Zobrazeno 1 - 10
of 626
pro vyhledávání: '"Vilhelm A. Bohr"'
Autor:
Jiangbo Song, Zhiquan Li, Lei Zhou, Xin Chen, Wei Qi Guinevere Sew, Héctor Herranz, Zilu Ye, Jesper Velgaard Olsen, Yuan Li, Marianne Nygaard, Kaare Christensen, Xiaoling Tong, Vilhelm A. Bohr, Lene Juel Rasmussen, Fangyin Dai
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract FOXO transcription factors modulate aging-related pathways and influence longevity in multiple species, but the transcriptional targets that mediate these effects remain largely unknown. Here, we identify an evolutionarily conserved FOXO tar
Externí odkaz:
https://doaj.org/article/6d8e7769443a4b1ca5a7abe0242df507
Autor:
Alejandro Marmolejo-Garza, Laurent Chatre, Deborah L. Croteau, Alejandro Herron-Bedoya, Minh Danh Anh Luu, Benoit Bernay, Julien Pontin, Vilhelm A. Bohr, Erik Boddeke, Amalia M. Dolga
Publikováno v:
Neurobiology of Disease, Vol 200, Iss , Pp 106645- (2024)
Summary: Nicotinamide riboside (NR), a precursor of nicotinamide adenine dinucleotide (NAD+), has robust cognitive benefits and alleviates neuroinflammation in Alzheimer's Disease (AD) mouse models without decreasing beta-amyloid plaque pathology. Su
Externí odkaz:
https://doaj.org/article/4ee99df2197a4223b78289600027be29
Autor:
Ines Sanchez-Roman, Beatriz Ferrando, Camilla Myrup Holst, Jonas Mengel-From, Signe Hoei Rasmussen, Mikael Thinggaard, Vilhelm A. Bohr, Kaare Christensen, Tinna Stevnsner
Publikováno v:
Biomolecules, Vol 14, Iss 8, p 909 (2024)
Mitochondrial dysfunction and genomic instability are key hallmarks of aging. The aim of this study was to evaluate whether maintenance of physical capacities at very old age is associated with key hallmarks of aging. To investigate this, we measured
Externí odkaz:
https://doaj.org/article/3ba9bd023012494abc164fa3afd28d14
Autor:
Helena B. Madsen, Louise I. Pease, Rebekah-Louise Scanlan, Mansour Akbari, Lene J. Rasmussen, Daryl P. Shanley, Vilhelm A. Bohr
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2023)
Ataxia with oculomotor apraxia type 1 (AOA1) is a progressive neurodegenerative disorder characterized by a gradual loss of coordination of hand movements, speech, and eye movements. AOA1 is caused by an inactivation mutation in the APTX gene. APTX r
Externí odkaz:
https://doaj.org/article/a6596f6c18f54f9cb2dd3ab9d8bb0b99
Autor:
Sharath Anugula, Zhiquan Li, Yuan Li, Alexander Hendriksen, Peter Bjarn Christensen, Lin Wang, Jonathan M. Monk, Niels de Wind, Vilhelm A. Bohr, Claus Desler, Robert K. Naviaux, Lene Juel Rasmussen
Publikováno v:
Heliyon, Vol 9, Iss 6, Pp e17392- (2023)
Replication stress, caused by Rev1 deficiency, is associated with mitochondrial dysfunction, and metabolic stress. However, the overall metabolic alterations and possible interventions to rescue the deficits due to Rev1 loss remain unclear. Here, we
Externí odkaz:
https://doaj.org/article/c97fbe219a0b4f4aba53cc5c825abbed
Autor:
Yujun Hou, Jae-Hyeon Park, Xiuli Dan, Xixia Chu, Beimeng Yang, Mansoor Hussain, Deborah L. Croteau, Vilhelm A. Bohr
Publikováno v:
Neurobiology of Disease, Vol 180, Iss , Pp 106092- (2023)
RecQ helicase family proteins play vital roles in maintaining genome stability, including DNA replication, recombination, and DNA repair. In human cells, there are five RecQ helicases: RECQL1, Bloom syndrome (BLM), Werner syndrome (WRN), RECQL4, and
Externí odkaz:
https://doaj.org/article/57f19587acf542f398ae999bc66a4aae
Autor:
Le Zong, Mayuri Tanaka-Yano, Bongsoo Park, Hagai Yanai, Ferda T. Turhan, Deborah L. Croteau, Jane Tian, Evandro F. Fang, Vilhelm A. Bohr, Isabel Beerman
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 7, Iss 1, Pp 1-9 (2021)
Abstract NAD+ supplementation has significant benefits in compromised settings, acting largely through improved mitochondrial function and DNA repair. Elevating NAD+ to physiological levels has been shown to improve the function of some adult stem ce
Externí odkaz:
https://doaj.org/article/ddf050c242524dbc83af057e4f93df30
Autor:
Xixia Chu, Yujun Hou, Qiong Meng, Deborah L. Croteau, Yong Wei, Supriyo De, Kevin G. Becker, Vilhelm A. Bohr
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2022)
Alzheimer’s disease (AD) is the most common neurodegenerative disease. Growing evidence suggests an important role for gut dysbiosis and gut microbiota-host interactions in aging and neurodegeneration. Our previous works have demonstrated that supp
Externí odkaz:
https://doaj.org/article/dbd0f437e9bb44e8889e1b83f90a8e14
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 9, Pp 1466-1474 (2020)
Aging: changes in genome infrastructure Biochemical pathways that alter the physical organization of the genome could play a prominent role in age-related cellular degeneration. Chromosomal DNA is wound around proteins known as histones; when such as
Externí odkaz:
https://doaj.org/article/61d64ff24d09458295a89b9ea9be05ca
Autor:
Jin Zheng, Mansour Akbari, Claire Schirmer, Marie-Line Reynaert, Anne Loyens, Bruno Lefebvre, Luc Buée, Deborah L. Croteau, Marie-Christine Galas, Vilhelm A. Bohr
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-23 (2020)
Abstract Insoluble intracellular aggregation of tau proteins into filaments and neurodegeneration are histopathological hallmarks of Alzheimer disease (AD) and other tauopathies. Recently, prefibrillar, soluble, oligomeric tau intermediates have emer
Externí odkaz:
https://doaj.org/article/4be2c0d56ef84b94945839b795ca71a7