Kappa free light chains is a valid tool in the diagnostics of MS: A large multicenter study

Autor: Leurs, CE, Twaalfhoven, HAM, Lissenberg-Witte, BI, van Pesch, V, Dujmovic, I, Drulovic, J, Castellazzi, M, Bellini, T, Pugliatti, M, Kuhle, J, Villar, LM, Alvarez-Cermeño, JC, Alvarez-Lafuente, R, Hegen, H, Deisenhammer, F, Walchhofer, LM, Thouvenot, E, Comabella, M, Montalban, X, Vécsei, L, Rajda, C, Galimberti, D, Scarpini, E, Altintas, A, Rejdak, K, Frederiksen, JL, Pihl-Jensen, G, Jensen, PEH, Khalil, M, Voortman, MM, Fazekas, F, Saiz, Albert, La Puma, D, Vercammen, M, Vanopdenbosch, L, Uitdehaag, BMJ, Killestein, J, Bridel, C, Teunissen, Charlotte E, Universitat Autònoma de Barcelona

Publikováno v: Leurs, C E, Twaalfhoven, H A M, Lissenberg-Witte, B I, van Pesch, V, Dujmovic, I, Drulovic, J, Castellazzi, M, Bellini, T, Pugliatti, M, Kuhle, J, Villar, L M, Alvarez-Cermeño, J C, Alvarez-Lafuente, R, Hegen, H, Deisenhammer, F, Walchhofer, L M, Thouvenot, E, Comabella, M, Montalban, X, Vécsei, L, Rajda, C, Galimberti, D, Scarpini, E, Altintas, A, Rejdak, K, Frederiksen, J L, Pihl-Jensen, G, Jensen, P E H, Khalil, M, Voortman, M M, Fazekas, F, Saiz, A, la Puma, D, Vercammen, M, Vanopdenbosch, L, Uitdehaag, B M J, Killestein, J, Bridel, C & Teunissen, C 2020, ' Kappa free light chains is a valid tool in the diagnostics of MS: A large multicenter study ', Multiple Sclerosis Journal, vol. 26, no. 8, pp. 912-923 . https://doi.org/10.1177/1352458519845844
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona
Multiple Sclerosis (Houndmills, Basingstoke, England)
Multiple sclerosis, Vol. 26, no. 8, p. 912-923 (2020)
Multiple Sclerosis Journal
Leurs, C E, Twaalfhoven, H A M, Lissenberg-Witte, B I, van Pesch, V, Dujmovic, I, Drulovic, J, Castellazzi, M, Bellini, T, Pugliatti, M, Kuhle, J, Villar, L M, Alvarez-Cermeño, J C, Alvarez-Lafuente, R, Hegen, H, Deisenhammer, F, Walchhofer, L M, Thouvenot, E, Comabella, M, Montalban, X, Vécsei, L, Rajda, C, Galimberti, D, Scarpini, E, Altintas, A, Rejdak, K, Frederiksen, J L, Pihl-Jensen, G, Jensen, P E H, Khalil, M, Voortman, M M, Fazekas, F, Saiz, A, La Puma, D, Vercammen, M, Vanopdenbosch, L, Uitdehaag, B M J, Killestein, J, Bridel, C & Teunissen, C 2020, ' Kappa free light chains is a valid tool in the diagnostics of MS : A large multicenter study ', Multiple Sclerosis Journal, vol. 26, no. 8, pp. 912-923 . https://doi.org/10.1177/1352458519845844
Multiple Sclerosis Journal, 26(8), 912-923. SAGE Publications Ltd
Dipòsit Digital de la UB
Universidad de Barcelona
Multiple Sclerosis Journal, SAGE Publications, 2020, 26 (8), pp.912-923. ⟨10.1177/1352458519845844⟩

Objective: to validate kappa free light chain (KFLC) and lambda free light chain (LFLC) indices as a diagnostic biomarker in multiple sclerosis (MS). Methods: we performed a multicenter study including 745 patients from 18 centers (219 controls and 5

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce057f02105689f7c51817c72eb76440
https://research.vumc.nl/en/publications/d6fe1f10-dd53-44b5-b912-51125ff16ae3

Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome

Autor: Disanto, G1, Adiutori, R2, Dobson, R2, Martinelli, V3, Dalla Costa G3, Runia, T4, Evdoshenko, E5, Thouvenot, E6, Trojano, M7, Norgren, N8, Teunissen, C9, Kappos, L10, Giovannoni, G2, Kuhle, J, Bianchi, L, Topping, J, Bestwick, Jp, Meier, Uc, Lazareva, N, Iaffaldano, P, Direnzo, V, Khademi, M, Piehl, F, Comabella, M, Sombekke, M, Killestein, J, Hegen, H, Rauch, S, D'Alfonso, S, Alvarez-Cermeño, Jc, Kleinová, P, Horáková, D, Roesler, R, Lauda, F, Llufriu, S, Avsar, T, Uygunoglu, U, Altintas, A, Saip, S, Menge, T, Rajda, C, Bergamaschi, R, Moll, N, Khalil, M, Marignier, R, Dujmovic, I, Larsson, H, Malmestrom, C, Scarpini, E, Fenoglio, C, Wergeland, S, Laroni, A, Annibali, V, Romano, S, Martínez, Ad, Carra, A, Salvetti, M, Uccelli, A, Torkildsen, Ø, Myhr, Km, Galimberti, D, Rejdak, K, Lycke, J, Frederiksen, Jl, Drulovic, J, Confavreux, C, Brassat, D, Enzinger, C, Fuchs, S, Bosca, I, Pelletier, J, Picard, C, Colombo, E, Franciotta, D, Derfuss, T, Lindberg, Rl, Yaldizli, Ö, Vécsei, L, Kieseier, Bc, Hartung, Hp, Villoslada, P, Siva, A, Saiz, A, Tumani, H, Havrdová, E, Villar, Lm, Leone, M, Barizzone, N, Deisenhammer, F, Montalban, X, Tintoré, M, Olsson, T, Lehmann, S, Castelnovo, G, Lapin, S, Hintzen, R, Furlan, R, Comi, G, Ramagopalan, Sv.

Publikováno v: Disanto, G, Adiutori, R, Dobson, R, Martinelli, V, Costa, G D, Runia, T, Evdoshenko, E, Thouvenot, E, Trojano, M, Norgren, N, Teunissen, C, Kappos, L, Giovannoni, G & Kuhle, J 2016, ' Serum neurofilament light chain levels are increased in patients with a clinically isolated syndrome ', Journal of Neurology, Neurosurgery and Psychiatry, vol. 87, no. 2, pp. 126-129 . https://doi.org/10.1136/jnnp-2014-309690
Journal of Neurology, Neurosurgery and Psychiatry
Journal of Neurology, Neurosurgery and Psychiatry, BMJ Publishing Group, 2016, 87 (2), pp.126-9. ⟨10.1136/jnnp-2014-309690⟩
Journal of Neurology, Neurosurgery and Psychiatry, 87(2), 126-129. BMJ Publishing Group
Journal of Neurology Neurosurgery and Psychiatry, 87(2), 126-129. BMJ Publishing Group

International audience; BACKGROUND:Neurofilament light chain (NfL) represents a promising biomarker for axonal injury. We present the first exploratory study on serum NfL in patients with a clinically isolated syndrome (CIS) and healthy controls.METH

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04b59a87de239c8f54bc513dcd63945a
https://doi.org/10.1136/jnnp-2014-309690

Lipid Metabolism and Interleukin 28B Polymorphism in Hepatitis C

Autor: Porto Lc, Adnet Gcfs, Pollo-Flores P, Cásseres Dl, Padua L, Shiroma Me, Delvaux N, Villar Lm, Zampier L

Publikováno v: Journal of Infectious Diseases and Treatment. 2

Hepatitis C is a major public health problem and the main indication for liver transplantation in Brazil. Thus, the identification of patients and the provision of appropriate treatment are essential for the control and reduction of this infection. L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f31b03f7a0c3de624ea6752fca397535
https://doi.org/10.21767/2472-1093.100007

Immunoglobulin M oligoclonal bands: biomarker of targetable inflammation in primary progressive multiple sclerosis

Autor: Villar LM, Casanova B, Ouamara N, Comabella M, Jalili F, Leppert D, de Andrés C, Izquierdo G, Arroyo R, Avsar T, Lapin SV, Johnson T, Montalbán X, Fernández O, Álvarez-Lafuente R, Masterman D, García-Sánchez MI, Coret F, Siva A, Evdoshenko E, Álvarez-Cermeño JC, Bar-Or A

Publikováno v: ANNALS OF NEUROLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname

Objective: To identify a biomarker distinguishing patients who, despite a primary progressive multiple sclerosis (PPMS) clinical course, may nonetheless benefit from immune therapy. Methods: The presence or absence of both immunoglobulin (Ig) G and I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::8a117bccaf489eecf355a10634be11f4
https://pubmed.ncbi.nlm.nih.gov/24909126

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