Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Vikram, Adhikarla"'
Autor:
Vikram Adhikarla, Dennis Awuah, Enrico Caserta, Megan Minnix, Maxim Kuznetsov, Amrita Krishnan, Jefferey Y. C. Wong, John E. Shively, Xiuli Wang, Flavia Pichiorri, Russell C. Rockne
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionCancer combination treatments involving immunotherapies with targeted radiation therapy are at the forefront of treating cancers. However, dosing and scheduling of these therapies pose a challenge. Mathematical models provide a unique way
Externí odkaz:
https://doaj.org/article/96e8a554e31747d194761070638678f4
Autor:
Mari Amirbekyan, Vikram Adhikarla, Jeffrey P. Cheng, Eleni H. Moschonas, Corina O. Bondi, Russell C. Rockne, Anthony E. Kline, Margarita Gutova
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Efficacious stem cell-based therapies for traumatic brain injury (TBI) depend on successful delivery, migration, and engraftment of stem cells to induce neuroprotection. L-myc expressing human neural stem cells (LMNSC008) demonstrate an inhe
Externí odkaz:
https://doaj.org/article/497892a5a2fe49608a9f57c6a7357a99
Autor:
Margarita Gutova, Jonathan C. Hibbard, Eric Ma, Heini M. Natri, Vikram Adhikarla, Nyam-Osor Chimge, Runxiang Qiu, Cu Nguyen, Elizabeth Melendez, Brenda Aguilar, Renate Starr, Holly Yin, Russel C. Rockne, Masaya Ono, Nicholas E. Banovich, Yate-Ching Yuan, Christine E. Brown, Michael Kahn
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
IntroductionDespite aggressive standard-of-care therapy, including surgery, radiation, and chemotherapy, glioblastoma recurrence is almost inevitable and uniformly lethal. Activation of glioma-intrinsic Wnt/β-catenin signaling is associated with a p
Externí odkaz:
https://doaj.org/article/46059b87db0348ce905d3e52ef396589
Autor:
Alexander B. Brummer, Agata Xella, Ryan Woodall, Vikram Adhikarla, Heyrim Cho, Margarita Gutova, Christine E. Brown, Russell C. Rockne
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
In the development of cell-based cancer therapies, quantitative mathematical models of cellular interactions are instrumental in understanding treatment efficacy. Efforts to validate and interpret mathematical models of cancer cell growth and death h
Externí odkaz:
https://doaj.org/article/3ed9f3f43ccd4e5b86bbe4ee26323978
Autor:
Justin Gomez, Nathanael Holmes, Austin Hansen, Vikram Adhikarla, Margarita Gutova, Russell C. Rockne, Heyrim Cho
Publikováno v:
Mathematical Biosciences and Engineering, Vol 19, Iss 3, Pp 2592-2615 (2022)
Neural stem cells (NSCs) offer a potential solution to treating brain tumors. This is because NSCs can circumvent the blood-brain barrier and migrate to areas of damage in the central nervous system, including tumors, stroke, and wound injuries. Howe
Externí odkaz:
https://doaj.org/article/c6ba8f5edb494d92a971eef08a2c3812
Autor:
Angela M. Jarrett, David A. Hormuth, Vikram Adhikarla, Prativa Sahoo, Daniel Abler, Lusine Tumyan, Daniel Schmolze, Joanne Mortimer, Russell C. Rockne, Thomas E. Yankeelov
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract While targeted therapies exist for human epidermal growth factor receptor 2 positive (HER2 +) breast cancer, HER2 + patients do not always respond to therapy. We present the results of utilizing a biophysical mathematical model to predict tu
Externí odkaz:
https://doaj.org/article/b0d9d0ed140743fbab8a82a362ac28df
Autor:
Jeffrey Y.C. Wong, David M. Yamauchi, Vikram Adhikarla, Jennifer Simpson, Paul H. Frankel, Yuman Fong, Kurt A. Melstrom, Yi-jen Chen, Behrooz D. Salehian, Yanghee Woo, Savita V. Dandapani, David M. Colcher, Erasmus K. Poku, Paul J. Yazaki, Anna M. Wu, John E. Shively
Publikováno v:
Cancer Biotherapy and Radiopharmaceuticals. 38:26-37
Autor:
Margarita Gutova, Jeffrey P. Cheng, Vikram Adhikarla, Lusine Tsaturyan, Michael E. Barish, Russell C. Rockne, Eleni H. Moschonas, Corina O. Bondi, Anthony E. Kline
Publikováno v:
Stem Cells International, Vol 2021 (2021)
As the success of stem cell-based therapies is contingent on efficient cell delivery to damaged areas, neural stem cells (NSCs) have promising therapeutic potential because they inherently migrate to sites of central nervous system (CNS) damage. To e
Externí odkaz:
https://doaj.org/article/8b48aabf33ef4941b4f1114a460aa041
Autor:
Ephraim E. Parent, Marc Benayoun, Ijeoma Ibeanu, Jeffrey J. Olson, Constantinos G. Hadjipanayis, Daniel J. Brat, Vikram Adhikarla, Jonathon Nye, David M. Schuster, Mark M. Goodman
Publikováno v:
EJNMMI Research, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract Background The ability to accurately and non-invasively distinguish high-grade glioma from low-grade glioma remains a challenge despite advances in molecular and magnetic resonance imaging. We investigated the ability of fluciclovine (18F) P
Externí odkaz:
https://doaj.org/article/4fd89adff58342b8944419ace6ce1fb3
Autor:
Vikram Adhikarla, Dennis Awuah, Alexander B. Brummer, Enrico Caserta, Amrita Krishnan, Flavia Pichiorri, Megan Minnix, John E. Shively, Jeffrey Y. C. Wong, Xiuli Wang, Russell C. Rockne
Publikováno v:
Cancers, Vol 13, Iss 20, p 5171 (2021)
Targeted radionuclide therapy (TRT) has recently seen a surge in popularity with the use of radionuclides conjugated to small molecules and antibodies. Similarly, immunotherapy also has shown promising results, an example being chimeric antigen recep
Externí odkaz:
https://doaj.org/article/294fa7e73b9642188fd06ef71a31aa10