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Akademický článek

Pyrazole-based and N,N-diethylcarbamate functionalized some novel aurone analogs: Design, synthesis, cytotoxic evaluation, docking and SAR studies, against AGS cancer cell line

Autor: Ekta Lathwal, Sanjeev Kumar, Pranab Kumar Sahoo, Sushmita Ghosh, Sutapa Mahata, Vilas D. Nasare, Ravikumar Kapavarapu, Suresh Kumar

Publikováno v: Heliyon, Vol 10, Iss 5, Pp e26843- (2024)

The present study involves the design, synthesis, and biological evaluation of a series of thirty-three, pyrazole-based and N,N-diethylcarbamate functionalized, novel aurone analogs, against AGS cancer cell line. These novel aurone analogs are obtain

Externí odkaz: https://doaj.org/article/98c54e36f88b49d8aaaf3fccfc8477a9

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Akademický článek

Novel 1,2,3-triazole-aurone hybrids as cathepsin B inhibitors: One-pot synthesis, anti-proliferative, and drug modeling studies

Autor: Bhavna Saroha, Gourav Kumar, Suresh Kumar, Meena Kumari, Manishita Rani, Neera Raghav, Pranab Kumar Sahoo, Sushmita Ghosh, Sutapa Mahata, Vilas D. Nasare

Publikováno v: European Journal of Medicinal Chemistry Reports, Vol 5, Iss , Pp 100056- (2022)

In the present study, we have designed a series of novel 1,2,3-triazole-aurone hybrids, which were synthesized by a one-pot click reaction between a terminal alkyne and an in-situ generated azide, and evaluated as potential cathepsin B inhibitors. Th

Externí odkaz: https://doaj.org/article/57e7e7f4dc694399828bc1e66d6b20cd

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Akademický článek

Synthesis, cytotoxic evaluation and structure activity relationship of pyrazole hybrid aurones on gastric cancer (AGS) cell lines

Autor: Ekta Lathwal, Sanjeev Kumar, Pranab Kumar Sahoo, Sushmita Ghosh, Sutapa Mahata, Vilas D. Nasare, Suresh Kumar

Publikováno v: Results in Chemistry, Vol 4, Iss , Pp 100590- (2022)

A series of pyrazole hybrid aurones have been synthesized and evaluated for their cytotoxic activity against AGS CRL-1739 cell line. The structures of these hybrid aurones were confirmed based on their IR, 1H NMR, 13C NMR, and HRMS data. The impact o

Externí odkaz: https://doaj.org/article/c8866692295249808d68f14e39234ea8

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Akademický článek

Ultrasound assisted a one pot multicomponent and greener synthesis of 1,2,3-triazole incorporated aurone hybrids: Cathepsin B inhibition, anti-cancer activity against AGS cell line, and in-silico docking evaluation

Autor: Bhavna Saroha, Gourav Kumar, Suresh Kumar, Meena Kumari, Manishita Rani, Neera Raghav, Pranab Kumar Sahoo, Sushmita Ghosh, Sutapa Mahata, Vilas D. Nasare

Publikováno v: Current Research in Green and Sustainable Chemistry, Vol 5, Iss , Pp 100295- (2022)

Cathepsin B represents a group of lysosomal-encapsulated cellular cysteine proteases, whose upregulation is the critical risk factor for cancer progression and in the regulation of degenerative processes like apoptosis. Therefore, cysteine cathepsins

Externí odkaz: https://doaj.org/article/3023cb4c38b645eeb629842a4e3bb768

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