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Dysregulated Expression of Glycolipids in Tumor Cells: From Negative Modulator of Anti-Tumor Immunity to Promising Targets for Developing Therapeutic Agents

Autor: Jose Luis Daniotti, Ricardo Dante Lardone, Aldo Alejandro Vilcaes

Publikováno v: Frontiers in Oncology, Vol 5 (2016)

Glycolipids are complex molecules consisting of a ceramide lipid moiety linked to a glycan chain of variable length and structure. Among these are found the gangliosides, which are sialylated glycolipids ubiquitously distributed on the outer layer of

Externí odkaz: https://doaj.org/article/6476de2fbb1d49d9b1120a321dd9d1c2

Glycosylation of Glycolipids in Cancer: Basis for Development of Novel Therapeutic Approaches

Autor: Jose Luis Daniotti, Aldo Alejandro Vilcaes, Vanina eTorres Demichelis, Fernando Miguel Ruggiero, Macarena eRodriguez-Walker

Publikováno v: Frontiers in Oncology, Vol 3 (2013)

Altered networks of gene regulation underlie many pathologies, including cancer. There are several proteins in cancer cells that are turned either on or off, which dramatically alters the metabolism and the overall activity of the cell, with the comp

Externí odkaz: https://doaj.org/article/98fd88ba85fe49fdb2a60afb43a83038

Targeted delivery of immunotoxin by antibody to ganglioside GD3: a novel drug delivery route for tumor cells.

Autor: Vanina Torres Demichelis, Aldo A Vilcaes, Ramiro Iglesias-Bartolomé, Fernando M Ruggiero, Jose L Daniotti

Publikováno v: PLoS ONE, Vol 8, Iss 1, p e55304 (2013)

Gangliosides are sialic acid-containing glycolipids expressed on plasma membranes from nearly all vertebrate cells. The expression of ganglioside GD3, which plays essential roles in normal brain development, decreases in adults but is up regulated in

Externí odkaz: https://doaj.org/article/5285bd31bd8b4c878bed93e49f5a2177

Ganglioside synthesis by plasma membrane-associated sialyltransferase in macrophages

Autor: Vanina Torres Demichelis, Eduardo Garbarino-Pico, Jose L. Daniotti, Aldo Alejandro Vilcaes

Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
International Journal of Molecular Sciences, Vol 21, Iss 3, p 1063 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 3

Gangliosides are constituents of the mammalian cell membranes and participate in the inflammatory response. However, little is known about the presence and enzymatic activity of ganglioside sialyltransferases at the cell surface of macrophages, one o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7035565025b4b426460179e5bd346384
https://www.mdpi.com/1422-0067/21/3/1063