Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Vikram R Paralkar"'
Publikováno v:
STAR Protocols, Vol 4, Iss 3, Pp 102463- (2023)
Summary: FISH-Flow (fluorescence in situ hybridization-flow cytometry) involves hybridizing fluorescent oligos to RNA and quantifying fluorescence at a single-cell level using flow cytometry. Here, we present a FISH-Flow protocol to quantify nascent
Externí odkaz:
https://doaj.org/article/0625e8280db84ae2be336a4bdd381544
Autor:
Andrew H. Matthews, Alexander E. Perl, Selina M. Luger, Alison W. Loren, Saar I. Gill, David L. Porter, Daria V. Babushok, Ivan P. Maillard, Martin P. Carroll, Noelle V. Frey, Elizabeth O. Hexner, Mary Ellen Martin, Shannon R. McCurdy, Edward A. Stadtmauer, Vikram R. Paralkar, Ximena Jordan Bruno, Wei-Ting Hwang, David Margolis, Keith W. Pratz
Publikováno v:
Blood Advances. 6:3997-4005
CPX-351 and venetoclax and azacitidine (ven/aza) are both indicated as initial therapy for acute myeloid leukemia (AML) in older adults. In the absence of prospective randomized comparisons of these regimens, we used retrospective observational data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c851f4812c33e17a6d75e9e78bc482
https://doi.org/10.1182/bloodadvances.2022007265
https://doi.org/10.1182/bloodadvances.2022007265
Autor:
Taku Harada, Monika W. Perez, Jérémie Kalfon, Flora Dievenich Braes, Rashad Batley, Kenneth Eagle, Behnam Nabet, Becky Leifer, Jasmin Kruell, Vikram R. Paralkar, Kimberly Stegmaier, Angela N. Koehler, Stuart H. Orkin, Maxim Pimkin
Attenuating aberrant transcriptional circuits holds great promise for the treatment of numerous diseases, including cancer. However, development of transcriptional inhibitors is hampered by the lack of a generally accepted functional cellular readout
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::06df9ff7b14bf58386a0d5f67ab55268
https://doi.org/10.1101/2023.04.07.536032
https://doi.org/10.1101/2023.04.07.536032
Autor:
Maxim Pimkin, Stuart H. Orkin, Kimberly Stegmaier, Neekesh V. Dharia, Charles Y. Lin, Vikram R. Paralkar, Guillaume Kugener, Joshua M. Dempster, Jošt Vrabič Koren, Jazmin Ewers, Yaser Heshmati, Monika W. Perez, Jérémie Kalfon, Taku Harada, Kenneth Eagle
Relapse of acute myeloid leukemia (AML) after allogeneic bone marrow transplantation has been linked to immune evasion due to reduced expression of major histocompatibility complex class II (MHCII) genes through unknown mechanisms. In this work, we d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1693c3d64b55095362ff55f4f62ad653
https://doi.org/10.1158/2643-3230.c.6550953.v1
https://doi.org/10.1158/2643-3230.c.6550953.v1
Autor:
Maxim Pimkin, Stuart H. Orkin, Kimberly Stegmaier, Neekesh V. Dharia, Charles Y. Lin, Vikram R. Paralkar, Guillaume Kugener, Joshua M. Dempster, Jošt Vrabič Koren, Jazmin Ewers, Yaser Heshmati, Monika W. Perez, Jérémie Kalfon, Taku Harada, Kenneth Eagle
Supplementary Data from Transcriptional Plasticity Drives Leukemia Immune Escape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0aa2acc6dec2a0fcbac077aa8d703b98
https://doi.org/10.1158/2643-3230.22545486
https://doi.org/10.1158/2643-3230.22545486
Autor:
