Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Viktoriya Dubrovskaya"'
Autor:
Safia S Aljedani, Tyler J Liban, Karen Tran, Ganesh Phad, Suruchi Singh, Viktoriya Dubrovskaya, Pradeepa Pushparaj, Paola Martinez-Murillo, Justas Rodarte, Alex Mileant, Vidya Mangala Prasad, Rachel Kinzelman, Sijy O'Dell, John R Mascola, Kelly K Lee, Gunilla B Karlsson Hedestam, Richard T Wyatt, Marie Pancera
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009543 (2021)
Understanding the molecular mechanisms by which antibodies target and neutralize the HIV-1 envelope glycoprotein (Env) is critical in guiding immunogen design and vaccine development aimed at eliciting cross-reactive neutralizing antibodies (NAbs). H
Externí odkaz:
https://doaj.org/article/5d1e169cb38444308637152c824457f6
Autor:
Shailendra Kumar Sharma, Natalia de Val, Shridhar Bale, Javier Guenaga, Karen Tran, Yu Feng, Viktoriya Dubrovskaya, Andrew B. Ward, Richard T. Wyatt
Publikováno v:
Cell Reports, Vol 11, Iss 4, Pp 539-550 (2015)
Viral glycoproteins mediate entry by pH-activated or receptor-engaged activation and exist in metastable pre-fusogenic states that may be stabilized by directed rational design. As recently reported, the conformationally fixed HIV-1 envelope glycopro
Externí odkaz:
https://doaj.org/article/2acc78d7717d48479da8ce020bf5668a
Autor:
Viktoriya Dubrovskaya, Javier Guenaga, Natalia de Val, Richard Wilson, Yu Feng, Arlette Movsesyan, Gunilla B Karlsson Hedestam, Andrew B Ward, Richard T Wyatt
Publikováno v:
PLoS Pathogens, Vol 13, Iss 9, p e1006614 (2017)
Extensive shielding by N-glycans on the surface of the HIV envelope glycoproteins (Env) restricts B cell recognition of conserved neutralizing determinants. Elicitation of broadly neutralizing antibodies (bNAbs) in selected HIV-infected individuals r
Externí odkaz:
https://doaj.org/article/85dc9c1cd2ad47ad822263f052e99506
Autor:
Kelly K. Lee, Paola Martinez-Murillo, S. Aljedani, Pradeepa Pushparaj, Sijy O'Dell, Rachel Kinzelman, Tyler J. Liban, John R. Mascola, Viktoriya Dubrovskaya, Gunilla B. Karlsson Hedestam, Ganesh E. Phad, Richard T. Wyatt, Justas Rodarte, Marie Pancera, Alexander Mileant, Vidya Mangala Prasad, Karen Tran, Suruchi Singh
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 9, p e1009543 (2021)
PLoS Pathogens, Vol 17, Iss 9, p e1009543 (2021)
Understanding the molecular mechanisms by which antibodies target and neutralize the HIV-1 envelope glycoprotein (Env) is critical in guiding immunogen design and vaccine development aimed at eliciting cross-reactive neutralizing antibodies (NAbs). H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05f0ea264ec651dba30d7e2477929fd7
https://pubmed.ncbi.nlm.nih.gov/34559844
https://pubmed.ncbi.nlm.nih.gov/34559844
Autor:
Komal Bhullar, Sanjana Narang, Suruchi Singh, Richard T. Wyatt, Benjamin Murrell, Karen Tran, Sijy O'Dell, Gunilla B. Karlsson Hedestam, Lawrence Shapiro, John R. Mascola, Néstor Vázquez Bernat, Christopher Sundling, Gilman Dionne, Marcel Martin, Chiara Sorini, Pradeepa Pushparaj, Ganesh E. Phad, Martin Corcoran, Marie Pancera, Paola Martinez-Murillo, Viktoriya Dubrovskaya, Eduardo J. Villablanca, Monika Adori
Publikováno v:
The Journal of Experimental Medicine
HIV-1 is an exceptionally difficult vaccine target, and only certain types of antibodies are effective. Vaccination induces antibodies that bind the virus with different efficiencies. This study investigates this process and reveals how the immune sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6892e3046bcac5d89fe313332d46e15
