Linking the response of endocrine regulated genes to adverse effects on sex differentiation improves comprehension of aromatase inhibition in a Fish Sexual Development Test

Autor: Elke Muth-Köhne, Viktoria Schiller, Kathi Westphal-Settele, Matthias Teigeler, Sabine Konradi, Jasmin Brückner, Martina Fenske, Christoph Schäfers

Publikováno v: Aquatic Toxicology. 176:116-127

The Fish Sexual Development Test (FSDT) is a non-reproductive test to assess adverse effects of endocrine disrupting chemicals. With the present study it was intended to evaluate whether gene expression endpoints would serve as predictive markers of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82546c8edc77961f164fa1a878beb58e

Transcriptome alterations in zebrafish embryos after exposure to environmental estrogens and anti-androgens can reveal endocrine disruption

Autor: Viktoria Schiller, Martina Fenske, Christoph Schäfers, Rainer Fischer, Ralf Kriehuber, Arne Wichmann

Publikováno v: Reproductive Toxicology. 42:210-223

Exposure to environmental chemicals known as endocrine disruptors (EDs) is in many cases associated with an unpredictable hazard for wildlife and human health. The identification of endocrine disruptive properties of chemicals certain to enter the aq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5c54f587271f9694f83f69f93299312
https://doi.org/10.1016/j.reprotox.2013.09.003

Persistence of endocrine disruption in zebrafish (Danio rerio) after discontinued exposure to the androgen 17β-trenbolone

Autor: Lisa, Baumann, Susanne, Knörr, Susanne, Keiter, Tina, Nagel, Kristina, Rehberger, Sina, Volz, Sophia, Oberrauch, Viktoria, Schiller, Martina, Fenske, Henrik, Holbech, Helmut, Segner, Thomas, Braunbeck

Publikováno v: Environmental toxicology and chemistry. 33(11)

The aim of the present study was to investigate the effects of the androgenic endocrine disruptor 17β-trenbolone on the sexual development of zebrafish (Danio rerio) with special emphasis on the question of whether adverse outcomes of developmental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d9e73f934cea314ca027b3dcea2ca651
https://pubmed.ncbi.nlm.nih.gov/25070268

Reversibility of endocrine disruption in zebrafish (Danio rerio) after discontinued exposure to the estrogen 17α-ethinylestradiol

Autor: Martina Fenske, Viktoria Schiller, Lisa Baumann, Sina Volz, Helmut Segner, Susanne Knörr, Susanne Keiter, Kristina Rehberger, Henrik Holbech, Thomas Braunbeck

Publikováno v: Baumann, L, Knörr, S, Keiter, S, Rehberger, K, Volz, S, Schiller, V, Fenske, M, Holbech, H, Segner, H & Braunbeck, T 2014, ' Reversibility of endocrine disruption in zebrafish (Danio rerio) after discontinued exposure to the estrogen 17α-ethinylestradiol ', Toxicology and Applied Pharmacology, vol. 278, no. 3, pp. 230-237 . https://doi.org/10.1016/j.taap.2014.04.025

The aim of the present study was to investigate the persistence of the feminizing effects of discontinued 17alpha-ethinylestradiol (EE2) exposure on zebrafish (Danio rerio). An exposure scenario covering the sensitive phase of sexual differentiation,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c11f4520938ab38fb02e2f5e83d408
https://pubmed.ncbi.nlm.nih.gov/24832493