Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Vikram Shettigar"'
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
For years, ejection fraction has been an essentially ubiquitous measurement for assessing the cardiovascular function of animal models in research labs. Despite technological advances, it remains the top choice among research labs for reporting heart
Externí odkaz:
https://doaj.org/article/0c244a14b56b4655a07d12e0863ec417
Autor:
Jill T Kuwabara, Akitoshi Hara, Sumit Bhutada, Greg S Gojanovich, Jasmine Chen, Kanani Hokutan, Vikram Shettigar, Anson Y Lee, Lydia P DeAngelo, Jack R Heckl, Julia R Jahansooz, Dillon K Tacdol, Mark T Ziolo, Suneel S Apte, Michelle D Tallquist
Publikováno v:
eLife, Vol 11 (2022)
Fibroblasts produce the majority of collagen in the heart and are thought to regulate extracellular matrix (ECM) turnover. Although fibrosis accompanies many cardiac pathologies and is generally deleterious, the role of fibroblasts in maintaining the
Externí odkaz:
https://doaj.org/article/59bd1881150d4f2a8b06cd161b15c44e
Autor:
Jennifer M. Peterson, David J. Wang, Vikram Shettigar, Steve R. Roof, Benjamin D. Canan, Nadine Bakkar, Jonathan Shintaku, Jin-Mo Gu, Sean C. Little, Nivedita M. Ratnam, Priya Londhe, Leina Lu, Christopher E. Gaw, Jennifer M. Petrosino, Sandya Liyanarachchi, Huating Wang, Paul M. L. Janssen, Jonathan P. Davis, Mark T. Ziolo, Sudarshana M. Sharma, Denis C. Guttridge
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The molecular mechanisms leading to heart failure in patients with Duchenne muscular dystrophy are unclear. Here the authors show that NF-κB is activated in the heart of dystrophin-deficient mice and that its ablation rescues cardiac function throug
Externí odkaz:
https://doaj.org/article/aa724b3e4c7b4ada9b67a708841b1195
Autor:
Vikram Shettigar, Bo Zhang, Sean C. Little, Hussam E. Salhi, Brian J. Hansen, Ning Li, Jianchao Zhang, Steve R. Roof, Hsiang-Ting Ho, Lucia Brunello, Jessica K. Lerch, Noah Weisleder, Vadim V. Fedorov, Federica Accornero, Jill A. Rafael-Fortney, Sandor Gyorke, Paul M. L. Janssen, Brandon J. Biesiadecki, Mark T. Ziolo, Jonathan P. Davis
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Heart contraction, which is decreased in disease, is determined by Ca2+binding to troponin C. Here, the authors combine a protein engineering approach with gene therapy to modulate heart contractility in mice with the use of rationally designed Tropo
Externí odkaz:
https://doaj.org/article/9828c585327046c3b5306a0cb5e0d215
Autor:
Bin Liu, Shane D. Walton, Hsiang‐Ting Ho, Andriy E. Belevych, Svetlana B. Tikunova, Ingrid Bonilla, Vikram Shettigar, Bjorn C. Knollmann, Silvia G. Priori, Pompeo Volpe, Przemysław B. Radwański, Jonathan P. Davis, Sándor Györke
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 10 (2018)
BackgroundCatecholaminergic polymorphic ventricular tachycardia (CPVT) is a familial arrhythmogenic syndrome characterized by sudden death. There are several genetic forms of CPVT associated with mutations in genes encoding the cardiac ryanodine rece
Externí odkaz:
https://doaj.org/article/17b2d1203c6b4fb18ec412e87dd32e52
Autor:
Vineeta Tanwar, Matthew W. Gorr, Markus Velten, Clayton M. Eichenseer, Victor P. Long, Ingrid M. Bonilla, Vikram Shettigar, Mark T. Ziolo, Jonathan P. Davis, Stephen H. Baine, Cynthia A. Carnes, Loren E. Wold
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 4 (2017)
BackgroundParticulate matter (PM; PM2.5 [PM with diameters of
Externí odkaz:
https://doaj.org/article/8834cc780b87467b95f629cf680a40a2
Autor:
Hussam E. Salhi, Vikram Shettigar, Lorien Salyer, Sarah Sturgill, Elizabeth A. Brundage, Joel Robinett, Zhaobin Xu, Eaman Abay, Jeovanna Lowe, Paul M.L. Janssen, Jill A. Rafael-Fortney, Noah Weisleder, Mark T. Ziolo, Brandon J. Biesiadecki
Publikováno v:
Journal of Molecular and Cellular Cardiology. 176:84-96
Autor:
Vikram Shettigar, Kelsey M. Pinckard, Lisa A. Baer, Nickolai P Seculov, Kendra L Madaris, Eaman Abay, Diego Hernández-Saavedra, Mark T. Ziolo, Carmem Peres Valgas da Silva, Mikayla R Mehling, Kristin I. Stanford
Publikováno v:
International Journal of Obesity (2005)
Background Obesity increases the risk of developing impaired glucose tolerance (IGT) and type 2 diabetes (T2D) after myocardial infarction (MI). Brown adipose tissue (BAT) is important to combat obesity and T2D, and increasing BAT mass by transplanta
Autor:
Akitoshi Hara, Jill T Kuwabara, Sumit Bhutada, Greg S Gojanovich, Jasmine Chen, Kanani Hokutan, Vikram Shettigar, Anson Y Lee, Lydia P DeAngelo, Jack R Heckl, Julia R Jahansooz, Dillon K Tacdol, Mark T Ziolo, Suneel S Apte, Michelle D Tallquist
Publikováno v:
eLife. 11
Fibroblasts produce the majority of collagen in the heart and are thought to regulate extracellular matrix (ECM) turnover. Although fibrosis accompanies many cardiac pathologies and is generally deleterious, the role of fibroblasts in maintaining the
Autor:
Akitoshi Hara, Jill T Kuwabara, Sumit Bhutada, Greg S Gojanovich, Jasmine Chen, Kanani Hokutan, Vikram Shettigar, Anson Y Lee, Lydia P DeAngelo, Jack R Heckl, Julia R Jahansooz, Dillon K Tacdol, Mark T Ziolo, Suneel S Apte, Michelle D Tallquist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2c3d276734df664d05775d2dbe5f0a2e
https://doi.org/10.7554/elife.69854.sa2
https://doi.org/10.7554/elife.69854.sa2