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pro vyhledávání: '"Viktor Pastukh"'
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Minimal piggyBac vectors are a modified single-plasmid version of the classical piggyBac delivery system that can be used for stable transgene integration. These vectors have a truncated terminal domain in the delivery cassette and thus, integrate si
Externí odkaz:
https://doaj.org/article/1454676823654ed1b7ddd57d74c45add
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
Minimal piggyBac vectors are a modified single-plasmid version of the classical piggyBac delivery system that can be used for stable transgene integration. These vectors have a truncated terminal domain in the delivery cassette and thus, integrate si
Publikováno v:
American Journal of Physiology-Cell Physiology. 299:C289-C297
Hypernatremia exerts multiple cellular effects, many of which could influence the outcome of an ischemic event. To further evaluate these effects of hypernatremia, isolated neonatal cardiomyocytes were chronically incubated with medium containing eit
Publikováno v:
Annals of the New York Academy of Sciences. 1177:140-150
Hypoxia, a fundamental biological stimulus, uses reactive oxygen species (ROS) as second messengers. Surprising molecular targets of hypoxia-generated ROS are the specific bases within hypoxic response elements (HREs) of the vascular endothelial grow
Autor:
Julio F. Turrens, Viktor Pastukh, David V. Schaffer, Stephen W. Schaffer, Glenn L. Wilson, Josh Leonard, Craig Ricci
Publikováno v:
American Journal of Physiology-Cell Physiology. 294:C413-C422
Recently, it has become apparent that mitochondrial DNA (mtDNA) damage can rapidly initiate apoptosis independent of mutations, although the mechanism involved remains unclear. To elucidate this mechanism, angiotensin II-mediated apoptosis was studie
Publikováno v:
Free Radical Biology and Medicine. 43:1616-1626
Reactive oxygen species associated with hypoxic signaling in pulmonary arterial endothelial cells (PAECs) oxidatively modify specific nucleotides in the hypoxic response element (HRE) of the VEGF gene (FASEB J.19:387-394; 2005). In this study, we det
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 85:455-464
Diabetes is characterized by chronic hyperglycemia as well as insulin deficiency or resistance. However, the majority of research has focused on the consequences of hyperglycemia in development of diabetic complications, whereas the effects of insuli
Autor:
Viktor Pastukh, Mark N. Gillespie, Mykhaylo V. Ruchko, Olena M. Gorodnya, Svitlana Danchuk, Sergiy Sukhanov, Lyudmila I. Rachek
Publikováno v:
The FASEB Journal. 29
Mitochondrial dysfunction underlies many processes in the development of atherosclerosis, including generation of reactive oxygen species, apoptosis, and inflammation. Oxidative mtDNA damage is a proximate cause of mitochondrial dysfunction and there
Publikováno v:
Amino Acids. 23:395-400
Occlusion of the left main coronary artery led to a time-dependent release of taurine from the heart. Upon reperfusion, there was a second phase of taurine release, which exceeded the amount of taurine that exited the heart during the 45 min ischemic
Publikováno v:
The FASEB Journal. 28