Mendelian randomisation and experimental medicine approaches to IL-6 as a drug target in PAH

Autor: Toshner, Mark, Church, Colin, Harbaum, Lars, Rhodes, Christopher, Villar Moreschi, Sofia S, Liley, James, Jones, Rowena, Arora, Amit, Batai, Ken, Desai, Ankit A, Coghlan, John G, Gibbs, J Simon R, Gor, Dee, Gräf, Stefan, Harlow, Louise, Hernandez-Sanchez, Jules, Howard, Luke S, Humbert, Marc, Karnes, Jason, Kiely, David G, Kittles, Rick, Knightbridge, Emily, Lam, Brian, Lutz, Katie A, Nichols, William C, Pauciulo, Michael W, Pepke-Zaba, Joanna, Suntharalingam, Jay, Soubrier, Florent, Trembath, Richard C, Schwantes-An, Tae-Hwi L, Wort, S John, Wilkins, Martin, Gaine, Sean, Morrell, Nicholas W, Corris, Paul A

Inflammation and dysregulated immunity are important in the development of pulmonary arterial hypertension. Compelling preclinical data supports the therapeutic blockade of interleukin-6 signalling.We conducted an open-label phase-II study of intrave

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Learning for Dose Allocation in Adaptive Clinical Trials with Safety Constraints

Autor: Villar Moreschi, Sofia

Phase I dose-finding trials are increasingly chal- lenging as the relationship between efficacy and toxicity of new compounds (or combination of them) becomes more complex. Despite this, most commonly used methods in practice fo- cus on identifying a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::97d5d018110f2416a12780e7de2bd0a0

Mendelian randomisation and experimental medicine approaches to interleukin-6 as a drug target in pulmonary arterial hypertension.

Autor: Toshner M; Dept of Medicine, University of Cambridge, Cambridge, UK mrt34@medschl.cam.ac.uk.; Royal Papworth Hospital, Cambridge, UK.; Authors contributed equally to this work., Church C; Golden Jubilee Hospital, Glasgow, UK.; Authors contributed equally to this work., Harbaum L; Heart Lung Research Institute, Imperial College, London, UK., Rhodes C; Heart Lung Research Institute, Imperial College, London, UK., Villar Moreschi SS; MRC Biostatistical Unit, University of Cambridge, Cambridge, UK., Liley J; Dept of Medicine, University of Cambridge, Cambridge, UK.; MRC Biostatistical Unit, University of Cambridge, Cambridge, UK., Jones R; Dept of Medicine, University of Cambridge, Cambridge, UK., Arora A; Dept of Epidemiology and Biostatistics, University of Arizona, Tucson, AZ, USA., Batai K; Dept of Urology, University of Arizona, Tucson, AZ, USA., Desai AA; Dept of Medicine, Indiana University, Indianapolis, IN, USA., Coghlan JG; Royal Free Hospital, London, UK., Gibbs JSR; Heart Lung Research Institute, Imperial College, London, UK., Gor D; Roche Products Limited, Welwyn Garden City, UK., Gräf S; Dept of Medicine, University of Cambridge, Cambridge, UK., Harlow L; Royal Papworth Hospital, Cambridge, UK., Hernandez-Sanchez J; Roche Products Limited, Welwyn Garden City, UK., Howard LS; Heart Lung Research Institute, Imperial College, London, UK., Humbert M; Université Paris-Sud, Le Kremlin-Bicêtre, Paris, France., Karnes J; Dept of Epidemiology and Biostatistics, University of Arizona, Tucson, AZ, USA., Kiely DG; Royal Hallamshire Hospital, Sheffield, UK., Kittles R; Dept of Epidemiology and Biostatistics, University of Arizona, Tucson, AZ, USA., Knightbridge E; Dept of Medicine, University of Cambridge, Cambridge, UK., Lam B; Institute of Metabolic Sciences, University of Cambridge, Cambridge, UK., Lutz KA; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Nichols WC; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Pauciulo MW; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA., Pepke-Zaba J; Royal Papworth Hospital, Cambridge, UK., Suntharalingam J; Royal United Hospital, Bath, UK., Soubrier F; Sorbonne Universités, INSERM, Paris, France., Trembath RC; Genetics and Molecular Medicine, King's College, London, UK., Schwantes-An TL; Dept of Medicine, Indiana University, Indianapolis, IN, USA., Wort SJ; Heart Lung Research Institute, Imperial College, London, UK., Wilkins MR; Heart Lung Research Institute, Imperial College, London, UK., Gaine S; Mater Misericordiae University Hospital, Dublin, Ireland., Morrell NW; Dept of Medicine, University of Cambridge, Cambridge, UK.; Authors contributed equally to this work., Corris PA; Dept of Medicine, Newcastle University, Newcastle, UK.; Authors contributed equally to this work.

Publikováno v: The European respiratory journal [Eur Respir J] 2022 Mar 10; Vol. 59 (3). Date of Electronic Publication: 2022 Mar 10 (Print Publication: 2022).