Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Viktória Lázár"'
Publikováno v:
npj Antimicrobials and Resistance, Vol 2, Iss 1, Pp 1-8 (2024)
Abstract While the rise of antibiotic resistance poses a global health challenge, the development of new antibiotics has slowed down over the past decades. This turned the attention of researchers towards the rational design of drug combination thera
Externí odkaz:
https://doaj.org/article/6003eacc494d4268a9d3bfb834681c90
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract The incidence of beta-lactam resistance among clinical isolates is a major health concern. A key method to study the emergence of antibiotic resistance is adaptive laboratory evolution. However, in the case of the beta-lactam ampicillin, bac
Externí odkaz:
https://doaj.org/article/7124a2549acf4a2e948cb2ba39f5f16c
Autor:
Bálint Kintses, Pramod K. Jangir, Gergely Fekete, Mónika Számel, Orsolya Méhi, Réka Spohn, Lejla Daruka, Ana Martins, Ali Hosseinnia, Alla Gagarinova, Sunyoung Kim, Sadhna Phanse, Bálint Csörgő, Ádám Györkei, Eszter Ari, Viktória Lázár, István Nagy, Mohan Babu, Csaba Pál, Balázs Papp
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The genetics underlying bacterial susceptibility to antimicrobial peptides (AMPs) remain unclear. Here, using a genome-wide chemical-genetic approach, the authors map the diversity of resistance determinants across AMPs in Escherichia coli and provid
Externí odkaz:
https://doaj.org/article/e0586b491c9a457fa943b36f2a4c75e9
Autor:
Réka Spohn, Lejla Daruka, Viktória Lázár, Ana Martins, Fanni Vidovics, Gábor Grézal, Orsolya Méhi, Bálint Kintses, Mónika Számel, Pramod K. Jangir, Bálint Csörgő, Ádám Györkei, Zoltán Bódi, Anikó Faragó, László Bodai, Imre Földesi, Diána Kata, Gergely Maróti, Bernadett Pap, Roland Wirth, Balázs Papp, Csaba Pál
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Antimicrobial peptides (AMPs) are emerging as drug candidates, but the risk of pathogen resistance is not well understood. Here, the authors investigate AMP resistance evolution in E. coli, finding physicochemical features that make AMPs less prone t
Externí odkaz:
https://doaj.org/article/e014c0e34853487181f89fde9d5f3e38
Autor:
Anett Dunai, Réka Spohn, Zoltán Farkas, Viktória Lázár, Ádám Györkei, Gábor Apjok, Gábor Boross, Balázs Szappanos, Gábor Grézal, Anikó Faragó, László Bodai, Balázs Papp, Csaba Pál
Publikováno v:
eLife, Vol 8 (2019)
Antibiotic resistance typically induces a fitness cost that shapes the fate of antibiotic-resistant bacterial populations. However, the cost of resistance can be mitigated by compensatory mutations elsewhere in the genome, and therefore the loss of r
Externí odkaz:
https://doaj.org/article/f1f5ba129f96417ca7ca9aa9d5e4278a
Autor:
Balázs Szappanos, Jonathan Fritzemeier, Bálint Csörgő, Viktória Lázár, Xiaowen Lu, Gergely Fekete, Balázs Bálint, Róbert Herczeg, István Nagy, Richard A. Notebaart, Martin J. Lercher, Csaba Pál, Balázs Papp
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
A fundamental question in evolutionary biology is how complex innovations requiring multiple genetic changes arise. Here the authors provide lines of evidence that changing environments facilitate the adaptive evolution of complex metabolic innovatio
Externí odkaz:
https://doaj.org/article/e6a43caad914438b9b00d707a65292f0
Autor:
Zoltán Bódi, Zoltán Farkas, Dmitry Nevozhay, Dorottya Kalapis, Viktória Lázár, Bálint Csörgő, Ákos Nyerges, Béla Szamecz, Gergely Fekete, Balázs Papp, Hugo Araújo, José L Oliveira, Gabriela Moura, Manuel A S Santos, Tamás Székely, Gábor Balázsi, Csaba Pál
Publikováno v:
PLoS Biology, Vol 15, Iss 6, p e1002607 (2017)
[This corrects the article DOI: 10.1371/journal.pbio.2000644.].
Externí odkaz:
https://doaj.org/article/bae5ab0467af40af8e6103f70de1b9ab
Autor:
Zoltán Bódi, Zoltán Farkas, Dmitry Nevozhay, Dorottya Kalapis, Viktória Lázár, Bálint Csörgő, Ákos Nyerges, Béla Szamecz, Gergely Fekete, Balázs Papp, Hugo Araújo, José L Oliveira, Gabriela Moura, Manuel A S Santos, Tamás Székely, Gábor Balázsi, Csaba Pál
Publikováno v:
PLoS Biology, Vol 15, Iss 5, p e2000644 (2017)
Genetically identical cells frequently display substantial heterogeneity in gene expression, cellular morphology and physiology. It has been suggested that by rapidly generating a subpopulation with novel phenotypic traits, phenotypic heterogeneity (
Externí odkaz:
https://doaj.org/article/8aa0f60a3d4b4da2b53a6c14ac85d68f
Autor:
Béla Szamecz, Gábor Boross, Dorottya Kalapis, Károly Kovács, Gergely Fekete, Zoltán Farkas, Viktória Lázár, Mónika Hrtyan, Patrick Kemmeren, Marian J A Groot Koerkamp, Edit Rutkai, Frank C P Holstege, Balázs Papp, Csaba Pál
Publikováno v:
PLoS Biology, Vol 12, Iss 8, p e1001935 (2014)
Adaptive evolution is generally assumed to progress through the accumulation of beneficial mutations. However, as deleterious mutations are common in natural populations, they generate a strong selection pressure to mitigate their detrimental effects
Externí odkaz:
https://doaj.org/article/a624b184cbfa4a45a6e9843686b840b3
Autor:
Viktória Lázár, Gajinder Pal Singh, Réka Spohn, István Nagy, Balázs Horváth, Mónika Hrtyan, Róbert Busa‐Fekete, Balázs Bogos, Orsolya Méhi, Bálint Csörgő, György Pósfai, Gergely Fekete, Balázs Szappanos, Balázs Kégl, Balázs Papp, Csaba Pál
Publikováno v:
Molecular Systems Biology, Vol 9, Iss 1, Pp n/a-n/a (2013)
The evolution of resistance to a single antibiotic is frequently accompanied by increased resistance to multiple other antimicrobial agents. In sharp contrast, very little is known about the frequency and mechanisms underlying collateral sensitivity.
Externí odkaz:
https://doaj.org/article/64e0182223244a08af0bfba73cb10665