Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Viktor Achter"'
Autor:
Lech Nieroda, Lukas Maas, Scott Thiebes, Ulrich Lang, Ali Sunyaev, Viktor Achter, Martin Peifer
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-8 (2019)
Abstract Background The massive amounts of data from next generation sequencing (NGS) methods pose various challenges with respect to data security, storage and metadata management. While there is a broad range of data analysis pipelines, these chall
Externí odkaz:
https://doaj.org/article/bfcbdad7e1bd4ebeb800f8187261aac1
Autor:
Julie George, Vonn Walter, Martin Peifer, Ludmil B. Alexandrov, Danila Seidel, Frauke Leenders, Lukas Maas, Christian Müller, Ilona Dahmen, Tiffany M. Delhomme, Maude Ardin, Noemie Leblay, Graham Byrnes, Ruping Sun, Aurélien De Reynies, Anne McLeer-Florin, Graziella Bosco, Florian Malchers, Roopika Menon, Janine Altmüller, Christian Becker, Peter Nürnberg, Viktor Achter, Ulrich Lang, Peter M. Schneider, Magdalena Bogus, Matthew G. Soloway, Matthew D. Wilkerson, Yupeng Cun, James D. McKay, Denis Moro-Sibilot, Christian G. Brambilla, Sylvie Lantuejoul, Nicolas Lemaitre, Alex Soltermann, Walter Weder, Verena Tischler, Odd Terje Brustugun, Marius Lund-Iversen, Åslaug Helland, Steinar Solberg, Sascha Ansén, Gavin Wright, Benjamin Solomon, Luca Roz, Ugo Pastorino, Iver Petersen, Joachim H. Clement, Jörg Sänger, Jürgen Wolf, Martin Vingron, Thomas Zander, Sven Perner, William D. Travis, Stefan A. Haas, Magali Olivier, Matthieu Foll, Reinhard Büttner, David Neil Hayes, Elisabeth Brambilla, Lynnette Fernandez-Cuesta, Roman K. Thomas
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
The molecular nature of large-cell neuroendocrine lung carcinomas (LCNEC) has remained unclear. Here, the authors show LCNECs represent a distinct transcriptional subgroup among lung cancers and comprise two molecular subgroups, type I (TP53 and STK1
Externí odkaz:
https://doaj.org/article/0b984304ba014836a34f2b6d1a57b335
Autor:
Carmen D. Herling, Nima Abedpour, Jonathan Weiss, Anna Schmitt, Ron Daniel Jachimowicz, Olaf Merkel, Maria Cartolano, Sebastian Oberbeck, Petra Mayer, Valeska Berg, Daniel Thomalla, Nadine Kutsch, Marius Stiefelhagen, Paula Cramer, Clemens-Martin Wendtner, Thorsten Persigehl, Andreas Saleh, Janine Altmüller, Peter Nürnberg, Christian Pallasch, Viktor Achter, Ulrich Lang, Barbara Eichhorst, Roberta Castiglione, Stephan C. Schäfer, Reinhard Büttner, Karl-Anton Kreuzer, Hans Christian Reinhardt, Michael Hallek, Lukas P. Frenzel, Martin Peifer
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
BCL2-inhibitor venetoclax is used to treat relapsed/refractory chronic lymphocytic leukemia (CLL). Here, the authors show the clonal dynamics towards venetoclax resistance by performing whole-exome sequencing of 8 CLL patients undergoing venetoclax t
Externí odkaz:
https://doaj.org/article/91cad87502c5439c87643a607b72a378
Autor:
Amit Kawalia, Susanne Motameny, Stephan Wonczak, Holger Thiele, Lech Nieroda, Kamel Jabbari, Stefan Borowski, Vishal Sinha, Wilfried Gunia, Ulrich Lang, Viktor Achter, Peter Nürnberg
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0126321 (2015)
Next generation sequencing (NGS) has been a great success and is now a standard method of research in the life sciences. With this technology, dozens of whole genomes or hundreds of exomes can be sequenced in rather short time, producing huge amounts
Externí odkaz:
https://doaj.org/article/f9221666786444fa8c4de881906d5c4f
Autor:
Lech Nieroda, Birgid Schömig-Markiefka, Junya Fukuoka, Reinhard Büttner, Alexey Pryalukhin, Viktor Achter, Alexander Quaas, Andrey Bychkov, Yuri Tolkach, Wolfgang Hulla, Anant Madabhushi
Publikováno v:
Modern Pathology
Digital pathology provides a possibility for computational analysis of histological slides and automatization of routine pathological tasks. Histological slides are very heterogeneous concerning staining, sections' thickness, and artifacts arising du
Autor:
Martin Peifer, Viktor Achter, Nima Abedpour, Matthias Fischer, Sandra Ackermann, Maria Cartolano, Tsun-Po Yang
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports
Scientific Reports