https://doi.org/10.1084/jem.20191155
https://doi.org/10.1084/jem.20191155
Autor:
Salar N. Khan, Devin Sok, Karen Tran, Viktoriya Dubrovskaya, Arlette Movsesyan, Dennis R. Burton, Richard T. Wyatt
Publikováno v:
Journal of virology. 93(11)
Protection against acquiring human immunodeficiency virus (HIV) infection may not require a vaccine in the conventional sense, because broadly neutralizing antibodies (bNAbs) alone prevent HIV infection in relevant animal challenge models. Additional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::105c0ed72954aa698d2e9de942af639e
https://pubmed.ncbi.nlm.nih.gov/29976677
https://pubmed.ncbi.nlm.nih.gov/29976677
Autor:
Barbara Carrette, Natalia de Val, Javier Guenaga, Viktoriya Dubrovskaya, Richard T. Wyatt, Andrew B. Ward, Shailendra Kumar Sharma
Publikováno v:
Journal of Virology. 90:2806-2817
Due to high viral diversity, an effective HIV-1 vaccine will likely require Envs derived from multiple subtypes to generate broadly neutralizing antibodies (bNAbs). Soluble Env mimics, like the native flexibly linked (NFL) and SOSIP trimers, derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab26f632ab6a2a0f5448215568aae290
https://doi.org/10.1128/jvi.02652-15
https://doi.org/10.1128/jvi.02652-15
Autor:
Salar N, Khan, Devin, Sok, Karen, Tran, Arlette, Movsesyan, Viktoriya, Dubrovskaya, Dennis R, Burton, Richard T, Wyatt
Publikováno v:
Journal of Virology
Protection against acquiring human immunodeficiency virus (HIV) infection may not require a vaccine in the conventional sense, because broadly neutralizing antibodies (bNAbs) alone prevent HIV infection in relevant animal challenge models. Additional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c23e2ba39384f3d4967f55a5940ac42d
https://pubmed.ncbi.nlm.nih.gov/31092683
https://pubmed.ncbi.nlm.nih.gov/31092683
Autor:
Richard K. Wilson, Andrew B. Ward, Arlette Movsesyan, Javier Guenaga, Viktoriya Dubrovskaya, Natalia de Val, Richard T. Wyatt, Yu Feng, Gunilla B. Karlsson Hedestam
Publikováno v:
PLoS Pathogens, Vol 13, Iss 9, p e1006614 (2017)
PLoS Pathogens
PLoS Pathogens
Extensive shielding by N-glycans on the surface of the HIV envelope glycoproteins (Env) restricts B cell recognition of conserved neutralizing determinants. Elicitation of broadly neutralizing antibodies (bNAbs) in selected HIV-infected individuals r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa2debc98ba4179f92b84714474889b
http://europepmc.org/articles/PMC5640423?pdf=render
http://europepmc.org/articles/PMC5640423?pdf=render
Autor:
Gemma E. Seabright, Krisha McKee, Christopher A. Cottrell, Daniel P. Leaman, Néstor Vázquez Bernat, Robert T. Bailer, Richard Wilson, Marie Pancera, Mark K. Louder, Andrew B. Ward, Gabriel Ozorowski, Shridhar Bale, Tyler J. Liban, Javier Guenaga, Michael B. Zwick, Gunilla B. Karlsson Hedestam, Max Crispin, Nicole A. Doria-Rose, Yu Feng, Lifei Yang, Viktoriya Dubrovskaya, Sijy O'Dell, Hannah L. Turner, John R. Mascola, Jonathan L. Torres, Arlette Movsesyan, Richard T. Wyatt, Karen Tran
Publikováno v:
Immunity
Summary The elicitation of broadly neutralizing antibodies (bNAbs) against the HIV-1 envelope glycoprotein (Env) trimer remains a major vaccine challenge. Most cross-conserved protein determinants are occluded by self-N-glycan shielding, limiting B c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a442644353e6ebfe3e56aab6a9e651d
https://doi.org/10.1016/j.immuni.2019.10.008
https://doi.org/10.1016/j.immuni.2019.10.008