Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Viktor Szegedi"'
Autor:
Viktor Szegedi, Emőke Bakos, Szabina Furdan, Bálint H Kovács, Dániel Varga, Miklós Erdélyi, Pál Barzó, Attila Szücs, Gábor Tamás, Karri Lamsa
Publikováno v:
PLoS Biology, Vol 21, Iss 2, p e3002001 (2023)
Accumulating evidence indicates that there are substantial species differences in the properties of mammalian neurons, yet theories on circuit activity and information processing in the human brain are based heavily on results obtained from rodents a
Externí odkaz:
https://doaj.org/article/415f45079a1b4d1aaaadd7ea8150e0ea
Publikováno v:
Интегративная физиология, Vol 1, Iss 3 (2020)
Development of anxiolytics requires animal models; therefore anxious (AX) and nonanxious (nAX) mice have been selectively bred based upon their adult behaviour in reaction to handling. Since inadequate response to postnatal challenges may have lifelo
Externí odkaz:
https://doaj.org/article/d7b7e2ed3d154b4db2a0fb6cfcdaff1a
Autor:
Viktor Szegedi, Melinda Paizs, Judith Baka, Pál Barzó, Gábor Molnár, Gabor Tamas, Karri Lamsa
Publikováno v:
eLife, Vol 9 (2020)
Inhibitory autapses are self-innervating synaptic connections in GABAergic interneurons in the brain. Autapses in neocortical layers have not been systematically investigated, and their function in different mammalian species and specific interneuron
Externí odkaz:
https://doaj.org/article/de96b47ad57c43868ff08e012a268b30
Autor:
Viktor Szegedi, Melinda Paizs, Eszter Csakvari, Gabor Molnar, Pal Barzo, Gabor Tamas, Karri Lamsa
Publikováno v:
PLoS Biology, Vol 14, Iss 11, p e2000237 (2016)
In the human neocortex, single excitatory pyramidal cells can elicit very large glutamatergic EPSPs (VLEs) in inhibitory GABAergic interneurons capable of triggering their firing with short (3-5 ms) delay. Similar strong excitatory connections betwee
Externí odkaz:
https://doaj.org/article/45d342ad021d4bf1a92214eaa438ab2d
Publikováno v:
Neural Plasticity, Vol 2015 (2015)
Hippocampal oscillations recorded under urethane anesthesia are proposed to be modulated by anxiolytics. All classes of clinically effective anxiolytics were reported to decrease the frequency of urethane theta; however, recent findings raise concern
Externí odkaz:
https://doaj.org/article/6968a04188594e7190687b0717c1acb3
Autor:
Ágnes Kasza, Botond Penke, Zsuzsanna Frank, Zsolt Bozsó, Viktor Szegedi, Ákos Hunya, Klaudia Németh, Gábor Kozma, Lívia Fülöp
Publikováno v:
Molecules, Vol 22, Iss 11, p 2007 (2017)
During the past 15 years, several genetically altered mouse models of human Alzheimer’s disease (AD) have been developed. These costly models have greatly facilitated the evaluation of novel therapeutic approaches. Injecting synthetic β-amyloid (A
Externí odkaz:
https://doaj.org/article/ed5383a4bbad4d378d869149bb5f6a6e
Publikováno v:
Neural Plasticity, Vol 2014 (2014)
Neuronal hyperexcitability is a phenomenon associated with early Alzheimer’s disease. The underlying mechanism is considered to involve excessive activation of glutamate receptors; however, the exact molecular pathway remains to be determined. Extr
Externí odkaz:
https://doaj.org/article/c676b943e6e648d496c4f9b425bd259f
Autor:
Nikolett Lénárt, Viktor Szegedi, Gábor Juhász, Aniko Kasztner, János Horváth, Erika Bereczki, Melinda E Tóth, Botond Penke, Miklós Sántha
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e46007 (2012)
AimsApoB-100 is the major protein component of cholesterol- and triglyceride-rich LDL and VLDL lipoproteins in the serum. Previously, we generated and partially described transgenic mice overexpressing the human ApoB-100 protein. Here, we further cha
Externí odkaz:
https://doaj.org/article/50388ac2af4d4398862f55cad7d2d37b
Autor:
Lívia Fülöp, István M Mándity, Gábor Juhász, Viktor Szegedi, Anasztázia Hetényi, Edit Wéber, Zsolt Bozsó, Dóra Simon, Mária Benkő, Zoltán Király, Tamás A Martinek
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e39485 (2012)
Background and aimsUnnatural self-organizing biomimetic polymers (foldamers) emerged as promising materials for biomolecule recognition and inhibition. Our goal was to construct multivalent foldamer-dendrimer conjugates which wrap the synaptotoxic β
Externí odkaz:
https://doaj.org/article/c62c21806277426e93cdaa90103e7a4d
Autor:
Balázs Barkóczi, Gábor Juhász, Robert G. Averkin, Imre Vörös, Petra Vertes, Botond Penke, Viktor Szegedi
Publikováno v:
Neural Plasticity, Vol 2012 (2012)
AMPA and NMDA receptors convey fast synaptic transmission in the CNS. Their relative contribution to synaptic output and phosphorylation state regulate synaptic plasticity. The AMPA receptor subunit GluA1 is central in synaptic plasticity. Phosphoryl
Externí odkaz:
https://doaj.org/article/295891f551eb4fee842b15e48d121034