Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Viktoria Zoufal"'
Autor:
Michael Wölfl-Duchek, Severin Mairinger, Irene Hernández-Lozano, Thomas Filip, Viktoria Zoufal, Mathilde Löbsch, Johann Stanek, Claudia Kuntner, Thomas Wanek, Martin Bauer, Jens Pahnke, Oliver Langer
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 12, p 6514 (2022)
Multidrug resistance-associated protein 1 (MRP1, encoded by the ABCC1 gene) may contribute to the clearance of amyloid-beta (Aβ) peptides from the brain into the blood and stimulation of MRP1 transport activity may be a therapeutic approach to enhan
Externí odkaz:
https://doaj.org/article/345b7ceb1d814b2b93ff0baa533e5ae7
Autor:
Mohammed Ali Selo, Anne-Sophie Delmas, Lisa Springer, Viktoria Zoufal, Johannes A. Sake, Caoimhe G. Clerkin, Hanno Huwer, Nicole Schneider-Daum, Claus-Michael Lehr, Sabrina Nickel, Oliver Langer, Carsten Ehrhardt
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)
Multidrug resistance-associated protein-1 (MRP1/ABCC1) is highly expressed in human lung tissues. Recent studies suggest that it significantly affects the pulmonary disposition of its substrates, both after pulmonary and systemic administration. To b
Externí odkaz:
https://doaj.org/article/dda9e160b03342e883773c34d2c21a53
Autor:
Thomas Wanek, Viktoria Zoufal, Mirjam Brackhan, Markus Krohn, Severin Mairinger, Thomas Filip, Michael Sauberer, Johann Stanek, Thomas Pekar, Jens Pahnke, Oliver Langer
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 21, p 8245 (2020)
Background: ABCB1 (P-glycoprotein) and ABCG2 (breast cancer resistance protein) are co-localized at the blood-brain barrier (BBB), where they restrict the brain distribution of many different drugs. Moreover, ABCB1 and possibly ABCG2 play a role in A
Externí odkaz:
https://doaj.org/article/c3219dbf765445898a7e5deb449ed676
Autor:
Markus Krohn, Johann Stanek, Mirjam Brackhan, Oliver Langer, Viktoria Zoufal, Michael Sauberer, Jens Pahnke, Martin Bauer, Severin Mairinger, Nicolas Tournier, Thomas Wanek, Thomas Filip
Publikováno v:
Journal of Nuclear Medicine. 61:1050-1057
P-glycoprotein (ABC subfamily B member 1, ABCB1) plays an important role at the blood–brain barrier (BBB) in promoting clearance of neurotoxic β-amyloid (Aβ) peptides from the brain into the blood. ABCB1 expression and activity were found to be d
Autor:
Alexander Traxl, Thomas Wanek, Thomas Filip, Martin Bauer, Johann Stanek, Gaia Novarino, Severin Mairinger, Michael Sauberer, Stefan Poschner, Oliver Langer, Walter Jäger, Viktoria Zoufal, Nicolas Tournier
Publikováno v:
Molecular Pharmaceutics. 16:1282-1293
P-Glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) are two efflux transporters at the blood-brain barrier (BBB), which effectively restrict brain distribution of diverse drugs, such as tyrosine kinase inhibitors. There is a crucial n
Autor:
Markus Krohn, Thomas Filip, Thomas Wanek, Oliver Langer, Jens Pahnke, Severin Mairinger, Viktoria Zoufal, Thomas Pekar, Johann Stanek, Martin Bauer, Michael Sauberer
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism
J Cereb Blood Flow Metab
J Cereb Blood Flow Metab
P-glycoprotein (P-gp, ABCB1) is an efflux transporter at the blood–brain barrier (BBB), which mediates clearance of beta-amyloid (Aβ) from brain into blood. We used ( R)-[11C]verapamil PET in combination with partial P-gp inhibition with tariquida
Autor:
Johann Stanek, Viktoria Zoufal, Alexander Traxl, Thomas Filip, Thomas Wanek, Markus Krohn, Jens Pahnke, Severin Mairinger, Claudia Kuntner, Oliver Langer, Michael Sauberer, John D. Schuetz
Publikováno v:
Molecular Imaging and Biology
Purpose Multidrug resistance-associated proteins (MRPs) mediate the hepatobiliary and renal excretion of many drugs and drug conjugates. The positron emission tomography (PET) tracer 6-bromo-7-[11C]methylpurine is rapidly converted in tissues by glut
Autor:
Claudia Kuntner, Michael Sauberer, Thomas Wanek, Johann Stanek, Thomas Filip, Severin Mairinger, Markus Müller, Jens Pahnke, Viktoria Zoufal, Alexander Traxl, Oliver Langer
Publikováno v:
European Journal of Pharmaceutical Sciences. 115:212-222
Ko143 is a reference inhibitor of the adenosine triphosphate-binding cassette (ABC) transporter breast cancer resistance protein (humans: ABCG2, rodents: Abcg2) for in vitro and in vivo use. Previous in vitro data indicate that Ko143 binds specifical
Autor:
Viktoria, Zoufal, Severin, Mairinger, Mirjam, Brackhan, Markus, Krohn, Thomas, Filip, Michael, Sauberer, Johann, Stanek, Thomas, Wanek, Nicolas, Tournier, Martin, Bauer, Jens, Pahnke, Oliver, Langer
Publikováno v:
J Nucl Med
P-glycoprotein (ABC subfamily B member 1, ABCB1) plays an important role at the blood–brain barrier (BBB) in promoting clearance of neurotoxic β-amyloid (Aβ) peptides from the brain into the blood. ABCB1 expression and activity were found to be d
Autor:
Markus, Krohn, Viktoria, Zoufal, Severin, Mairinger, Thomas, Wanek, Kristin, Paarmann, Thomas, Brüning, Ivan, Eiriz, Mirjam, Brackhan, Oliver, Langer, Jens, Pahnke
Publikováno v:
Molecular pharmacology. 96(2)
ATP-binding cassette (ABC) transporters such as ABCB1 (P-glycoprotein), ABCC1 (MRP1), and ABCG2 (BCRP) are well known for their role in rendering cancer cells resistant to chemotherapy. Additionally, recent research provided evidence that, along with