Treatment of adult chronic indeterminate Chagas disease with benznidazole and three E1224 dosing regimens: a proof-of-concept, randomised, placebo-controlled trial

Autor: Santina, Glaucia, Blum, Bethania, Correia, Erika, Garcia-Bournisen, Facundo, Vaillant, Michel, Morales, Jimena Ramos, Pinto Rocha, Jimy Jose, Rojas Delgadillo, Gimena, Magne Anzoleaga, Helmut Ramon, Mendoza, Nilce, Quechover, Roxana Challapa, Caballero, Maria Yurly Escobar, Lozano Beltran, Daniel Franz, Zalabar, Albert Mendoza, Rojas Panozo, Lizeth, Palacios Lopez, Alejandro, Torrico Terceros, Dunia, Fernandez Galvez, Violeta Alejandra, Cardozo, Letty, Cuellar, Gabriela, Vasco Arenas, Rudy Nelson, Gonzales, Isabel, Hoyos Delfin, Carlos Florencio, Garcia, Lineth, Parrado, Rudy, de la Barra, Anabelle, Montano, Nair, Villarroel, Sandro, Duffy, Tomas, Bisio, Margarita, Ramirez, Juan Carlos, Duncanson, Fred, Everson, Michael, Daniels, Antonia, Asada, Makoto, Cox, Eugene, Wesche, David, Diderichsen, Paul Matthias, Marques, Alexandre F, Izquierdo, Luis, Sender, Silvia Sanz, Reverter, Joan Carlos, Morales, Manuel, Jimenez, Wladimiro, Torrico, Faustino, Gascon, Joaquim, Ortiz, Lourdes, Alonso-Vega, Cristina, Pinazo, María-Jesús, Schijman, Alejandro, Almeida, Igor C, Alves, Fabiana, Strub-Wourgaft, Nathalie, Ribeiro, Isabela

Publikováno v: In The Lancet Infectious Diseases April 2018 18(4):419-430

First external quality assurance program for bloodstream Real-Time PCR monitoring of treatment response in clinical trials of Chagas disease

Autor: Ramírez, Juan C., Parrado, Rudy, Sulleiro Igual, Elena, de la Barra, Anabelle, Rodríguez, Marcelo, Villarroel, Sandro, Irazu, Lucía, Alonso-Vega, Cristina, Alves, Fabiana, Curto, María A., García, Lineth, Ortiz, Lourdes, Torrico, Faustino, Gascon, Joaquim, Flevaud, Laurence, Molina Romero, Israel, Ribeiro, Isabela, Schijman, Alejandro G., Universitat Autònoma de Barcelona

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Recercat. Dipósit de la Recerca de Catalunya
instname
PLoS ONE
PLoS ONE, Vol 12, Iss 11, p e0188550 (2017)
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET

Real-Time PCR (qPCR) testing is recommended as both a diagnostic and outcome measurement of etiological treatment in clinical practice and clinical trials of Chagas disease (CD), but no external quality assurance (EQA) program provides performance as

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0171b8dc7c0e90f7dd1123f62bc824b
http://hdl.handle.net/2445/118791

Analytical Validation of Quantitative Real-Time PCR Methods for Quantification of Trypanosoma cruziDNA in Blood Samples from Chagas Disease Patients

Autor: Ramírez, Juan Carlos, Cura, Carolina Inés, da Cruz Moreira, Otacilio, Lages-Silva, Eliane, Juiz, Natalia, Velázquez, Elsa, Ramírez, Juan David, Alberti, Anahí, Pavia, Paula, Flores-Chávez, María Delmans, Muñoz-Calderón, Arturo, Pérez-Morales, Deyanira, Santalla, José, Marcos da Matta Guedes, Paulo, Peneau, Julie, Marcet, Paula, Padilla, Carlos, Cruz-Robles, David, Valencia, Edward, Crisante, Gladys Elena, Greif, Gonzalo, Zulantay, Inés, Costales, Jaime Alfredo, Alvarez-Martínez, Miriam, Martínez, Norma Edith, Villarroel, Rodrigo, Villarroel, Sandro, Sánchez, Zunilda, Bisio, Margarita, Parrado, Rudy, Maria da Cunha Galvão, Lúcia, Jácome da Câmara, Antonia Cláudia, Espinoza, Bertha, Alarcón de Noya, Belkisyole, Puerta, Concepción, Riarte, Adelina, Diosque, Patricio, Sosa-Estani, Sergio, Guhl, Felipe, Ribeiro, Isabela, Aznar, Christine, Britto, Constança, Yadón, Zaida Estela, Schijman, Alejandro G.

Publikováno v: The Journal of Molecular Diagnostics; September 2015, Vol. 17 Issue: 5 p605-615, 11p

Analytical Validation of Quantitative Real-Time PCR Methods for Quantification of Trypanosoma cruzi DNA in Blood Samples from Chagas Disease Patients.

