Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Vikram Alva"'
Autor:
Jan Böhning, Adrian W Dobbelstein, Nina Sulkowski, Kira Eilers, Andriko von Kügelgen, Abul K Tarafder, Sew-Yeu Peak-Chew, Mark Skehel, Vikram Alva, Alain Filloux, Tanmay A M Bharat
Publikováno v:
PLoS Pathogens, Vol 19, Iss 4, p e1011177 (2023)
Chaperone-Usher Pathway (CUP) pili are major adhesins in Gram-negative bacteria, mediating bacterial adherence to biotic and abiotic surfaces. While classical CUP pili have been extensively characterized, little is known about so-called archaic CUP p
Externí odkaz:
https://doaj.org/article/6a6982262fb3416ba14362c4e2da864d
Autor:
Manuel Seefelder, Vikram Alva, Bin Huang, Tatjana Engler, Wolfgang Baumeister, Qiang Guo, Rubén Fernández-Busnadiego, Andrei N. Lupas, Stefan Kochanek
Publikováno v:
BMC Evolutionary Biology, Vol 20, Iss 1, Pp 1-18 (2020)
Abstract Background The huntingtin-associated protein 40 (HAP40) abundantly interacts with huntingtin (HTT), the protein that is altered in Huntington’s disease (HD). Therefore, we analysed the evolution of HAP40 and its interaction with HTT. Resul
Externí odkaz:
https://doaj.org/article/16f3a3a125f343eab0ffd6895c8d452e
Autor:
Janelle Lauer, Sandra Segeletz, Alice Cezanne, Giambattista Guaitoli, Francesco Raimondi, Marc Gentzel, Vikram Alva, Michael Habeck, Yannis Kalaidzidis, Marius Ueffing, Andrei N Lupas, Christian Johannes Gloeckner, Marino Zerial
Publikováno v:
eLife, Vol 8 (2019)
Intracellular trafficking depends on the function of Rab GTPases, whose activation is regulated by guanine exchange factors (GEFs). The Rab5 GEF, Rabex5, was previously proposed to be auto-inhibited by its C-terminus. Here, we studied full-length Rab
Externí odkaz:
https://doaj.org/article/59c0b315ce7c4837876fc46fb806c8fa
Autor:
Evgenia Afanasieva, Indronil Chaudhuri, Jörg Martin, Eva Hertle, Astrid Ursinus, Vikram Alva, Marcus D Hartmann, Andrei N Lupas
Publikováno v:
eLife, Vol 8 (2019)
β-Propellers arise through the amplification of a supersecondary structure element called a blade. This process produces toroids of between four and twelve repeats, which are almost always arranged sequentially in a single polypeptide chain. We foun
Externí odkaz:
https://doaj.org/article/c4e1fb5d59614837a0469c362f45a651
Autor:
Marcin Michalik, Marcella Orwick-Rydmark, Michael Habeck, Vikram Alva, Thomas Arnold, Dirk Linke
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182016 (2017)
An intimate interaction between a pair of amino acids, a tyrosine and glycine on neighboring β-strands, has been previously reported to be important for the structural stability of autotransporters. Here, we show that the conservation of this intera
Externí odkaz:
https://doaj.org/article/0ceb679875ca45818a1d4df7b61e7f44
Publikováno v:
eLife, Vol 4 (2015)
The seemingly limitless diversity of proteins in nature arose from only a few thousand domain prototypes, but the origin of these themselves has remained unclear. We are pursuing the hypothesis that they arose by fusion and accretion from an ancestra
Externí odkaz:
https://doaj.org/article/162344e929f243558c857d5d93c50a09
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27336 (2011)
The linkage of isoprenoid and aromatic moieties, catalyzed by aromatic prenyltransferases (PTases), leads to an impressive diversity of primary and secondary metabolites, including important pharmaceuticals and toxins. A few years ago, a hydroxynapht
Externí odkaz:
https://doaj.org/article/76d2a61949754015883243e0f8fd21f0
Autor:
Andriko von Kügelgen, Sofie van Dorst, Keitaro Yamashita, Danielle L. Sexton, Elitza I. Tocheva, Garib Murshudov, Vikram Alva, Tanmay A. M. Bharat
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Deinococcus radiodurans is an atypical diderm bacterium with a remarkable ability to tolerate various environmental stresses, due in part to its complex cell envelope encapsulated within a hyperstable surface layer (S-layer). Despite decades of resea
Autor:
Yimin Hu, Silvia Deiss, Joe D. Joiner, Marcus D. Hartmann, Andrei N. Lupas, Birte Hernandez Alvarez, Vikram Alva
Histones are DNA-binding proteins that play a crucial role in DNA packaging and gene regulation in eukaryotes and archaea. In eukaryotes, histones form octamers that constitute the core of the nucleosome, the fundamental unit of chromatin. Archaeal h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ca86a1a2833604cd4f44d15d25dbbbf
https://doi.org/10.1101/2023.02.26.530074
https://doi.org/10.1101/2023.02.26.530074
SummaryHomology detection by sequence comparison is a typical first step in the study of protein function and evolution. Here, we describe a new homology detection tool, pLM-BLAST, that uses a modified Smith-Waterman algorithm for unsupervised compar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dcb65e4d2ce4e303f90d61852f631cf
https://doi.org/10.1101/2022.11.24.517862
https://doi.org/10.1101/2022.11.24.517862