Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Viktar Yermolenka"'
Autor:
Evan D. Kharasch, Jane Blood, Viktar Yermolenka, Michael J. Avram, Konrad Meissner, Amber Francis
Publikováno v:
Anesthesiology. 119:941-953
Background: The blood–brain barrier is richly populated by active influx and efflux transporters influencing brain drug concentrations. Morphine, a drug with delayed clinical onset, is a substrate for the efflux transporter P-glycoprotein in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02d88769d4c1f2fbe6caa1903fc34e53
https://doi.org/10.1097/aln.0b013e3182a05bd3
https://doi.org/10.1097/aln.0b013e3182a05bd3
Background: Interindividual variability and drug interaction studies suggest that blood–brain barrier drug transporters mediate human methadone brain biodistribution. In vitro and animal studies suggest that methadone is a substrate for the efflux
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca48743b1037e2c5851f77c2fa20b52
https://europepmc.org/articles/PMC4562501/
https://europepmc.org/articles/PMC4562501/
