Zobrazeno 1 - 10 of 24 pro vyhledávání: '"Vikash K. Sinha"'
2
Profiling the dynamics of CSF and plasma Aβ reduction after treatment with JNJ-54861911, a potent oral BACE inhibitor
Autor: Marc Mercken, John Slemmon, Luc Van Nueten, Hans Stieltjes, Bianca Van Broeck, Enchi Liu, John Kemp, Maarten Timmers, Vikash K. Sinha, Jennifer Bogert, Luc Tritsmans, Katja De Waepenaert, Steven Ramael, Dieder Moechars, Sebastiaan Engelborghs, Alberto Russu, Leslie M. Shaw, Johannes Streffer
Publikováno v: Alzheimer's & Dementia : Translational Research & Clinical Interventions
Objectives Safety, tolerability, pharmacokinetics, and pharmacodynamics of a novel β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitor, JNJ-54861911, were assessed after single and multiple dosing in healthy participants. Methods Tw
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::940d96293de7d0f3c049899461840d13
https://doi.org/10.1016/j.trci.2016.08.001
Zobrazit plný text záznamu
3
Translational neurophysiological markers for activity of the metabotropic glutamate receptor (mGluR2) modulator JNJ-40411813: Sleep EEG correlates in rodents and healthy men
Autor: Wilhelmus Drinkenburg, John Kemp, L. Van Nueten, J.M. Cid, L. Raeymaekers, Gregor James Macdonald, T. Van De Casteele, Hilde Lavreysen, H. Huysmans, Vikash K. Sinha, P. de Boer, A. Ahnaou
Publikováno v: Neuropharmacology. 103:290-305
Alterations in rapid eye movement sleep (REM) have been suggested as valid translational efficacy markers: activation of the metabotropic glutamate receptor 2 (mGluR2) was shown to increase REM latency and to decrease REM duration. The present paper
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4a9b26a0aaa8ed8047c35b7b4827d77
https://doi.org/10.1016/j.neuropharm.2015.11.031
Zobrazit plný text záznamu
4
A National Perspective of Do-Not-Resuscitate Order Utilization Predictors in Intracerebral Hemorrhage
Autor: Shiv Kumar Agarwal, Girish N. Nadkarni, Ioannis Konstantinidis, Alexandre M. Benjo, Ambarish Pathak, Krishna Chaitanya Pakanati, Vikash K. Sinha, Narender Annapureddy, Achint Patel, Priya K. Simoes, Vishal Jani, Abhimanyu Mahajan
Publikováno v: The Neurohospitalist. 6:7-10
Nontraumatic intracerebral hemorrhage (ICH) is associated with substantial morbidity and mortality. Do-not-resuscitate (DNR) orders are linked to poorer outcomes in patients with ICH, possibly due to less active management. Demographic, regional, and
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4802eb36ce6e9e2dd4c7c29665571530
https://doi.org/10.1177/1941874415599577
Zobrazit plný text záznamu
5
Pharmacokinetic and pharmacodynamic characterisation of JNJ-40411813, a positive allosteric modulator of mGluR2, in two randomised, double-blind phase-I studies
Autor: Heidi De Smedt, Hiba Salih, Eef Hoeben, Peter de Boer, Ion Anghelescu, Luc Van Nueten, I. Kezic, Vikash K. Sinha
Publikováno v: Journal of Psychopharmacology. 29:414-425
Metabotropic glutamate receptor-2 positive allosteric modulator, JNJ-40411813 (ADX71149), was characterised for clinical effects in healthy volunteers in two phase-1 studies. In study 1, healthy men received 50-, 100-, 150- or 225 mg and women receiv
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99dcc7158f678f9e32b7978ae069560b
https://doi.org/10.1177/0269881115573403
Zobrazit plný text záznamu
6
Molecular Properties Determining Unbound Intracellular and Extracellular Brain Exposure of CNS Drug Candidates
Autor: Carola M. Wassvik, Wilhelmus Drinkenburg, Achiel Van Peer, Margareta Hammarlund-Udenaes, Donald Heald, Irena Loryan, An Vermeulen, Claire Mackie, Vikash K. Sinha
Publikováno v: Molecular Pharmaceutics. 12:520-532
In the present work we sought to gain a mechanistic understanding of the physicochemical properties that influence the transport of unbound drug across the blood-brain barrier (BBB) as well as the intra- and extracellular drug exposure in the brain.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83280db5e59e64b0570893e6a588b655
https://doi.org/10.1021/mp5005965
Zobrazit plný text záznamu
8
From preclinical to human - prediction of oral absorption and drug-drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach in an industrial setting: a workflow by using case example
Autor: Donald Heald, Achiel Van Peer, Nancy Van Osselaer, Vikash K. Sinha, Claire Mackie, Jan Snoeys
Publikováno v: Biopharmaceutics & Drug Disposition. 33:111-121
Purpose A case example is presented in which the physiologically based modeling approach has been used to model the absorption of a lipophilic BCS Class II compound predominantly metabolized by CYP3A4, and to assess the interplay of absorption relate
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::33ebd309af481354fb8b625ae50ab8c2
https://doi.org/10.1002/bdd.1782
Zobrazit plný text záznamu
10
Towards a Better Prediction of Peak Concentration, Volume of Distribution and Half-Life after Oral Drug Administration in Man, Using Allometry
Autor: Luca A. Fenu, Eva Hoeben, Achiel Van Peer, Ron Gilissen, Karin Vaarties, Stefan De Buck, Wendy Sanderson, Marjoleen J.M.A Nijsen, Johan W. Smit, Kelly Van Uytsel, Vikash K. Sinha, Claire Mackie
Publikováno v: Clinical Pharmacokinetics. 50:307-318
Background: It is imperative that new drugs demonstrate adequate pharmacokinetic properties, allowing an optimal safety margin and convenient dosing regimens in clinical practice, which then lead to better patient compliance. Such pharmacokinetic pro
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::759287a16bc429d7831cef21564684ba
https://doi.org/10.2165/11539250-000000000-00000
Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání

Omezení vyhledávání
Plný text Recenzováno Digitální knihovna AV ČR
Zdroje