic protein (MBP) mRNAs are transported into cell processes and the cytoplasmic channe
Autor:
George Harauz, Jeffery D. Haines, L.A. Wellhauser, Vilma Schonmann, Lillian S. DeBruin, G. Radeva, Dorothee Bienzle
Publikováno v:
Journal of neuroscience research. 80(2)
Specific membrane microdomains (including lipid rafts) exist in myelin but have not been fully characterized. Myelin basic protein (MBP) maintains the compactness of the myelin sheath and is highly posttranslationally modified. Thus, it has been sugg