Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Vikram Sabapathy"'
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2022)
Lupus glomerulonephritis (LN) is a complex autoimmune disease characterized by circulating autoantibodies, immune-complex deposition, immune dysregulation and defects in regulatory T cell (Tregs). Treatment options rely on general immunosuppressants
Externí odkaz:
https://doaj.org/article/178700c6f70e45ee9843b13b460bef18
Publikováno v:
Frontiers in Medicine, Vol 7 (2020)
Acute kidney injury (AKI) is a major clinical burden affecting 20 to 50% of hospitalized and intensive care patients. Irrespective of the initiating factors, the immune system plays a major role in amplifying the disease pathogenesis with certain imm
Externí odkaz:
https://doaj.org/article/0ef0f9aa56b04057afcb07e7803f879e
Autor:
Vikram Sabapathy, Marta E. Stremska, Saleh Mohammad, Rebecca L. Corey, Poonam R. Sharma, Rahul Sharma
Publikováno v:
Frontiers in Pharmacology, Vol 10 (2019)
Obesity-linked (type 2) diabetic nephropathy (T2DN) has become the largest contributor to morbidity and mortality in the modern world. Recent evidences suggest that inflammation may contribute to the pathogenesis of T2DN and T-regulatory cells (Treg)
Externí odkaz:
https://doaj.org/article/0bd7776d396c40cb8eba3b4839dcd48a
Publikováno v:
Stem Cells International, Vol 2015 (2015)
Stem cell based therapies hold great promise for the treatment of human diseases; however results from several recent clinical studies have not shown a level of efficacy required for their use as a first-line therapy, because more often in these stud
Externí odkaz:
https://doaj.org/article/9596714da7974ec7b3d2262485d745a5
Publikováno v:
Stem Cells International, Vol 2015 (2015)
The spinal cord injury leads to enervation of normal tissue homeostasis ultimately leading to paralysis. Until now there is no proper cure for the treatment of spinal cord injury. Recently, cell therapy in animal spinal cord injury models has shown s
Externí odkaz:
https://doaj.org/article/3f63a0ace4844976b5d606a7b0b7cdd8
Autor:
Vikram Sabapathy, Balasubramanian Sundaram, Sreelakshmi V M, Pratheesh Mankuzhy, Sanjay Kumar
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e93726 (2014)
Human mesenchymal stem cells (MSCs) are a promising candidate for cell-based transplantation and regenerative medicine therapies. Thus in the present study Wharton's Jelly Mesenchymal Stem Cells (WJ-MSCs) have been derived from extra embryonic umbili
Externí odkaz:
https://doaj.org/article/0fea61edcc364e728b6410fe56b71398
Publikováno v:
Stem Cells International, Vol 2012 (2012)
Mesenchymal stem cells (MSCs) are an alluring therapeutic resource because of their plasticity, immunoregulatory capacity and ease of availability. Human BM-derived MSCs have limited proliferative capability, consequently, it is challenging to use in
Externí odkaz:
https://doaj.org/article/1a1a639430aa4a27b1e971f8e7a5495d
Autor:
Abigail G. Wolpe, Melissa A. Luse, Scott R. Johnstone, Jianxiang Xue, Vikram Sabapathy, Brent Wakefield, Rahul Sharma, Kevin Barr, Frank Beier, Dale Laird, Stefanie Redemann, Linda Columbus, Silvia Penuela, Brant E. Isakson
Publikováno v:
Paediatrics Publications
Pannexin channel isoforms (Panx1-3) are thought to release nucleotides into the extracellular milieu and have been shown to effect vascular hemodynamics. For this reason, we examined their mRNA and protein expression in hypertensive humans and geneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35de790385b481a395b6d6aecddd2669
https://ir.lib.uwo.ca/paedpub/762
https://ir.lib.uwo.ca/paedpub/762
Autor:
Rajkumar Venkatadri, Vikram Sabapathy, Murat Dogan, Saleh Mohammad, Scott E. Harvey, Sean R. Simpson, Jason M. Grayson, Nan Yan, Fred W. Perrino, Rahul Sharma
Publikováno v:
European journal of immunology. 52(5)
The Three Prime Repair EXonuclease I (TREX1) is critical for degrading post-apoptosis DNA. Mice expressing catalytically inactive TREX1 (TREX1 D18N) develop lupus-like autoimmunity due to chronic sensing of undegraded TREX1 DNA substrates, production
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f060d87aded2057f431066a87d29777a
https://pubmed.ncbi.nlm.nih.gov/35112355
https://pubmed.ncbi.nlm.nih.gov/35112355
Autor:
Ananda Basu, Vikram Sabapathy, Rajia Arbab, Rahul Sharma, Murat Dogan, Rajkumar Venkatadri, Rita Basu, Jennie Z. Ma
Publikováno v:
Diabetes. 70
People with diabetes mellitus are more vulnerable to viral infections including influenza and the ongoing COVID-19 pandemic. Fatal pneumonia and cytokine storm is a contributor to the mortality. We hypothesized that aberrant glycemic control induces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7412f9c0a3f24bf1e1affa9622ceff50
https://doi.org/10.2337/db21-1140-p
https://doi.org/10.2337/db21-1140-p