Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Vikki M. Weake"'
Autor:
Juan Jauregui-Lozano, Sarah E. McGovern, Kimaya M. Bakhle, Arrianna C. Hagins, Vikki M. Weake
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Studies in multiple organisms have shown that aging is accompanied by several molecular phenotypes that include dysregulation of chromatin. Since chromatin regulates DNA-based processes such as transcription, alterations in chromatin modific
Externí odkaz:
https://doaj.org/article/4af87e1803584cf89e3fbfd97a4bf009
Autor:
Sarah C. Stanhope, Tal Brandwine-Shemmer, Hannah R. Blum, Emma H. Doud, Amber Jannasch, Amber L. Mosley, Baruch Minke, Vikki M. Weake
Publikováno v:
Redox Biology, Vol 63, Iss , Pp 102723- (2023)
The retina is one of the highest oxygen-consuming tissues because visual transduction and light signaling processes require large amounts of ATP. Thus, because of the high energy demand, oxygen-rich environment, and tissue transparency, the eye is su
Externí odkaz:
https://doaj.org/article/a38adced786e401d80ce4ce7f9ef9c3c
Publikováno v:
Fly, Vol 15, Iss 1, Pp 73-88 (2021)
Binary expression systems are a powerful tool for tissue- and cell-specific research. Many of the currently available Drosophila eye-specific drivers have not been systematically characterized for their expression level and cell-type specificity in t
Externí odkaz:
https://doaj.org/article/31b45c20a338412c8b5b59a00eff8c8d
Publikováno v:
BMC Neuroscience, Vol 19, Iss 1, Pp 1-18 (2018)
Abstract Background Light exposure induces oxidative stress, which contributes to ocular diseases of aging. Blue light provides a model for light-induced oxidative stress, lipid peroxidation and retinal degeneration in Drosophila melanogaster. In con
Externí odkaz:
https://doaj.org/article/c0b0fb47d83247cbaed87a8f208c238e
Autor:
Xinping Chen, Hana Hall, Jeffrey P. Simpson, Walter D. Leon-Salas, Donald F. Ready, Vikki M. Weake
Publikováno v:
npj Aging and Mechanisms of Disease, Vol 3, Iss 1, Pp 1-9 (2017)
Neuroscience: Vision is stressful for old flies Paradoxically, light is essential for vision, yet it also induces stress that damages the sensitive cells in the eye. Vikki Weake and her team at Purdue University examined how exposure to blue light ca
Externí odkaz:
https://doaj.org/article/350f1843fb0d44c8be07118b75d08bfb
Autor:
Hana Hall, Patrick Medina, Daphne A. Cooper, Spencer E. Escobedo, Jeremiah Rounds, Kaelan J. Brennan, Christopher Vincent, Pedro Miura, Rebecca Doerge, Vikki M. Weake
Publikováno v:
BMC Genomics, Vol 18, Iss 1, Pp 1-18 (2017)
Abstract Background Aging is associated with functional decline of neurons and increased incidence of both neurodegenerative and ocular disease. Photoreceptor neurons in Drosophila melanogaster provide a powerful model for studying the molecular chan
Externí odkaz:
https://doaj.org/article/4ce92f48e9694b1e8b4132fe5fa8726d
Publikováno v:
HardwareX, Vol 2, Iss C, Pp 13-33 (2017)
A programmable optical stimulator for Drosophila eyes is presented. The target application of the stimulator is to induce retinal degeneration in fly photoreceptor cells by exposing them to light in a controlled manner. The goal of this work is to ob
Externí odkaz:
https://doaj.org/article/e6d5e4136a934899a31af4a4cbc58a36
Autor:
Matthew C. Pharris, Tzu-Ching Wu, Xinping Chen, Xu Wang, David M. Umulis, Vikki M. Weake, Tamara L. Kinzer-Ursem
Publikováno v:
MethodsX, Vol 4, Iss C, Pp 279-288 (2017)
Advanced molecular probing techniques such as single molecule fluorescence in situ hybridization (smFISH) or RNAscope can be used to assess the quantity and spatial location of mRNA transcripts within cells. Quantifying mRNA expression in large image
Externí odkaz:
https://doaj.org/article/32875dd7b3b749329694d550d022bc2f
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 8, Pp 2435-2445 (2016)
The Spt-Ada-Gcn5 Acetyltransferase (SAGA) complex is a transcriptional coactivator with histone acetylase and deubiquitinase activities that plays an important role in visual development and function. In Drosophila melanogaster, four SAGA subunits ar
Externí odkaz:
https://doaj.org/article/68ee993e60ba46c4ad7b50f0441f5052
Autor:
Spencer E. Escobedo, Sarah E. McGovern, Juan P. Jauregui-Lozano, Sarah C. Stanhope, Paul Anik, Kratika Singhal, Ryan DeBernardis, Vikki M. Weake
Publikováno v:
Frontiers in Epigenetics and Epigenomics. 1
Aging is associated with a decline in visual function and increased prevalence of ocular disease, correlating with changes in the transcriptome and epigenome of cells in the eye. Here, we sought to identify the transcriptional mechanisms that are nec