Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Ville J. Kujala"'
Autor:
Lorna Ewart, Athanasia Apostolou, Skyler A. Briggs, Christopher V. Carman, Jake T. Chaff, Anthony R. Heng, Sushma Jadalannagari, Jeshina Janardhanan, Kyung-Jin Jang, Sannidhi R. Joshipura, Mahika M. Kadam, Marianne Kanellias, Ville J. Kujala, Gauri Kulkarni, Christopher Y. Le, Carolina Lucchesi, Dimitris V. Manatakis, Kairav K. Maniar, Meaghan E. Quinn, Joseph S. Ravan, Ann Catherine Rizos, John F. K. Sauld, Josiah D. Sliz, William Tien-Street, Dennis Ramos Trinidad, James Velez, Max Wendell, Onyi Irrechukwu, Prathap Kumar Mahalingaiah, Donald E. Ingber, Jack W. Scannell, Daniel Levner
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-16 (2022)
Ewart et al. assess the performance of a human Liver-Chip for predictive toxicology. They also perform an economic analysis to demonstrate its potential financial value for the pharmaceutical industry.
Externí odkaz:
https://doaj.org/article/8af1884ce4df43869295c061cce05605
Autor:
Lorna Ewart, Athanasia Apostolou, Skyler A. Briggs, Christopher V. Carman, Jake T. Chaff, Anthony R. Heng, Sushma Jadalannagari, Jeshina Janardhanan, Kyung-Jin Jang, Sannidhi R. Joshipura, Mahika M. Kadam, Marianne Kanellias, Ville J. Kujala, Gauri Kulkarni, Christopher Y. Le, Carolina Lucchesi, Dimitris V. Manatakis, Kairav K. Maniar, Meaghan E. Quinn, Joseph S. Ravan, Ann Catherine Rizos, John F. K. Sauld, Josiah D. Sliz, William Tien-Street, Dennis Ramos Trinidad, James Velez, Max Wendell, Onyi Irrechukwu, Prathap Kumar Mahalingaiah, Donald E. Ingber, Jack W. Scannell, Daniel Levner
Publikováno v:
Communications Medicine, Vol 3, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/5e27c6f2cc2e4fe0a5530d0d36badbf6
Autor:
Anna L. Lahti, Ville J. Kujala, Hugh Chapman, Ari-Pekka Koivisto, Mari Pekkanen-Mattila, Erja Kerkelä, Jari Hyttinen, Kimmo Kontula, Heikki Swan, Bruce R. Conklin, Shinya Yamanaka, Olli Silvennoinen, Katriina Aalto-Setälä
Publikováno v:
Disease Models & Mechanisms, Vol 5, Iss 2, Pp 220-230 (2012)
SUMMARY Long QT syndrome (LQTS) is caused by functional alterations in cardiac ion channels and is associated with prolonged cardiac repolarization time and increased risk of ventricular arrhythmias. Inherited type 2 LQTS (LQT2) and drug-induced LQTS
Externí odkaz:
https://doaj.org/article/4cc60259a6974a38becc0e0ca2a95b62
Autor:
Anna Herland, Ben Swenor, Daniel Levner, Olivier Y.F. Henry, Sasan Jalili-Firoozinezhad, Angeliki Chalkiadaki, Henry Sanchez, Andrzej Przekwas, Sauveur S. F. Jeanty, Rachelle Prantil-Baun, Josiah Sliz, Youngjae Choe, Kyung-Jin Jang, Moran Yadid, Susan Marquez, Chris Hinojosa, Thomas C. Ferrante, Blakely B. O'Connor, Tiama Hamkins-Indik, Rachel Fleming, Stephanie Dauth, Janna Nawroth, Morgan Burt, Ben M. Maoz, David B. Chou, Aaron Delahanty, John P. Ferrier, Anthony Bahinski, Jose Fernandez-Alcon, Bret Nestor, Guy Robert Thompson, Lian Leng, Robert Mannix, Michael J. Cronce, Yuka Milton, Mahadevabharath R. Somayaji, Alexandra Sontheimer-Phelps, Tae-Eun Park, Miles Ingram, Edward A. FitzGerald, Debarun Das, Ville J. Kujala, Josue A. Goss, George J. Touloumes, Toni Divic, Carlos F. Ng, Oren Levy, Zachary Tranchemontagne, Elizabeth Calamari, Geraldine A. Hamilton, Alexander Cho, Thomas Grevesse, Norman Wen, Tessa Huffstater, Donald E. Ingber, Kevin Kit Parker, Richard M. Novak
Publikováno v:
Nature Biomedical Engineering. 4:407-420
Organ chips can recapitulate organ-level (patho)physiology, yet pharmacokinetic and pharmacodynamic analyses require multi-organ systems linked by vascular perfusion. Here, we describe an 'interrogator' that employs liquid-handling robotics, custom s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea94accc104e59d5af0303d98dc1c94f
https://doi.org/10.1038/s41551-019-0497-x
https://doi.org/10.1038/s41551-019-0497-x
Autor:
Lorna Ewart, Athanasia Apostolou, Skyler A. Briggs, Christopher V. Carman, Jake T. Chaff, Anthony R. Heng, Sushma Jadalannagari, Jeshina Janardhanan, Kyung-Jin Jang, Sannidhi R. Joshipura, Mahika M. Kadam, Marianne Kanellias, Ville J. Kujala, Gauri Kulkarni, Christopher Y. Le, Carolina Lucchesi, Dimitris V. Manatakis, Kairav K. Maniar, Meaghan E. Quinn, Joseph S. Ravan, Ann Catherine Rizos, John F.K. Sauld, Josiah D. Sliz, William Tien-Street, Dennis Ramos Trinidad, James Velez, Max Wendell, Onyi Irrechukwu, Prathap Kumar Mahalingaiah, Donald E. Ingber, Jack W. Scannell, Daniel Levner
