Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Viljem, Pohorec"'
Autor:
Marko Šterk, Yaowen Zhang, Viljem Pohorec, Eva Paradiž Leitgeb, Jurij Dolenšek, Richard K P Benninger, Andraž Stožer, Vira Kravets, Marko Gosak
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 5, p e1012130 (2024)
Within the islets of Langerhans, beta cells orchestrate synchronized insulin secretion, a pivotal aspect of metabolic homeostasis. Despite the inherent heterogeneity and multimodal activity of individual cells, intercellular coupling acts as a homoge
Externí odkaz:
https://doaj.org/article/8347d06d07734c829efed481627ebe78
Autor:
Maša Skelin Klemen, Jurij Dolenšek, Lidija Križančić Bombek, Viljem Pohorec, Marko Gosak, Marjan Slak Rupnik, Andraž Stožer
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Beta cells couple stimulation by glucose with insulin secretion and impairments in this coupling play a central role in diabetes mellitus. Cyclic adenosine monophosphate (cAMP) amplifies stimulus-secretion coupling via protein kinase A and guanine nu
Externí odkaz:
https://doaj.org/article/6297194e5ee7452c9c230234b0a65125
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Although mice are a very instrumental model in islet beta cell research, possible phenotypic differences between strains and substrains are largely neglected in the scientific community. In this study, we show important phenotypic differences in beta
Externí odkaz:
https://doaj.org/article/2ac5319e3d0a447cb4b02069efc85606
Autor:
Urška Marolt, Eva Paradiž Leitgeb, Viljem Pohorec, Saška Lipovšek, Viktória Venglovecz, Eleonóra Gál, Attila Ébert, István Menyhárt, Stojan Potrč, Marko Gosak, Jurij Dolenšek, Andraž Stožer
Publikováno v:
PLoS ONE, Vol 17, Iss 6 (2022)
The physiology and pathophysiology of the exocrine pancreas are in close connection to changes in intra-cellular Ca2+ concentration. Most of our knowledge is based on in vitro experiments on acinar cells or acini enzymatically isolated from their sur
Externí odkaz:
https://doaj.org/article/67d403fb13634e8fbe745fc33fe3e7c3
Autor:
Sandra Postić, Srdjan Sarikas, Johannes Pfabe, Viljem Pohorec, Lidija Križančić Bombek, Nastja Sluga, Maša Skelin Klemen, Jurij Dolenšek, Dean Korošak, Andraž Stožer, Carmella Evans-Molina, James D. Johnson, Marjan Slak Rupnik
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 324:E42-E55
Physiological glucose or ryanodine stimulation of β cell collectives generates a large number of [Ca2+]c events, which can be rapidly assessed with our newly developed automatic image segmentation and [Ca2+]c event identification pipeline. The event
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78a069c6427a6d3af045dba9e6046bb7
https://doi.org/10.1152/ajpendo.00165.2022
https://doi.org/10.1152/ajpendo.00165.2022
Autor:
Andraž Stožer, Eva Paradiž Leitgeb, Viljem Pohorec, Jurij Dolenšek, Lidija Križančić Bombek, Marko Gosak, Maša Skelin Klemen
Publikováno v:
Cells, Vol 10, Iss 7, p 1658 (2021)
Pancreatic beta cells secrete insulin in response to stimulation with glucose and other nutrients, and impaired insulin secretion plays a central role in development of diabetes mellitus. Pharmacological management of diabetes includes various antidi
Externí odkaz:
https://doaj.org/article/b2b292f1083e46c382b373e59e25b985
Autor:
Eleonóra Gál, Jurij Dolenšek, Andraž Stožer, Viljem Pohorec, Attila Ébert, Viktória Venglovecz
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Introduction: The tissue slice technique offers several benefits compared to isolated cells and cell clusters that help us understand the (patho)physiology of several organs in situ. The most prominent features are preserved architecture and function
Externí odkaz:
https://doaj.org/article/182ba179ee6f418583479966f7636940
Autor:
Sandra, Postić, Srdjan, Sarikas, Johannes, Pfabe, Viljem, Pohorec, Lidija, Križančić Bombek, Nastja, Sluga, Maša, Skelin Klemen, Jurij, Dolenšek, Dean, Korošak, Andraž, Stožer, Carmella, Evans-Molina, James D, Johnson, Marjan, Slak Rupnik
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 324(1)
The release of peptide hormones is predominantly regulated by a transient increase in cytosolic Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a8c67f73f410b90f42f5e93328ef501b
https://pubmed.ncbi.nlm.nih.gov/36449570
https://pubmed.ncbi.nlm.nih.gov/36449570
Although mice are a very instrumental model in islet beta cell research, possible phenotypic differences between strains and substrains are largely neglected in the scientific community. In this study, we show important phenotypic differences in beta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5216560542376abe3e65e346ebcc409d
https://doi.org/10.1101/2022.01.14.476318
https://doi.org/10.1101/2022.01.14.476318
Autor:
Urška Marolt, Eva Paradiž Leitgeb, Viljem Pohorec, Saška Lipovšek, Viktória Venglovecz, Eleonóra Gál, Attila Ébert, István Menyhárt, Stojan Potrč, Marko Gosak, Jurij Dolenšek, Andraž Stožer
Publikováno v:
PloS one. 17(6)
The physiology and pathophysiology of the exocrine pancreas are in close connection to changes in intra-cellular Ca2+ concentration. Most of our knowledge is based on in vitro experiments on acinar cells or acini enzymatically isolated from their sur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0dae34a27a9667042e37c7fbae70800
https://pubmed.ncbi.nlm.nih.gov/35657915
https://pubmed.ncbi.nlm.nih.gov/35657915