Optimization of a Nucleophilic Two-Step Radiosynthesis of 6-O-(2-[18F]fluoroethyl)-6-O-desmethyl-diprenorphine ([18F]FE-DPN) for PET Imaging of Brain Opioid Receptors

Autor: Enikő Németh, Barbara Gyuricza, Viktória Forgács, Paul Cumming, Gjermund Henriksen, János Marton, Beate Bauer, Pál Mikecz, Anikó Fekete

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 17, p 13152 (2023)

We have established a method for nucleophilic one-pot, two-step radiosynthesis of the popular opioid receptor radioligand 6-O-(2-[18F]fluoroethyl)-6-O-desmethyl-diprenorphine ([18F]FE-DPN) from the novel precursor 6-O-(2-tosyloxyethyl)-6-O-desmethyl-

Externí odkaz: https://doaj.org/article/c1fcf105ced7449f8eeb5624b84f7ae9

Methods for the Determination of Transition Metal Impurities in Cyclotron-Produced Radiometals

Autor: Viktória Forgács, Anikó Fekete, Barbara Gyuricza, Dániel Szücs, György Trencsényi, Dezső Szikra

Publikováno v: Pharmaceuticals, Vol 15, Iss 2, p 147 (2022)

Cyclotron-produced radiometals must be separated from the irradiated target and purified from other metal impurities, which could interfere with the radiolabeling process. We compared different chromatographic and colorimetric methods to determine th

Externí odkaz: https://doaj.org/article/26e2b31d06d24e9e845d363fdffdb581

Determination of Total Radiochemical Purity of [18F]FDG and [18F]FET by High-Performance Liquid Chromatography Avoiding TLC Method

Autor: István Jószai, Cintia A. Balogh, Csaba Hámori, Dorottya Molnár, Viktória Forgács, Béla Rubleczky, György Trencsényi

Publikováno v: Chromatographia. 85:469-479

The goal of this work was to present two high-performance liquid chromatography (HPLC) method that could be applied for the determination of the total radioactive purity of 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) and O-(2-[18F]fluoroethyl)-L-tyros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ac43a4dae90e2041db54cea57f4f9f66
https://doi.org/10.1007/s10337-022-04155-x

Production of scandium radionuclides for theranostic applications: towards standardization of quality requirements

Autor: Piotr Garnuszek, Cyrille Alliot, Sandrine Huclier-Markai, Viktória Forgács, Ferid Haddad, Dezső Szikra, Renata Mikolajczak

Publikováno v: EJNMMI Radiopharmacy and Chemistry, Vol 6, Iss 1, Pp 1-40 (2021)
EJNMMI Radiopharmacy and Chemistry
EJNMMI Radiopharmacy and Chemistry, 2021, 6 (1), pp.19. ⟨10.1186/s41181-021-00131-2⟩

International audience; AbstractIn the frame of “precision medicine”, the scandium radionuclides have recently received considerable interest, providing personalised adjustment of radiation characteristics to optimize the efficiency of medical ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4e2f0cab4108d9af534dd3d4ee13a18
https://doaj.org/article/d27102a1c0c84a798a957b47bdb98ecb

Radiosynthesis and Preclinical Investigation of 11 C‐Labelled 3‐(4,5‐Diphenyl‐1,3‐oxazol‐2‐yl)propanal Oxime ([ 11 C]SZV 1287)

Autor: Tamás Kálai, Barbara Gyuricza, Viktória Forgács, György Trencsényi, Ádám Horváth, Enikő Németh, Judit P. Szabó, Péter Mátyus, Zsuzsanna Helyes, Adrienn Kis, Pál Mikecz, Anikó Fekete, Dezső Szikra

Publikováno v: ChemMedChem. 15:2470-2476

The radiosynthesis, as well as the in vivo and ex vivo biodistribution of the 11 C radiolabelled 3-(4,5-diphenyl-1,3-oxazol-2-yl)propanal oxime (6, [11 C]SZV 1287) are reported. SZV 1287 is a novel semicarbazide-sensitive amine oxidase (SSAO) inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::877a3453de70170ee540a1aec181eec2
https://doi.org/10.1002/cmdc.202000389