Zobrazeno 1 - 10
of 142
pro vyhledávání: '"Vikram Prasad"'
Autor:
Davy Vanhoutte, Tobias G. Schips, Rachel A. Minerath, Jiuzhou Huo, Naga Swathi Sree Kavuri, Vikram Prasad, Suh-Chin Lin, Michael J. Bround, Michelle A. Sargent, Christopher M. Adams, Jeffery D. Molkentin
Publikováno v:
Cell Reports, Vol 43, Iss 5, Pp 114149- (2024)
Summary: Loss of muscle mass is a feature of chronic illness and aging. Here, we report that skeletal muscle-specific thrombospondin-1 transgenic mice (Thbs1 Tg) have profound muscle atrophy with age-dependent decreases in exercise capacity and prema
Externí odkaz:
https://doaj.org/article/cbb8ebd5e51b4718a055bc0a6afa780b
Autor:
Jiuzhou Huo, Vikram Prasad, Kelly M. Grimes, Davy Vanhoutte, N. Scott Blair, Suh-Chin Lin, Michael J. Bround, Donald M. Bers, Jeffery D. Molkentin
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113465- (2023)
Summary: Mitochondria use the electron transport chain to generate high-energy phosphate from oxidative phosphorylation, a process also regulated by the mitochondrial Ca2+ uniporter (MCU) and Ca2+ levels. Here, we show that MCUb, an inhibitor of MCU-
Externí odkaz:
https://doaj.org/article/b65c0ce78b7040798c4078208b4eb116
Autor:
Justin G. Boyer, Jiuzhou Huo, Sarah Han, Julian R. Havens, Vikram Prasad, Brian L. Lin, David A. Kass, Taejeong Song, Sakthivel Sadayappan, Ramzi J. Khairallah, Christopher W. Ward, Jeffery D. Molkentin
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Boyer et al. created genetic mouse models of muscular dystrophy in which satellite cells were selectively depleted. The depletion of satellite cells at select times was protective. Myofibers no longer had plasma membrane instability leading to tissue
Externí odkaz:
https://doaj.org/article/05d4e5eb19ab42dd9227ed224828f09d
Autor:
Kelly M. Grimes, Vikram Prasad, Jiuzhou Huo, Yasuhide Kuwabara, Davy Vanhoutte, Tanya A. Baldwin, Stephanie L. K. Bowers, Anne Katrine Z. Johansen, Michelle A. Sargent, Suh-Chin J. Lin, Jeffery D. Molkentin
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction: The ribosomal protein L3-like (RPL3L) is a heart and skeletal muscle-specific ribosomal protein and paralogue of the more ubiquitously expressed RPL3 protein. Mutations in the human RPL3L gene are linked to childhood cardiomyopathy and
Externí odkaz:
https://doaj.org/article/e9e91a84e9de42468035dd74dbc281e1
Autor:
Stephanie L. K. Bowers, Qinghang Meng, Yasuhide Kuwabara, Jiuzhou Huo, Rachel Minerath, Allen J. York, Michelle A. Sargent, Vikram Prasad, Anthony J. Saviola, David Ceja Galindo, Kirk C. Hansen, Ronald J. Vagnozzi, Katherine E. Yutzey, Jeffery D. Molkentin
Publikováno v:
Cells, Vol 12, Iss 17, p 2174 (2023)
Rationale: The adult cardiac extracellular matrix (ECM) is largely comprised of type I collagen. In addition to serving as the primary structural support component of the cardiac ECM, type I collagen also provides an organizational platform for other
Externí odkaz:
https://doaj.org/article/bc1cebba95e0499bb087b9d6cd86552f
Autor:
Alyssa A. W. Cramer, Vikram Prasad, Einar Eftestøl, Taejeong Song, Kenth-Arne Hansson, Hannah F. Dugdale, Sakthivel Sadayappan, Julien Ochala, Kristian Gundersen, Douglas P. Millay
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Skeletal muscle is composed of syncytial myofibres, each containing hundreds of nuclei. Through genetic reduction of the number of nuclei per myofibre, the authors confirm that more nuclei produce larger cells but myofibres with fewer nuclei adaptive
Externí odkaz:
https://doaj.org/article/906853b2f23840218061a82cb85c451a
Autor:
Michael A. Catalano, BS, Vikram Prasad, MD, Alexander M. Spring, BS, Hugh Cassiere, MD, Tylis Y. Chang, MD, Alan Hartman, MD, Pey-Jen Yu, MD
Publikováno v:
JTCVS Open, Vol 4, Iss , Pp 36-42 (2020)
Objectives: Heparin-induced thrombocytopenia (HIT) is an immune-mediated complication that occurs in a small percentage of patients exposed to heparin. Concerns of HIT are particularly high in patients undergoing cardiac procedures requiring cardiopu
Externí odkaz:
https://doaj.org/article/0ace5d99ad12401da1c9d2127b1c5680
Autor:
Alexander M. Spring, Michael A. Catalano, Vikram Prasad, Bruce Rutkin, Elana Koss, Alan Hartman, Pey-Jen Yu
Publikováno v:
Journal of Interventional Cardiology, Vol 2020 (2020)
Introduction. Requirement of permanent pacemaker (PPM) implantation is a known and common postoperative consequence of transcatheter aortic valve replacement (TAVR). The Emory risk score has been recently developed to help risk stratify the need for
Externí odkaz:
https://doaj.org/article/f6824eb90dae42b48578dd93490551fc
Autor:
Robert N. Correll, Jeffrey M. Lynch, Tobias G. Schips, Vikram Prasad, Allen J. York, Michelle A. Sargent, Didier X. P. Brochet, Jianjie Ma, Jeffery D. Molkentin
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Transverse tubules (t-tubules) are uniquely-adapted membrane invaginations in cardiac myocytes that facilitate the synchronous release of Ca2+ from internal stores and subsequent myofilament contraction, although these structures become diso
Externí odkaz:
https://doaj.org/article/e0793bad17014a878298a6f75b5f43f6
Autor:
Malgorzata E. Quinn, Qingnian Goh, Mitsutoshi Kurosaka, Dilani G. Gamage, Michael J. Petrany, Vikram Prasad, Douglas P. Millay
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Cellular fusion is fundamental for skeletal muscle development. Here the authors show that myomerger is expressed in myoblasts, is essential for myoblast fusion in mice, and in co-operation with myomaker confers fusogenic ability to non-fusogenic cel
Externí odkaz:
https://doaj.org/article/f9517f4aa0cf41ccb0945886204443b1