Human organ-on-a-chip (Organ-Chip) technology has the potential to disrupt preclinical drug discovery and improve success in drug development pipelines as it can recapitulate organ-level pathophysiology and clinical responses. The Innovation and Qual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a356d70f36120aa259a4974531c27107
https://doi.org/10.1101/2021.12.14.472674
https://doi.org/10.1101/2021.12.14.472674
Autor:
Christopher Carman, Marianne Kanellias, Dennis Ramos, Kairav Maniar, John Saud, Carolina Lucchesi, Gauri Kulkarni, Athanasia Apostulou, Ville J Kujala, Lorna Ewart
Publikováno v:
The Journal of Immunology. 208:116.13-116.13
Objective Immune cell recruitment into tissues is an essential step in inflammatory responses. This occurs in a highly tissue- and stimulus-specific manner, which presents a significant challenge to modeling disease and testing therapeutics ex vivo.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7d9327fbd40032861d20c066e3dd120
https://doi.org/10.4049/jimmunol.208.supp.116.13
https://doi.org/10.4049/jimmunol.208.supp.116.13
Autor:
Min-Joon Han, Deniz Cataltepe, Kellen D. Winden, Clifford J. Woolf, Daria Turner, Mustafa Sahin, Mary E. Hatten, Ville J. Kujala, David E. Buchholz, Kush Kapur, Ivan Tochitsky, Maria Sundberg
Publikováno v:
Molecular psychiatry
Accumulating evidence suggests that cerebellar dysfunction early in life is associated with autism spectrum disorder (ASD), but the molecular mechanisms underlying the cerebellar deficits at the cellular level are unclear. Tuberous sclerosis complex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87977593a76cd82aab6c28d06c24f9c2
http://europepmc.org/articles/PMC6093816
http://europepmc.org/articles/PMC6093816
Autor:
John M. Doyle, William D. Leineweber, Ben M. Maoz, Moran Yadid, Anna Herland, Olivier Y.F. Henry, Edward A. FitzGerald, Donald E. Ingber, Ville J. Kujala, Robert Mannix, Kevin Kit Parker
Publikováno v:
Lab on a Chip. 17:2294-2302
Here we demonstrate that microfluidic cell culture devices, known as Organs-on-a-Chips can be fabricated with multifunctional, real-time, sensing capabilities by integrating both multi-electrode arrays (MEAs) and electrodes for transepithelial electr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::772fdd09648ad156660e0e3779e685cd
https://doi.org/10.1039/c7lc00412e
https://doi.org/10.1039/c7lc00412e
Autor:
Ben M. Maoz, Sasan Jalili-Firoozinezhad, Andrzej Przekwas, Carlos F. Ng, Alexander Cho, Anna Herland, Jose Fernandez-Alcon, Daniel Levner, Olivier Y.F. Henry, Janna Nawroth, Blakely B. O'Connor, Debarun Das, David B. Chou, Kevin Kit Parker, Anthony Bahinski, Morgan Burt, Ville J. Kujala, Susan Clauson, Mahadevabharath R. Somayaji, Thomas C. Ferrante, Ben Swenor, Henry Sanchez, Lian Leng, Tessa Huffstater, Angeliki Chalkiadaki, Miles Ingram, Donald E. Ingber, Tiama Hamkins-Indik, Norman Wen, Rachelle Prantil-Baun, Youngjae Choe, Josiah Sliz, Zachary Tranchemontagne, Bret Nestor, George J. Touloumes, Rachel Fleming, Guy Robert Thompson, Alexandra Sontheimer-Phelps, Josue A. Goss, Oren Levy, Toni Divic, Elizabeth Calamari, Sauveur S. F. Jeanty, Kyung-Jin Jang, Michael J. Cronce, Yuka Milton, Richard M. Novak, Geraldine A. Hamilton, Thomas Grevesse, Chris Hinojosa, Moran Yadid, Stephanie Dauth, John P. Ferrier, Tae-Eun Park, Robert Mannix, Edward A. FitzGerald, Aaron Delahanty
Publikováno v:
Nat Biomed Eng
Here we describe of an ‘Interrogator’ instrument that uses liquid-handling robotics, a custom software package, and an integrated mobile microscope to enable automated culture, perfusion, medium addition, fluidic linking, sample collection, andin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91904c828996f1d91cb14b8c52e98514
https://doi.org/10.1101/569541
https://doi.org/10.1101/569541
Publikováno v:
Journal of Materials Chemistry B. 4:3534-3543
Pharmaceutical screening based on human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and multi electrode arrays (MEAs) have been proposed as a complementary method for electrophysiological safety and efficacy assessment in drug di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c24b5782f1d14a25e5829cfc62f4d725
https://doi.org/10.1039/c6tb00324a
https://doi.org/10.1039/c6tb00324a