Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Vikki English"'
Autor:
Junping Jing, Laura Bover, C Ian Mockridge, Kerry L Cox, Mark S Cragg, Tatyana Inzhelevskaya, Chris A Penfold, Vikki English, Jane E Willoughby, Hong Shi, Peter J Morley, Heather Jackson, Roopa Srinivasan, Tom Murray, Axel Hoos, Paul Bojczuk, James Smothers, Niranjan Yanamandra, Lang Dou, Sabyasachi Bhattacharya, Laura Seestaller-Wehr, David Kilian, Kui S Voo, Mel John, Heather Niederer, Andrew J Shepherd, Laura Hook, Stephanie Hopley, Sara J Brett, Christopher Hopson, Elaine Paul, Stephen L Martin
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 7 (2024)
Background OX40 has been widely studied as a target for immunotherapy with agonist antibodies taken forward into clinical trials for cancer where they are yet to show substantial efficacy. Here, we investigated potential mechanisms of action of anti-
Externí odkaz:
https://doaj.org/article/1d4a1e220c0f453894379600a08cb4a4
Autor:
Emily R. Webb, Julia Moreno-Vincente, Alistair Easton, Silvia Lanati, Martin Taylor, Sonya James, Emily L. Williams, Vikki English, Chris Penfold, Stephen A. Beers, Juliet C. Gray
Publikováno v:
iScience, Vol 25, Iss 9, Pp 104995- (2022)
Summary: The outcome for children with high-risk neuroblastoma is poor despite intensive multi-modal treatment protocols. Toxicity from current treatments is significant, and novel approaches are needed to improve outcome. Cyclophosphamide (CPM) is a
Externí odkaz:
https://doaj.org/article/202fa5d00d4141d88bafe43b46b1e0e7
Autor:
C Ian Mockridge, Kerry L Cox, Martin J Glennie, Mark S Cragg, Monika Semmrich, Linda Mårtensson, Ingrid Teige, Jordana Griffiths, Khiyam Hussain, Hannah L Smith, Theodore Sanders, Jinny Kim, Tatyana Inzhelevskaya, Chris A Penfold, Alison L Tutt, HT Claude Chan, Vikki English, Ruth F French, Bjorn L Frendeus, Jane E Willoughby
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Background Previous data suggests that anti-OX40 mAb can elicit anti-tumor effects in mice through deletion of Tregs. However, OX40 also has powerful costimulatory effects on T cells which could evoke therapeutic responses. Human trials with anti-OX4
Externí odkaz:
https://doaj.org/article/86d9cb4f413b4935a92592aca78649b9
Autor:
Rachel Fell, Kerry L. Cox, Mark S. Cragg, Thomas Cummin, Peter Johnson, Anna H. Turaj, Lisa Dunning, Tom D Murray, Matthew J. Carter, Vikki English, Graham Packham, Yan Ma, Ben Powell
Publikováno v:
Blood Adv
Although the MYC oncogenic network represents an attractive therapeutic target for lymphoma, MYC inhibitors have been difficult to develop. Alternatively, inhibitors of epigenetic/ transcriptional regulators, particularly the bromodomain and extrater
Autor:
Claude H.T. Chan, Hannah L Smith, Theodore Sanders, Mark S. Cragg, Vikki English, Björn Frendéus, Martin J. Glennie, Ingrid Teige, Jordana Griffiths, Ruth R. French, Khiyam Hussain, Chris Penfold, Kerry L. Cox, Jane E. Willoughby, Tatyana Inzhelevskaya, Alison L. Tutt, Ian M Mockridge, Monika Semmrich, Jinny Kim, Aymen Al-Shamkhani, Linda Mårtensson
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
BackgroundPrevious data suggests that anti-OX40 mAb can elicit anti-tumor effects in mice through deletion of Tregs. However, OX40 also has powerful costimulatory effects on T cells which could evoke therapeutic responses. Human trials with anti-OX40
Autor:
Ann L. White, Mark S. Cragg, Tatyana Inzhelevskaya, H.T. Claude Chan, Ivo Tews, Xiaojie Yu, J. Sjef Verbeek, Leon Douglas, Ruth R. French, Martin J. Glennie, Hayden Fisher, Vikki English, Patrick J. Duriez, Jinny Kim, C. Ian Mockridge, Christine A. Penfold
Publikováno v:
Cancer Cell, 37(6), 850-866.e7. CELL PRESS
Cancer Cell
Cancer Cell
Summary Anti-CD40 monoclonal antibodies (mAbs) comprise agonists and antagonists, which display promising therapeutic activities in cancer and autoimmunity, respectively. We previously showed that epitope and isotype interact to deliver optimal agoni