The identification of the mutational processes operating in tumour cells has implications for cancer diagnosis and therapy. These processes leave mutational patterns on the cancer genomes, which are referred to as mutational signatures. Recently, 81
Autor:
Ali Sunyaev, Lech Nieroda, Lukas Maas, Martin Peifer, Ulrich Lang, Viktor Achter, Scott Thiebes
Publikováno v:
BMC Bioinformatics
BMC bioinformatics, 20 (1), Art. Nr.: 29
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-8 (2019)
BMC bioinformatics, 20 (1), Art. Nr.: 29
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-8 (2019)
Background: The massive amounts of data from next generation sequencing (NGS) methods pose various challenges with respect to data security, storage and metadata management. While there is a broad range of data analysis pipelines, these challenges re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c1190377a55ade5eaea980589167735
Autor:
Bram De Wilde, Ulrich Lang, Ruth Volland, Johannes M. Heuckmann, Viktor Achter, Maral Saadati, Danielle Thierry-Mieg, Monika Ortmann, Kai-Oliver Henrich, Zhiyu Peng, Wenzel Vogel, Roman K. Thomas, Justin L. Roncaioli, Angelika Eggert, Ivo Leuschner, Andrea Krämer, Jean Thierry-Mieg, Johannes H. Schulte, Thomas Höfer, Graziella Bosco, Yvonne Kahlert, Peter Nürnberg, Aruljothi Mariappan, Stefanie Heynck, Erika Mariotti, Moritz Gartlgruber, Roderick J. O’Sullivan, Carl Herrmann, Michal R. Schweiger, Christian Gloeckner, Reinhard Büttner, Martin Peifer, Simon C. Watkins, Janine Altmüller, Barbara Hero, Matthias G. Fischer, Frank Berthold, Frederik Sand, Rene Schmidt, Chunxuan Shao, Frederik Roels, Anne Engesser, Fakhera Ikram, Larissa Savelyeva, Falk Hertwig, Sandra Ackermann, Daniel Dreidax, Jessica Theissen, Chen Zhao, Sven Perner, Frank Westermann, Emma Bell, Alexander Schramm, Roopika Menon, Leming Shi
Publikováno v:
Nature. 526:700-704
Neuroblastoma is a malignant paediatric tumour of the sympathetic nervous system1. Roughly half of these tumours regress spontaneously or are cured by limited therapy. By contrast, high-risk neuroblastomas have an unfavourable clinical course despite
Publikováno v:
Nature protocols. 13(6)
This protocol describes how to use Sclust, a method for copy-number analysis and mutational clustering, to identify subclonal populations in tumor samples. The genomes of cancer cells constantly change during pathogenesis. This evolutionary process c
Autor:
Magali Olivier, Sven Perner, Peter Nürnberg, William D. Travis, Viktor Achter, Steinar Solberg, Stefan A. Haas, Elisabeth Brambilla, Ruping Sun, Lynnette Fernandez-Cuesta, Yupeng Cun, Ilona Dahmen, Luca Roz, Anne McLeer-Florin, Graham Byrnes, Denis Moro-Sibilot, Gavin M. Wright, Christian Becker, Åslaug Helland, Tiffany M. Delhomme, Peter M. Schneider, Julie George, Martin Vingron, Walter Weder, Roman K. Thomas, Ludmil B. Alexandrov, Jürgen Wolf, Sylvie Lantuejoul, David N. Hayes, Maude Ardin, James McKay, Christian Brambilla, Roopika Menon, Matthew G. Soloway, Alex Soltermann, Christian Müller, Noémie Leblay, Thomas Zander, Ugo Pastorino, Odd Terje Brustugun, Vonn Walter, Jörg Sänger, Ulrich Lang, Aurélien de Reyniès, Marius Lund-Iversen, Graziella Bosco, Reinhard Büttner, Benjamin Solomon, Sascha Ansén, Matthieu Foll, Verena Tischler, Iver Petersen, Lukas Maas, Janine Altmüller, Joachim H. Clement, Frauke Leenders, Matthew D. Wilkerson, Danila Seidel, Florian Malchers, Magdalena Bogus, Martin Peifer, Nicolas Lemaitre
Publikováno v:
Nature Communications
Nature communications, vol 9, iss 1
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Nature communications, vol 9, iss 1
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Pulmonary large-cell neuroendocrine carcinomas (LCNECs) have similarities with other lung cancers, but their precise relationship has remained unclear. Here we perform a comprehensive genomic (n = 60) and transcriptomic (n = 69) analysis of 75 LCNECs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3143f41fcfedb2e7fcc6e45c3af60387
https://hdl.handle.net/21.11116/0000-0003-7405-521.11116/0000-0003-7407-3
https://hdl.handle.net/21.11116/0000-0003-7405-521.11116/0000-0003-7407-3