Autor: Ramírez JC; Laboratory of Molecular Biology of Chagas Disease (LaBMECh), Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI-CONICET), Buenos Aires, Argentina., Cura CI; Laboratory of Molecular Biology of Chagas Disease (LaBMECh), Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI-CONICET), Buenos Aires, Argentina., da Cruz Moreira O; Laboratory of Molecular Biology of Endemic Diseases, Instituto Oswaldo Cruz/Fiocruz, Rio de Janeiro, Brazil., Lages-Silva E; Laboratory of Discipline of Parasitology, Universidade Federal do Triângulo Mineiro, Uberaba, Brazil., Juiz N; Laboratory of Molecular Biology of Chagas Disease (LaBMECh), Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI-CONICET), Buenos Aires, Argentina., Velázquez E; National Institute of Parasitology 'Dr. Mario Fatala Chabén', Buenos Aires, Argentina., Ramírez JD; Center for Research in Tropical Microbiology and Parasitology, Universidad de los Andes, Bogota, Colombia., Alberti A; Institute of Experimental Pathology, CONICET-Universidad Nacional de Salta, Salta, Argentina., Pavia P; Laboratory of Molecular Parasitology, Pontificia Universidad Javeriana, Bogota, Colombia., Flores-Chávez MD; National Center for Microbiology, Instituto de Salud Carlos III, Madrid, Spain., Muñoz-Calderón A; Institute of Tropical Medicine, Universidad Central de Venezuela, Caracas, Venezuela., Pérez-Morales D; Biomedical Research Institute, Universidad Nacional Autónoma de México, Mexico DF, Mexico., Santalla J; Laboratory of Parasitology and Molecular Biology, Instituto Nacional de Laboratorios en Salud, La Paz, Bolivia., Marcos da Matta Guedes P; Department of Microbiology and Parasitology, Universidade Federal do Rio Grande do Norte, Natal, Brazil., Peneau J; Hospital and University Laboratory-CH Andrée Rosemon, Cayenne, French Guiana., Marcet P; Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia., Padilla C; National Center for Public Health, Instituto Nacional de Salud, Lima, Peru., Cruz-Robles D; Laboratory of Genomics, Instituto Nacional de Cardiología 'Ignacio Chávez', Mexico DF, Mexico., Valencia E; Laboratory for Research in Infectious Diseases, Universidad Peruana Cayetano Heredia, Lima, Peru., Crisante GE; Department of Biology, Universidad de los Andes, Merida, Venezuela., Greif G; Molecular Biology Unit, Instituto Pasteur de Montevideo, Montevideo, Uruguay., Zulantay I; Basic Clinical Parasitology Laboratory, Universidad de Chile, Santiago, Chile., Costales JA; Research Center for Infectious Diseases, Pontificia Universidad Católica de Ecuador, Quito, Ecuador., Alvarez-Martínez M; Microbiology Department, Hospital Clinic and Barcelona Centre for International Health Research (CRESIB), Barcelona, Spain., Martínez NE; State Laboratory of Public Health, Acapulco, Mexico., Villarroel R; Biomedical Department, Instituto de Salud Pública, Santiago, Chile., Villarroel S; Laboratory of Molecular Biology, Universidad Mayor de San Simón, Cochabamba, Bolivia., Sánchez Z; Research Institute for Health Sciences, Universidad Nacional de Asunción, Asuncion, Paraguay., Bisio M; Laboratory of Molecular Biology of Chagas Disease (LaBMECh), Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI-CONICET), Buenos Aires, Argentina., Parrado R; Laboratory of Molecular Biology, Universidad Mayor de San Simón, Cochabamba, Bolivia., Maria da Cunha Galvão L; Department of Microbiology and Parasitology, Universidade Federal do Rio Grande do Norte, Natal, Brazil., Jácome da Câmara AC; Department of Microbiology and Parasitology, Universidade Federal do Rio Grande do Norte, Natal, Brazil., Espinoza B; Biomedical Research Institute, Universidad Nacional Autónoma de México, Mexico DF, Mexico., Alarcón de Noya B; Institute of Tropical Medicine, Universidad Central de Venezuela, Caracas, Venezuela., Puerta C; Laboratory of Molecular Parasitology, Pontificia Universidad Javeriana, Bogota, Colombia., Riarte A; National Institute of Parasitology 'Dr. Mario Fatala Chabén', Buenos Aires, Argentina., Diosque P; Institute of Experimental Pathology, CONICET-Universidad Nacional de Salta, Salta, Argentina., Sosa-Estani S; National Institute of Parasitology 'Dr. Mario Fatala Chabén', Buenos Aires, Argentina., Guhl F; Center for Research in Tropical Microbiology and Parasitology, Universidad de los Andes, Bogota, Colombia., Ribeiro I; Drugs for Neglected Diseases Initiative (DNDi), Geneva, Switzerland., Aznar C; Hospital and University Laboratory-CH Andrée Rosemon, Cayenne, French Guiana., Britto C; Laboratory of Molecular Biology of Endemic Diseases, Instituto Oswaldo Cruz/Fiocruz, Rio de Janeiro, Brazil., Yadón ZE; Communicable Diseases and Health Analysis Department, Pan American Health Organization/World Health Organization (PAHO/WHO), Rio de Janeiro, Brazil., Schijman AG; Laboratory of Molecular Biology of Chagas Disease (LaBMECh), Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI-CONICET), Buenos Aires, Argentina. Electronic address: schijman@dna.uba.ar.

Publikováno v: The Journal of molecular diagnostics : JMD [J Mol Diagn] 2015 Sep; Vol. 17 (5), pp. 605-15.