Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Vikram S. Patel"'
Autor:
Timothy R. Baker, Biswanath De, Michael J. Janusz, Sandra A. Heitmeyer, Stanislaw Pikul, Neil Gregory Almstead, Michael George Natchus, Y.O. Taiwo, Vikram S. Patel, Sean X. Peng, Kimberly K. Brown, E.B. Hookfin, Lily C. Hsieh
Publikováno v:
Inflammation Research. 55:60-65
Objective and Design: Hydroxamic-and carboxylic- acid based matrix metalloproteinase inhibitors (MMPIs) were compared for their potency against various MMPs, pharmacodynamic properties and in vivo efficacy in a model of cartilage degeneration. Materi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a929852435ec2512304b9a6330b90405
https://doi.org/10.1007/s00011-005-0014-4
https://doi.org/10.1007/s00011-005-0014-4
Autor:
David J. Foltz, Roger G. Bookland, Fei Gu, Michael J. Janusz, Glen E. Mieling, Lily C. Hsieh, Todd M. Branch, Selane L. King, Matthew Pokross, Vikram S. Patel, Sean X. Peng, Staszek Pikul, Susan M. Garver, Matthew J. Laufersweiler, Biswanath De, Timothy R. Baker, Michael George Natchus, Neil Gregory Almstead
Publikováno v:
Journal of Medicinal Chemistry. 44:1060-1071
A series of carboxylic acids were prepared from a propargylglycine scaffold and tested for efficacy as matrix metalloproteinase (MMP) inhibitors. Detailed SAR for the series is reported for four enzymes within the MMP family. The inhibitors were typi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0bf39acf42ba63cb73f32d78dec0c97
https://doi.org/10.1021/jm000477l
https://doi.org/10.1021/jm000477l
Autor:
Susan M. Garver, Renee D Gauw, Debbie L Kuhlenbeck, Vikram S. Patel, Peter J. Stoffolano, Kenneth R. Wehmeyer, Timothy R. Baker
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 744:283-291
Semi-automated 96-well plate solid-phase extraction (SPE) was used for sample preparation of fluprostenol, a prostaglandin analog, in rat plasma prior to detection by gas chromatography-negative chemical ionization tandem mass spectrometry (GC-NCI-MS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3c211fb9cd0b57d426c72f4aff6939a
https://doi.org/10.1016/s0378-4347(00)00254-1
https://doi.org/10.1016/s0378-4347(00)00254-1
Autor:
Vikram S. Patel, Dan L. Wagner
Publikováno v:
International Journal of Pharmaceutics. 114:171-176
Steady-state human pharmacokinetics and bioavailability were compared for a sustained-release decongestant/ expectorant tablet and two coadministered immediate-release liquids that together contained the same active ingredients. In each leg of a rand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e227fe7fce9c3b39203c701957dace2e
https://doi.org/10.1016/0378-5173(94)00235-w
https://doi.org/10.1016/0378-5173(94)00235-w
Autor:
Kristin M. Phipps, Lisa Borges-Marcucci, KehDih Lai, Douglas C. Harnish, Matthew L. Crawley, Vikram S. Patel, Irene Feingold, Rayomand J. Unwalla, John F. Mehlmann, Wah-Tung Hum, Paige Erin Mahaney, Thomas Joseph Commons, Julius E Eta, Jay E. Wrobel, Weixin Xu, Daniel M. Green, Kim Callain Younghee, Mark J. Evans, Joseph T. Lundquist
Publikováno v:
Journal of medicinal chemistry. 53(4)
In an effort to develop orally active farnesoid X receptor (FXR) agonists, a series of tetrahydroazepinoindoles with appended solubilizing amine functionalities were synthesized. The crystal structure of the previously disclosed FXR agonist, 1 (FXR-4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00bfd83c46363610331843bd86e58272
https://pubmed.ncbi.nlm.nih.gov/20095622
https://pubmed.ncbi.nlm.nih.gov/20095622
Autor:
Fei Gu, David M. Bornes, E.B. Hookfin, Glen E. Mieling, Matthew Pokross, Timothy R. Baker, Michael J. Strojnowski, Sandra A. Heitmeyer, Susan M. Garver, Stanislaw Pikul, David J. Foltz, Lily C. Hsieh, Vikram S. Patel, Michael George Natchus, Michael J. Janusz, Biswanath De, Sean X. Peng, Martin E. Dowty, Charles R. Dietsch, Neil Gregory Almstead, Yetunde Olabisi Taiwo, Roger G. Bookland
Publikováno v:
Journal of medicinal chemistry. 43(26)
A series of hydroxamates was prepared from an aminoproline scaffold and tested for efficacy as matrix metalloproteinase (MMP) inhibitors. Detailed SAR for the series is reported for five enzymes within the MMP family, and a number of inhibitors, such
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf0f2a0b0432bdbaffa16d228b9204e8
https://pubmed.ncbi.nlm.nih.gov/11150165
https://pubmed.ncbi.nlm.nih.gov/11150165
Autor:
Vikram S. Patel, William G. Kramer
Publikováno v:
International Journal of Pharmaceutics. 30:221-224
Allopurinol is used clinically, with apparent success, as a rectal suppository for patients unable to take the medication by mouth. However, plasma levels of the drug or its active metabolite, oxipurinol, following administration of such dosage forms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f390a16419551add89cd6398ced8c56
https://doi.org/10.1016/0378-5173(86)90082-7
https://doi.org/10.1016/0378-5173(86)90082-7
Autor:
Vikram S. Patel, William G. Kramer
Publikováno v:
Journal of pharmaceutical sciences. 75(3)
Allopurinol exhibits good bioavailability (78-90%) after administration of oral dosage forms to humans and rabbits; however, it is not absorbed rectally from any of the dosage forms to any significant extent. Oral administration of allopurinol in a p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfc82b1ec7cbb0f80d66d060178d47d0
https://pubmed.ncbi.nlm.nih.gov/3701610
https://pubmed.ncbi.nlm.nih.gov/3701610
Autor:
Institute of Medicine, Board on Health Sciences Policy, Forum on Medical and Public Health Preparedness for Catastrophic Events, Forum on Drug Discovery, Development, and Translation, Anne B. Claiborne, Bruce M. Altevogt, Theresa Wizemann
Whether or not the United States has safe and effective medical countermeasures—such as vaccines, drugs, and diagnostic tools—available for use during a disaster can mean the difference between life and death for many Americans. The Food and Drug
