Zobrazeno 1 - 10 of 31 pro vyhledávání: '"Viktor G. Kartsev"'
1
Akademický článek
Combined Cytotoxic Effect of Inhibitors of Proteostasis on Human Colon Cancer Cells
Autor: Alina D. Nikotina, Snezhana A. Vladimirova, Nadezhda E. Kokoreva, Elena Y. Komarova, Nikolay D. Aksenov, Sergey Efremov, Elizaveta Leonova, Rostislav Pavlov, Viktor G. Kartsev, Zhichao Zhang, Boris A. Margulis, Irina V. Guzhova
Publikováno v: Pharmaceuticals, Vol 15, Iss 8, p 923 (2022)
Despite significant progress in the diagnosis and treatment of colorectal cancer, drug resistance continues to be a major limitation of therapy. In this regard, studies aimed at creating combination therapy are gaining popularity. One of the most pro
Externí odkaz: https://doaj.org/article/95091978f5174c428b61b1cc9fcb38c8
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2
Akademický článek
Synthesis and antimicrobial activity of new amino derivatives of pyrano[4’’,3’’:4’,5’]pyrido[3’,2’:4,5]thieno[3,2-d]pyrimidine
Autor: SAMVEL N. SIRAKANYAN, ATHINA GERONIKAKI, DOMENICO SPINELLI, ELMIRA K. HAKOBYAN, VIKTOR G. KARTSEV, ANTHI PETROU, ANUSH A. HOVAKIMYAN
Publikováno v: Anais da Academia Brasileira de Ciências, Iss 0 (2018)
ABSTRACT Annulated thienopyrimidine derivatives attracted big interest of the scientific community due to their broad spectrum of biological activities among which are the inhibition of phosphodiesterase, antiproliferative and antimicrobial activitie
Externí odkaz: https://doaj.org/article/e378532b994a4a4c9d73dbb6aeb2e0d7
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4
Prevention of High Glucose-Mediated EMT by Inhibition of Hsp70 Chaperone
Autor: Viktor G Kartsev, Sergey G. Polonik, Elena Y. Komarova, Boris A. Margulis, Elizaveta Leonova, Dmitry G. Alexeev, Alina D. Nikotina, Sergey M. Efremov, Snezhana A Vladimirova, Irina V. Guzhova, Rostislav V. Pavlov
Publikováno v: International Journal of Molecular Sciences; Volume 22; Issue 13; Pages: 6902
International Journal of Molecular Sciences, Vol 22, Iss 6902, p 6902 (2021)
International Journal of Molecular Sciences
Hyperglycemia may contribute to the progression of carcinomas by triggering epithelial-to-mesenchymal transition (EMT). Some proteostasis systems are involved in metastasis; in this paper, we sought to explore the mechanism of Hsp70 chaperone in EMT.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47980f1922b9b93d09ac680568b49d7
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5
Molecular docking, design, synthesis and biological evaluation of novel 2,3-aryl-thiazolidin-4-ones as potent NNRTIs
Autor: Viktor G. Kartsev, Phaedra Eleftheriou, Anthi Petrou, Giovanni Maga, R. Boga, B. Bartolo, Athina Geronikaki, G. Franco, E. Crespan
Publikováno v: SAR and QSAR in Environmental Research. 30:697-714
Nonnucleoside reverse transcriptase inhibitors (NNRTIs) remain the most promising anti-AIDS agents that target the HIV-1 reverse transcriptase enzyme (RT). However, the efficiency of approved NNRTI drugs has decreased by the appearance of drug-resist
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f52ee332919ae37839f5f752877f61
https://doi.org/10.1080/1062936x.2019.1653364
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6
Synthesis and antimicrobial activity of new derivatives of pyrano[4',3':4',5']pyrido[3',2':4,5]thieno[3,2-d]pyrimidine and new heterocyclic systems
Autor: Samvel N. Sirakanyan, Elmira K. Hakobyan, Athina Geronikaki, Anush A. Hovakimyan, Domenico Spinelli, Viktor G. Kartsev
Publikováno v: Synthetic Communications. 49:1262-1276
Taking into account previously obtained biological results on some polyheterocyclic compounds (containing different heteroatoms) and in particular on several 8-amino-5-isopropyl-2,2-dimethyl-10-(methylthio)-1,4-dihydro-2H-pyrano[4’’,3’’:4’,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16bc569d07002f0de1474b613f00b1ba
https://doi.org/10.1080/00397911.2019.1595659
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8
Chemical Modification of Plant Alkaloids. 8. Stereocontrolled T-Reactions of (1R,5S,12S)-Tetrahydrocytisine Derivatives
Autor: E. K. Kultyshkina, Konstantin A. Krasnov, Pavel V. Dorovatovskii, E. V. Dobrokhotova, Viktor G. Kartsev, Ya. V. Zubavichus, Victor N. Khrustalev, N. Yu. Chernikova
Publikováno v: Chemistry of Natural Compounds. 54:739-744
New heterocyclic quinolizidine systems were prepared from (1R,5S,12S)-tetrahydrocytisine. The synthetic scheme included arylation of tetrahydrocytisine by 2-fluoro-5-nitrobenzaldehyde and condensation of the resulting aldehyde with 1,3-dimethylbarbit
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::edaec071670656807c7f728d5327221f
https://doi.org/10.1007/s10600-018-2459-z
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9
Synthesis of phenanthro[1,2- d ]azepine derivatives containing a new heterocyclic system from the aporphine alkaloid glaucine
Autor: Anatolii S. Morkovnik, Alexander A. Zubenko, Kirill Yu. Suponitsky, Viktor G. Kartsev, Lyudmila N. Divaeva, Alexander I. Klimenko
Publikováno v: Mendeleev Communications. 28:320-322
Derivatives of phenanthro[1,2-d]azepine, a previously unknown heterocyclic system, can be easily obtained from aporphine alkaloids by successive pyridine–pyridine and pyridine–azepine recyclizations. The starting glaucine was used as an illustrat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e402829dd3b436c289e41883e1d877a0
https://doi.org/10.1016/j.mencom.2018.05.031
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10
Recyclization of glaucine as a new route to litebamine derivatives
Autor: Ludmila G. Kuz'mina, Alexander A. Zubenko, L. N. Divaeva, Gennadii S. Borodkin, Anatolii S. Morkovnik, Viktor G. Kartsev, Alexander I. Klimenko
Publikováno v: Mendeleev Communications. 28:58-60
Using glaucine as an example, a convenient access to naphtho[2,1-f]isoquinoline (litebamine) derivatives is proposed. The synthetic scheme involves a stepwise pyridine–pyridine recyclization of the intermediate N-acylsecoaporphine analogues.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2c9141fe69a7bbfa425ddd33e86f658a
https://doi.org/10.1016/j.mencom.2018.01.019
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