Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Ville Eskonen"'
Publikováno v:
ACS Omega, Vol 4, Iss 15, Pp 16501-16507 (2019)
Externí odkaz:
https://doaj.org/article/29170cabf2e942eebfff265169475677
Publikováno v:
ACS Omega, Vol 4, Iss 2, Pp 4269-4275 (2019)
Externí odkaz:
https://doaj.org/article/d068f18412194e6399e98b0df6ee323e
Autor:
Salla Valtonen, Emmiliisa Vuorinen, Ville Eskonen, Morteza Malakoutikhah, Kari Kopra, Harri Härmä
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
Protein aggregation is a spontaneous process affected by multiple external and internal properties, such as buffer composition and storage temperature. Aggregation of protein-based drugs can endanger patient safety due, for example, to increased immu
Externí odkaz:
https://doaj.org/article/3faa2234daa44908bdbbbd5ac19c4d0b
Autor:
Anssi Peuronen, Henri Kivelä, Pasi Salonen, Ville Eskonen, Marta Karman, Manu Lahtinen, Grzegorz Romanowski, Ari Lehtonen
Publikováno v:
Inorganica Chimica Acta. 553:121519
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0699ae4f52668d9797e9684054f43a0
https://doi.org/10.1016/j.ica.2023.121519
https://doi.org/10.1016/j.ica.2023.121519
Autor:
John Le Quesne, Emmiliisa Vuorinen, Taru Kariniemi, Martin Bushell, Salla Valtonen, Kari Kopra, Ville Eskonen, Harri Härmä
Publikováno v:
Analytical Chemistry
Protein–protein interactions (PPIs) are an essential part of correct cellular functionality, making them increasingly interesting drug targets. While Förster resonance energy transfer-based methods have traditionally been widely used for PPI studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f209a068d93389ee69c6609f02513e1
https://doi.org/10.1021/acs.analchem.0c02823
https://doi.org/10.1021/acs.analchem.0c02823
Autor:
Moona Miettinen, Leena Mattsson, Natalia Tong-Ochoa, Mika Lastusaari, Kari Kopra, Arto T. Pulliainen, Ville Eskonen, Harri Härmä
Publikováno v:
Analytical Chemistry
Post-translational modifications (PTMs) are one of the most important regulatory mechanisms in cells, and they play key roles in cell signaling both in health and disease. PTM catalyzing enzymes have become significant drug targets, and therefore, tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed4bb607386b7818df62f1b3cc851752
http://europepmc.org/articles/PMC7735653
http://europepmc.org/articles/PMC7735653
Publikováno v:
ACS Omega, Vol 4, Iss 15, Pp 16501-16507 (2019)
ACS Omega
ACS Omega
Post-translational modifications (PTMs) of proteins provide an important mechanism for cell signal transduction control. Impaired PTM control is a key feature in multiple different disease states, and thus the enzyme-controlling PTMs have drawn atten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f164e39394b10eb43ced43ad193d758
https://doaj.org/article/29170cabf2e942eebfff265169475677
https://doaj.org/article/29170cabf2e942eebfff265169475677
Publikováno v:
Analytica Chimica Acta. 1055:126-132
We have developed a rapid and sensitive universal peptide-based time-resolved luminescence assay for detection of enzymatic post-translational modifications (PTMs). PTMs play essential roles in intracellular signaling and cell regulation, thus provid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c07972c730388303808be7a9f2f9003
https://doi.org/10.1016/j.aca.2018.12.041
https://doi.org/10.1016/j.aca.2018.12.041
Publikováno v:
Analytical Biochemistry. 572:25-32
The KRAS gene is highly mutated in human cancers and the focus of current Ras drug development efforts. Recently the interface between the C-terminus of K-Ras and calmodulin (CaM) was proposed as a target site to block K-Ras driven cancer cell stemne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ea182a80726f76d07b7371f3771b37d
https://doi.org/10.1016/j.ab.2019.02.015
https://doi.org/10.1016/j.ab.2019.02.015
Publikováno v:
ACS Omega, Vol 4, Iss 2, Pp 4269-4275 (2019)
Protein post-translational modifications (PTMs) are typically enzyme-catalyzed events generating functional diversification of proteome; thus, multiple PTM enzymes have been validated as potential drug targets. We have previously introduced energy-tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2425f770ef55c8fed40b0cf8b0c3e2a1
http://juuli.fi/Record/0338271819
http://juuli.fi/Record/0338271819