Microglial activation persists beyond clinical recovery following sport concussion in collegiate athletes

Autor: Kiel D. Neumann, Vikram Seshadri, Xavier D. Thompson, Donna K. Broshek, Jason Druzgal, James C. Massey, Benjamin Newman, Jose Reyes, Spenser R. Simpson, Katelyenn S. McCauley, James Patrie, James R. Stone, Bijoy K. Kundu, Jacob E. Resch

Publikováno v: Frontiers in Neurology, Vol 14 (2023)

IntroductionIn concussion, clinical and physiological recovery are increasingly recognized as diverging definitions. This study investigated whether central microglial activation persisted in participants with concussion after receiving an unrestrict

Externí odkaz: https://doaj.org/article/3ade0642b03946f4849fb2c66ed8a293

Phagocytosis in the retina promotes local insulin production in the eye

Autor: J. Iker Etchegaray, Shannon Kelley, Kristen Penberthy, Laura Karvelyte, Yosuke Nagasaka, Sofia Gasperino, Soumen Paul, Vikram Seshadri, Michael Raymond, Ana Royo Marco, Jonathan Pinney, Marta Stremska, Brady Barron, Christopher Lucas, Nishikant Wase, Yong Fan, Emil Unanue, Bijoy Kundu, Tal Burstyn-Cohen, Justin Perry, Jayakrishna Ambati, Kodi S. Ravichandran

Publikováno v: Etchegaray, J I, Kelley, S, Penberthy, K K, Karvelyte, L, Nagasaka, Y, Gasperino, S, Paul, S, Seshadri, V, Raymond, M H, Marco, A R, Pinney, J, Stremska, M E, Barron, B, Lucas, C D, Wase, N, Fan, Y, Unanue, E, Kundu, B, Burstyn-Cohen, T, Perry, J S A, Jayakrishna, A & Ravichandran, K S 2023, ' Phagocytosis in the retina promotes local insulin production in the eye ', Nature Metabolism . https://doi.org/10.1038/s42255-022-00728-0

The retina is highly metabolically active, relying on glucose uptake and aerobic glycolysis. Situated in close contact to photoreceptors, a key function of cells in the retinal pigment epithelium (RPE) is phagocytosis of damaged photoreceptor outer s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e015ab2ee76d21aacd3289ac8c786341
https://doi.org/10.1038/s42255-022-00728-0

S‐nitrosylation of cytoskeletal proteins

Autor: Saurav Pandey, Allison L Horenberg, Vikram Seshadri, William H. Guilford, Alisa M Houghton

Publikováno v: Cytoskeleton. 76:243-253

Nitric oxide has pronounced effects on cellular functions normally associated with the cytoskeleton, including cell motility, shape, contraction, and mitosis. Protein S-nitrosylation, the covalent addition of a NO group to a cysteine sulfur, is a sig

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a17d0051308fb46cfdf6e7eaf37ceb1
https://doi.org/10.1002/cm.21520

Flame chemistry of tetrahydropyran as a model heteroatomic biofuel

Autor: Tina Kasper, Nils Hansen, Nicole J. Labbe, Phillip R. Westmoreland, Vikram Seshadri, Patrick Oßwald

Publikováno v: Proceedings of the Combustion Institute. 34:259-267

The flame chemistry of tetrahydropyran (THP), a cyclic ether, has been examined using vacuum-ultraviolet (VUV)-photoionization molecular-beam mass spectrometry (PI-MBMS) and flame modeling, motivated by the need to understand and predict the combusti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800b31b7ddbacc323476e0fe57fae293
https://doi.org/10.1016/j.proci.2012.07.027

Concerted Reactions and Mechanism of Glucose Pyrolysis and Implications for Cellulose Kinetics

Autor: Phillip R. Westmoreland, Vikram Seshadri

Publikováno v: The Journal of Physical Chemistry A. 116:11997-12013

Concerted reactions are proposed to be keys to understanding thermal decomposition of glucose in the absence of ionic chemistry, including molecular catalysis by ROH molecules such as H(2)O, other glucose molecules, and most of the intermediates and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb55d58d16e706576e6b2b08879a5fc
https://doi.org/10.1021/jp3085099