A Novel Small Molecule GDNF Receptor RET Agonist, BT13, Promotes Neurite Growth from Sensory Neurons in Vitro and Attenuates Experimental Neuropathy in the Rat

Autor: Yulia A. Sidorova, Maxim M. Bespalov, Agnes W. Wong, Oleg Kambur, Viljami Jokinen, Tuomas O. Lilius, Ilida Suleymanova, Gunnar Karelson, Pekka V. Rauhala, Mati Karelson, Peregrine B. Osborne, Janet R. Keast, Eija A. Kalso, Mart Saarma

Publikováno v: Frontiers in Pharmacology, Vol 8 (2017)

Neuropathic pain caused by nerve damage is a common and severe class of chronic pain. Disease-modifying clinical therapies are needed as current treatments typically provide only symptomatic relief; show varying clinical efficacy; and most have signi

Externí odkaz: https://doaj.org/article/386952903bfa44e9aacfe166bb459eff

Morphine-3-glucuronide causes antinociceptive cross-tolerance to morphine and increases spinal substance P expression

Autor: Tuomas Lilius, Viljami Jokinen, Hanna Viisanen, Fredrik Harry Gustav Ahlström, Pekka Rauhala, Yulia Sidorova, Kim Juhani Blomqvist, Ilida Suleymanova, Eija Kalso

Publikováno v: Blomqvist, K J, Viisanen, H, Ahlstrom, F H G, Jokinen, V, Sidorova, Y A, Suleymanova, I, Rauhala, P V, Kalso, E A & Lilius, T O 2020, ' Morphine-3-glucuronide causes antinociceptive cross-tolerance to morphine and increases spinal substance P expression ', European Journal of Pharmacology, vol. 875, 173021 . https://doi.org/10.1016/j.ejphar.2020.173021
European Journal of Pharmacology

Morphine-3-glucuronide (M3G), the main metabolite of morphine, has been implicated in the development of tolerance and of opioid-induced hyperalgesia, both limiting the analgesic use of morphine. We evaluated the acute and chronic effects of M3G and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673c616608f79bac53572a6cbb3569fc
https://curis.ku.dk/ws/files/239562235/Morphine_3_glucuronide_causes_antinociceptive_cross_tolerance_to_morphine_and_increases_spinal_substance_P_expression.pdf

Pregabalin enhances the antinociceptive effect of oxycodone and morphine in thermal models of nociception in the rat without any pharmacokinetic interactions

Autor: Tuomas Lilius, Mikko Niemi, Viljami Jokinen, Pekka Rauhala, Eija Kalso, Jouko Laitila

Publikováno v: European Journal of Pain. 20:297-306

Background Oxycodone is increasingly being used in combination with pregabalin. Pregabalin use is prevalent in opioid-dependent individuals. A high number of deaths caused by the co-use of gabapentinoids and opioids occur. It is not known whether pre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ec096076e6fa20fb3a5fff8589906aa
https://doi.org/10.1002/ejp.728

Interactions of (2S,6S;2R,6R)-Hydroxynorketamine, a Secondary Metabolite of (R,S)-Ketamine, with Morphine

Autor: Tuomas Lilius, Eija Kalso, Mikko Niemi, Viljami Jokinen, Pekka Rauhala, Hanna Viisanen

Publikováno v: Basicclinical pharmacologytoxicology. 122(5)

Ketamine and its primary metabolite norketamine attenuate morphine tolerance by antagonising N-methyl-d-aspartate (NMDA) receptors. Ketamine is extensively metabolized to several other metabolites. The major secondary metabolite (2S,6S;2R,6R)-hydroxy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::138f2a704728a23f7e53e2fa88227104
https://pubmed.ncbi.nlm.nih.gov/29171155

Do Diuretics have Antinociceptive Actions: Studies of Spironolactone, Eplerenone, Furosemide and Chlorothiazide, Individually and with Oxycodone and Morphine

Autor: Jouko Laitila, Tuomas Lilius, Eija Kalso, Pekka Rauhala, Oleg Kambur, Viljami Jokinen, Mikko Niemi

Publikováno v: Basicclinical pharmacologytoxicology. 120(1)

Spironolactone, eplerenone, chlorothiazide and furosemide are diuretics that have been suggested to have antinociceptive properties, for example via mineralocorticoid receptor antagonism. In co-administration, diuretics might enhance the antinocicept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64aff5bc753f8445af444311d7e9c36d
https://pubmed.ncbi.nlm.nih.gov/27312359