Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Viktorija Daugvilaite"'
Autor:
Astrid S. Jørgensen, Viktorija Daugvilaite, Katia De Filippo, Christian Berg, Masa Mavri, Tau Benned-Jensen, Goda Juzenaite, Gertrud Hjortø, Sara Rankin, Jon Våbenø, Mette M. Rosenkilde
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Jørgensen et al. investigate the effects of the CXCR4 targeting agents, AMD3100 (Plerixafor) and AMD11070, and show that AMD3100, unlike AMD11070, is biased with intrinsic β-arrestin recruitment agonism and full G protein antagonism. They finally p
Externí odkaz:
https://doaj.org/article/d920693ad8d842c78b29bd1b15141947
Autor:
Line Barington, Liv von Voss Christensen, Kristian Kåber Pedersen, Kristine Niss Arfelt, Martin Roumain, Kristian Høj Reveles Jensen, Viktoria Madeline Skovgaard Kjær, Viktorija Daugvilaite, John F. Kearney, Jan Pravsgaard Christensen, Gertrud Malene Hjortø, Giulio G. Muccioli, Peter Johannes Holst, Mette Marie Rosenkilde
Publikováno v:
Cells, Vol 11, Iss 3, p 494 (2022)
B1 cells constitute a specialized subset of B cells, best characterized in mice, which is abundant in body cavities, including the peritoneal cavity. Through natural and antigen-induced antibody production, B1 cells participate in the early defense a
Externí odkaz:
https://doaj.org/article/ecdf797f65d7414b8242f2c44e167d78
Autor:
Rik Janssens, Daiane Boff, Pieter Ruytinx, Anneleen Mortier, Vincent Vanheule, Olav Larsen, Viktorija Daugvilaite, Mette M. Rosenkilde, Sam Noppen, Sandra Liekens, Dominique Schols, Ingrid De Meester, Ghislain Opdenakker, Sofie Struyf, Mauro M. Teixeira, Flávio A. Amaral, Paul Proost
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
CXCL12 is a chemotactic cytokine that attracts many different cell types for homeostasis and during inflammation. Under stress conditions, macrophages and granulocytes produce factors such as peroxynitrite as a consequence of their oxidative response
Externí odkaz:
https://doaj.org/article/5859ad49e4db4950860440e81e6cc56b
Autor:
Gertrud Malene Hjortø, Olav Larsen, Anne Steen, Christian Berg, Viktorija Daugvilaite, Suzan Fares, Morten Hansen, Simi Ali, Mette M Rosenkilde
Publikováno v:
Frontiers in Immunology, Vol 7 (2016)
The CCR7 ligands CCL19 and CCL21 are increasingly recognized as functionally different (biased). Using mature human dendritic cells (DCs), we show that CCL19 is more potent than CCL21 in inducing 3D chemotaxis. Intriguingly, CCL21 induces prolonged a
Externí odkaz:
https://doaj.org/article/17e2402f4682476ba3ca39d86fdef0ae
Autor:
Viktoria M. S. Kjær, Viktorija Daugvilaite, Tomasz M. Stepniewski, Christian M. Madsen, Astrid S. Jørgensen, Kaustubh R. Bhuskute, Asuka Inoue, Trond Ulven, Tau Benned-Jensen, Siv A. Hjorth, Gertrud M. Hjortø, Ee Von Moo, Jana Selent, Mette M. Rosenkilde
Publikováno v:
Science Signaling. 16
The chemotactic G protein–coupled receptor GPR183 and its most potent endogenous oxysterol ligand 7α,25-dihydroxycholesterol (7α,25-OHC) are important for immune cell positioning in secondary lymphoid tissues. This receptor-ligand pair is associa
Autor:
Sara M. Rankin, Viktorija Daugvilaite, Katia De Filippo, Goda Juzenaite, Astrid Sissel Jørgensen, Mette M. Rosenkilde, Maša Mavri, Christian Berg, Tau Benned-Jensen, Gertrud Malene Hjortø, Jon Våbenø
Publikováno v:
Communications Biology
Jorgensen, A S, Daugvilaite, V, De Filippo, K, Berg, C, Mavri, M, Benned-Jensen, T, Juzenaite, G, Hjorto, G, Rankin, S, Vabeno, J & Rosenkilde, M M 2021, ' Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization ', Communications Biology, vol. 4, no. 1, 569 . https://doi.org/10.1038/s42003-021-02070-9
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications biology, vol. 4, no. 569, 2021.
