Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Vilas Hareshwar Dahanukar"'
Autor:
Pramod S. Chaudhari, Rakeshwar Bandichhor, Kurella Sreenivasulu, Christopher J. Cobley, Vilas Hareshwar Dahanukar, Srinivas Achanta, Abhishek Sud, Fiona Llewellyn‐Beard
Publikováno v:
Chemistry, an Asian journal. 15(10)
An alternate formal synthesis of Sitagliptin phosphate is disclosed from 2,4,5-trifluorobenzadehyde in 8 linear steps with an overall yield of 31%. The chiral β-amino acid moiety present in sitaglitpin is installed via an asymmetric hydrogenation fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e850cb4c3854cf6193b94085c6d99b
https://pubmed.ncbi.nlm.nih.gov/32128989
https://pubmed.ncbi.nlm.nih.gov/32128989
Autor:
Aalla Sampath, Chittireddy Venkata Ramana Reddy, Dattatray S. Metil, Jinna Rajender Reddy, E. R. R. Chandrashekar, Vilas Hareshwar Dahanukar, Rakeshwar Bandichhor
Publikováno v:
ChemistrySelect. 3:2723-2729
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df535c7d73b020918475e362da5f3e9f
https://doi.org/10.1002/slct.201702552
https://doi.org/10.1002/slct.201702552
Autor:
Aaseef Mohammad, Peter Joseph Mccormack, Vilas Hareshwar Dahanukar, Sharad S. Pachore, Swapnil Panditrao Sonawane, Ch. Venkatramana Reddy, Dattatray S. Metil, Rakeshwar Bandichhor
Publikováno v:
Organic Process Research & Development. 22:27-39
Efforts toward a synthesis and process optimization of canagliflozin 1 are described. Canagliflozin synthesis was accomplished via purified open ring intermediate 12. The process was optimized by employing quality by design (QbD) methodologies, and a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f7a67661cba2f7c60fc7897a3ee0326
https://doi.org/10.1021/acs.oprd.7b00281
https://doi.org/10.1021/acs.oprd.7b00281
Autor:
Swapna Akula, Siddaiah Vidavulur, Swapnil Panditrao Sonawane, Mudumbai Usha Jyothi, Sharad S. Pachore, Unniar K. Syam Kumar, Vilas Hareshwar Dahanukar, Sasikala Vemuri, Lakki Reddy Prakash, Mohammad Aaseef
Publikováno v:
ChemistrySelect. 2:9157-9161
Multiple sources of anticipated process and degradation impurities of canagliflozin drug has been identified during its laboratory optimization and later in commercial scale manufacturing process. The structure of these impurities were confirmed by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e47505782a67ef049ea64087680115fd
https://doi.org/10.1002/slct.201701973
https://doi.org/10.1002/slct.201701973
Autor:
Vikas Gajare, Michael C. Lloyd, Martin E. Fox, Rashid Abdul Rehman Khan, Moses Babu Janagili, Veerabhadra Pratap Tadikonda, Bhaskar Kandagatla, Manpreet Singh, Rajesh Kumar Rapolu, Javed Iqbal, Malavika Banda, Sandip R. Khobare, Srinivasa Reddy Kallam, Rajender Datrika, Vilas Hareshwar Dahanukar, Siddaiah Vidavalur, Saikat Sen, Vishnuvardhan Reddy Eda, Srinivas Oruganti
Publikováno v:
Tetrahedron. 73:4285-4294
An efficient multi-gram synthesis of (1R,2S,5S)-methyl 6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylate, a key chiral bicyclic proline fragment employed in the construction of the potent anti-HCV drug boceprevir, has been presented. The synthetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35b02de5b7167c85211aa1c1fb39a397
https://doi.org/10.1016/j.tet.2017.05.080
https://doi.org/10.1016/j.tet.2017.05.080
Autor:
Ishu Agarwal, Amjad Basha Mohammad, Vilas Hareshwar Dahanukar, Pramod S. Chaudhari, Rakeshwar Bandichhor, Abhishek Sud
Publikováno v:
Tetrahedron Letters. 58:1891-1894
A novel reaction involving in situ redox conversion of glyoxylate esters to glycine is described. Simple starting materials and mild conditions for the synthesis of glycine derivatives probably indicate a pathway towards prebiotic chemistry. This pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb021835ac95181cb51ad7879db96f16
https://doi.org/10.1016/j.tetlet.2017.04.010
https://doi.org/10.1016/j.tetlet.2017.04.010
Autor:
Rajesh Kumar Rapolu, Javed Iqbal, Narasimha Rao Nevuluri, Saikat Sen, Vilas Hareshwar Dahanukar, Bhaskar Kandagatla, Srinivas Oruganti
Publikováno v:
Monatshefte für Chemie - Chemical Monthly. 148:1477-1482
A convergent synthesis of the anti-coagulant drug apixaban has been efficiently demonstrated on a multi-gram scale. The synthetic route is noteworthy for its brevity and fact that it completely avoids the use of morpholine, a toxic and flammable reag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb108f01b9350a3decb544fcccee3092
https://doi.org/10.1007/s00706-017-1920-1
https://doi.org/10.1007/s00706-017-1920-1
Autor:
Nichola L. Davies, Srinivas Reddy Poreddy, Srikanth Sarat Chandra Gorantla, Vilas Hareshwar Dahanukar, D. Naresh Kumar Reddy, Karen E. Holt-Tiffin, George Evans, Justine Ann Peterson, Colin Dewar, Matthew Bycroft, Neil Triggs, Upadhya Timmanna, Michael Siegfried Quirmbach, Anna Fryszkowska, Toni Fleming, Garrett Hoge
Publikováno v:
Organic Process Research & Development. 20:1520-1528
Dehydroepiandrosterone (DHEA, 2) is an important endogenous steroid hormone in mammals used in the treatment of a variety of dysfunctions in female and male health,1 as well as an intermediate in the synthesis of steroidal drugs, such as abiraterone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d4657f88c412058c784253d300e8e18
https://doi.org/10.1021/acs.oprd.6b00215
https://doi.org/10.1021/acs.oprd.6b00215
Autor:
Vidavalur Siddaiah, U. K. Syam Kumar, Sandip R. Khobare, Sharad S. Pachore, Narendra Bhalchandra Ambhaikar, Vilas Hareshwar Dahanukar, Sarvesh Kumar
Publikováno v:
Journal of Chemical Sciences. 130
A Biginelli reaction of $$\upbeta $$ -ketonitriles, aldehydes and urea in principle can yield 5-cyano substituted dihydropyrimidinones. Although potentially very useful, this substituted heterocycle is often difficult to synthesize via the three comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73d3e18fed143823d03006cf516ba817
https://doi.org/10.1007/s12039-018-1467-7
https://doi.org/10.1007/s12039-018-1467-7
Autor:
Christopher J. Cobley, Martin E. Fox, Vilas Hareshwar Dahanukar, Armando Carlone, Bhaskar Kandagatla, Ada Martinelli, Riccardo Carbone, Srinivas Oruganti, Luca Bernardi, Mariafrancesca Fochi
Publikováno v:
Chemistry – A European Journal. 21:19208-19222
In the context of a programme directed at the manufacture of telaprevir, eight possible approaches to its bicyclic α-amino acid core, based on organocatalytic enantioselective conjugate additions to cyclopent-1-enecarbaldehyde, were identified and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::614682b05dc56e1b68ac7beb3968b84b
https://doi.org/10.1002/chem.201503352
https://doi.org/10.1002/chem.201503352