Zobrazeno 1 - 10
of 75
pro vyhledávání: '"Ville Hietakangas"'
Autor:
Tom Barsby, Eliisa Vähäkangas, Jarkko Ustinov, Hossam Montaser, Hazem Ibrahim, Väinö Lithovius, Emilia Kuuluvainen, Vikash Chandra, Jonna Saarimäki-Vire, Pekka Katajisto, Ville Hietakangas, Timo Otonkoski
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112970- (2023)
Summary: Pancreatic islets regulate blood glucose homeostasis through the controlled release of insulin; however, current metabolic models of glucose-sensitive insulin secretion are incomplete. A comprehensive understanding of islet metabolism is int
Externí odkaz:
https://doaj.org/article/ce7f7f087e48409ea41c81a3c021754a
Autor:
Linda van den Berg, Krista Kokki, Sylvia J. Wowro, Konstantin M. Petricek, Onur Deniz, Catrin A. Stegmann, Marius Robciuc, Mari Teesalu, Richard G. Melvin, Anni I. Nieminen, Michael Schupp, Ville Hietakangas
Publikováno v:
Cell Reports, Vol 42, Iss 7, Pp 112739- (2023)
Summary: The ability to feed on a sugar-containing diet depends on a gene regulatory network controlled by the intracellular sugar sensor Mondo/ChREBP-Mlx, which remains insufficiently characterized. Here, we present a genome-wide temporal clustering
Externí odkaz:
https://doaj.org/article/65971c572d3b492db9e0387223bacef0
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 8, Pp 2843-2849 (2020)
Insulin/insulin-like growth factor signaling (IIS) is a conserved mechanism to regulate animal physiology in response to nutrition. IIS activity controls gene expression, but only a subset of transcriptional regulators (TRs) targeted by the IIS pathw
Externí odkaz:
https://doaj.org/article/d6eb4caf56c241d3a663358a11b514ac
Autor:
Krista Kokki, Nicole Lamichane, Anni I Nieminen, Hanna Ruhanen, Jack Morikka, Marius Robciuc, Bohdana M Rovenko, Essi Havula, Reijo Käkelä, Ville Hietakangas
Publikováno v:
PLoS Genetics, Vol 17, Iss 10, p e1009855 (2021)
Nutrient-dependent gene regulation critically contributes to homeostatic control of animal physiology in changing nutrient landscape. In Drosophila, dietary sugars activate transcription factors (TFs), such as Mondo-Mlx, Sugarbabe and Cabut, which co
Externí odkaz:
https://doaj.org/article/71bd6816e9024bfd8d0a75273ba21b04
Autor:
Maria Sokolova, Henna M. Moore, Bina Prajapati, Joseph Dopie, Leena Meriläinen, Mikko Honkanen, Rita Cerejeira Matos, Minna Poukkula, Ville Hietakangas, Maria K. Vartiainen
Publikováno v:
iScience, Vol 9, Iss , Pp 63-70 (2018)
Summary: Actin has been linked to processes spanning the whole gene expression cascade, from regulating specific transcription factors, such as myocardin-related transcription factor, to chromatin remodeling and RNA polymerase function. However, whet
Externí odkaz:
https://doaj.org/article/0377805f70d5493dbdd210059f1f9fdb
Autor:
Cagri Yalgin, Bohdana Rovenko, Ana Andjelković, Margot Neefjes, Burak Oymak, Eric Dufour, Ville Hietakangas, Howard T. Jacobs
Publikováno v:
iScience, Vol 23, Iss 8, Pp 101362- (2020)
Summary: Dopaminergic (DA) neurons have been implicated as key targets in neurological disorders, notably those involving locomotor impairment, and are considered to be highly vulnerable to mitochondrial dysfunction, a common feature of such diseases
Externí odkaz:
https://doaj.org/article/002f6f5a2ec14c7b8032eb8cfdb084db
Publikováno v:
Biology Open, Vol 7, Iss 11 (2018)
PWP1 is a chromatin binding protein with an important role in animal growth control downstream of mTOR-mediated nutrient sensing. PWP1 has been shown to control tissue growth by promoting the transcription of 5.8S, 18S and 28S ribosomal RNAs (rRNAs)
Externí odkaz:
https://doaj.org/article/c419a54fdfea4736a361d72525e8e26b
Autor:
Richard G Melvin, Nicole Lamichane, Essi Havula, Krista Kokki, Charles Soeder, Corbin D Jones, Ville Hietakangas
Publikováno v:
eLife, Vol 7 (2018)
How dietary selection affects genome evolution to define the optimal range of nutrient intake is a poorly understood question with medical relevance. We have addressed this question by analyzing Drosophila simulans and sechellia, recently diverged sp
Externí odkaz:
https://doaj.org/article/f7164d3e3229475fa72fb355a09975d8
Autor:
Jaakko Mattila, Essi Havula, Erja Suominen, Mari Teesalu, Ida Surakka, Riikka Hynynen, Helena Kilpinen, Juho Väänänen, Iiris Hovatta, Reijo Käkelä, Samuli Ripatti, Thomas Sandmann, Ville Hietakangas
Publikováno v:
Cell Reports, Vol 13, Iss 2, Pp 350-364 (2015)
The ChREBP/Mondo-Mlx transcription factors are activated by sugars and are essential for sugar tolerance. They promote the conversion of sugars to lipids, but beyond this, their physiological roles are insufficiently understood. Here, we demonstrate
Externí odkaz:
https://doaj.org/article/bc787bf3a50e4994b72aac3c86df2c22
Autor:
Kiran Hasygar, Ville Hietakangas
Publikováno v:
PLoS Genetics, Vol 10, Iss 11, p e1004764 (2014)
Insulin-like signalling is a conserved mechanism that coordinates animal growth and metabolism with nutrient status. In Drosophila, insulin-producing median neurosecretory cells (IPCs) regulate larval growth by secreting insulin-like peptides (dILPs)
Externí odkaz:
https://doaj.org/article/9a187b9d49064dbea14767a8b2c78198