Jorgensen, A S, Daugvilaite, V, De Filippo, K, Berg, C, Mavri, M, Benned-Jensen, T, Juzenaite, G, Hjorto, G, Rankin, S, Vabeno, J & Rosenkilde, M M 2021, ' Biased action of the CXCR4-targeting drug plerixafor is essential for its superior hematopoietic stem cell mobilization ', Communications Biology, vol. 4, no. 1, 569 . https://doi.org/10.1038/s42003-021-02070-9
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications biology, vol. 4, no. 569, 2021.
Following the FDA-approval of the hematopoietic stem cell (HSC) mobilizer plerixafor, orally available and potent CXCR4 antagonists were pursued. One such proposition was AMD11070, which was orally active and had superior antagonism in vitro; however
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc85e58203949fdd2febe45ee002aba4
http://hdl.handle.net/10044/1/88841
http://hdl.handle.net/10044/1/88841
Autor:
Mette M. Rosenkilde, Christian Berg, Hans W. Mages, Richard A. Kroczek, Julia Madela, Viktorija Daugvilaite, Agnieszka Bauer, Sebastian Voigt, Stephanie Gurka
Publikováno v:
Bauer, A, Madela, J, Berg, C, Daugvilaite, V, Gurka, S, Mages, H W, Kroczek, R A, Rosenkilde, M M & Voigt, S 2020, ' Rat cytomegalovirus-encoded γ-chemokine vXCL1 is a highly adapted, species-specific agonist for rat XCR1-positive dendritic cells ', Journal of Cell Science, vol. 133, no. 5, jcs236190. . https://doi.org/10.1242/jcs.236190
Dendritic cells (DCs) expressing the chemokine receptor XCR1 are specialized in antigen cross-presentation to control infections with intracellular pathogens. XCR1-positive (XCR1+) DCs are attracted by XCL1, a γ-chemokine secreted by activated CD8+
Autor:
Katja Spiess, Sofie O. Bagger, Lola J. Torz, Kristian H. R. Jensen, Anna L. Walser, Jone M. Kvam, Ann‐Sofie K. Møgelmose, Viktorija Daugvilaite, Riia K. Junnila, Gertrud M. Hjortø, Mette M. Rosenkilde
Publikováno v:
Annals of the New York Academy of Sciences. 1456
Autor:
Mette M. Rosenkilde, Christian Berg, Jon Våbenø, Viktorija Daugvilaite, Anne Steen, Astrid Sissel Jørgensen
Publikováno v:
ACS Chemical Biology. 13:881-886
CXC chemokine receptor 4 (CXCR4) is involved in multiple physiological and pathological processes, notably as a coreceptor for human immunodeficiency virus (HIV) cell entry. Its broad expression pattern and vital biological importance make CXCR4 a tr
Autor:
Mette M. Rosenkilde, Clara Castello Echeverria, Andreas W. Sailer, Michael Lückmann, Viktorija Daugvilaite, Tau Benned-Jensen, Christian M. Madsen, Thomas M. Frimurer
Publikováno v:
British Journal of Pharmacology. 174:2031-2042
Background and Purpose The GPCR Epstein–Barr virus-induced gene 2 (EBI2, also known as GPR183) is activated by oxysterols and plays a pivotal role in the regulation of B cell migration during immune responses. While the molecular basis of agonist b