Maxim Pimkin, Stuart H. Orkin, Kimberly Stegmaier, Neekesh V. Dharia, Charles Y. Lin, Vikram R. Paralkar, Guillaume Kugener, Joshua M. Dempster, Jošt Vrabič Koren, Jazmin Ewers, Yaser Heshmati, Monika W. Perez, Jérémie Kalfon, Taku Harada, Kenneth Eagle
Supplementary Figure from Transcriptional Plasticity Drives Leukemia Immune Escape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53157264aa6ccb9251b8672b42de73ff
https://doi.org/10.1158/2643-3230.22545480.v1
https://doi.org/10.1158/2643-3230.22545480.v1
Autor:
Maxim Pimkin, Stuart H. Orkin, Kimberly Stegmaier, Neekesh V. Dharia, Charles Y. Lin, Vikram R. Paralkar, Guillaume Kugener, Joshua M. Dempster, Jošt Vrabič Koren, Jazmin Ewers, Yaser Heshmati, Monika W. Perez, Jérémie Kalfon, Taku Harada, Kenneth Eagle
Supplementary Table from Transcriptional Plasticity Drives Leukemia Immune Escape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61aedd63442cee36d0ab33a878c14119
https://doi.org/10.1158/2643-3230.22545477
https://doi.org/10.1158/2643-3230.22545477
Autor:
Andrew Matthews, Alexander E. Perl, Selina M. Luger, Saar Gill, Catherine Lai, David L. Porter, Sarah Skuli, Ximena Jordan Bruno, Craig W. Freyer, Alison Carulli, Martin P. Carroll, Daria V. Babushok, Noelle V. Frey, Elizabeth O. Hexner, Mary Ellen Martin, Shannon R. McCurdy, Edward A. Stadtmauer, Alison W. Loren, Vikram R Paralkar, Ivan Maillard, Keith W. Pratz
Publikováno v:
Blood. 140:1022-1024
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ebcf2d145574a9bd0825d8bf0bf00c9
https://doi.org/10.1182/blood-2022-168036
https://doi.org/10.1182/blood-2022-168036
Autor:
Kenneth Eagle, Taku Harada, Jérémie Kalfon, Monika W. Perez, Yaser Heshmati, Jazmin Ewers, Jošt Vrabič Koren, Joshua M. Dempster, Guillaume Kugener, Vikram R. Paralkar, Charles Y. Lin, Neekesh V. Dharia, Kimberly Stegmaier, Stuart H. Orkin, Maxim Pimkin
Publikováno v:
Blood Cancer Discovery. 3:394-409
Relapse of acute myeloid leukemia (AML) after allogeneic bone marrow transplantation has been linked to immune evasion due to reduced expression of major histocompatibility complex class II (MHCII) genes through unknown mechanisms. In this work, we d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a716c1d7f784285cb5708c8867f78bb5
https://doi.org/10.1158/2643-3230.bcd-21-0207
https://doi.org/10.1158/2643-3230.bcd-21-0207
Autor:
Taku Harada, Yaser Heshmati, Jérémie Kalfon, Monika W. Perez, Juliana Xavier Ferrucio, Jazmin Ewers, Benjamin Hubbell Engler, Andrew Kossenkov, Jana M. Ellegast, Joanna S. Yi, Allyson Bowker, Qian Zhu, Kenneth Eagle, Tianxin Liu, Yan Kai, Joshua M. Dempster, Guillaume Kugener, Jayamanna Wickramasinghe, Zachary T. Herbert, Charles H. Li, Jošt Vrabič Koren, David M. Weinstock, Vikram R. Paralkar, Behnam Nabet, Charles Y. Lin, Neekesh V. Dharia, Kimberly Stegmaier, Stuart H. Orkin, Maxim Pimkin
Publikováno v:
Genes & Development. 36:368-389
Acute myeloid leukemia with KMT2A (MLL) rearrangements is characterized by specific patterns of gene expression and enhancer architecture, implying unique core transcriptional regulatory circuitry. Here, we identified the transcription factors MEF2D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41b4d7a78af1a17e0bab960f57503beb
https://doi.org/10.1101/gad.349284.121
https://doi.org/10.1101/gad.349284.121