Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Vikas S. Shirsath"'
Publikováno v:
Annals of Neurosciences
Background : The histamine H3 receptor is an attractive G protein-coupled receptor drug target that regulates neurotransmission in the central nervous system and plays a crucial role in cognitive and homeostatic functions. This receptor exhibits mole
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20dd390013d61ce96b05988e6b3098a0
http://europepmc.org/articles/PMC4117047
http://europepmc.org/articles/PMC4117047
Publikováno v:
European Journal of Medicinal Chemistry. 35:351-358
Anovel series of condensed 3-amino-2-(substituted)methylpyrimidin-4(3H)-ones is reported with potential H(1) receptor antagonistic activity. The IC(50) values for 23 compounds were found to be in the micromolar range. Five lead compounds (10c, e, g,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060b2eb66bc500350698b2e0f4b7ef51
https://doi.org/10.1016/s0223-5234(00)00128-8
https://doi.org/10.1016/s0223-5234(00)00128-8
Publikováno v:
Biochemistry & Analytical Biochemistry.
The range of assay technologies for the binding and signaling has been developed in HTS laboratories for the identification of hit or lead compounds acting on GPCRs. The [ 35 S] GTP γ S binding assay still remains to be a useful and simple technique
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01bf45b2b3a222c2c172a63b979c33ad
https://doi.org/10.4172/2161-1009.1000114
https://doi.org/10.4172/2161-1009.1000114
Publikováno v:
Journal of Drug Metabolism & Toxicology. 3
Imipramine is a renowned tricyclic anti-depressant molecule. It is known to be highly potent and efficient as compared to any other antidepressants available. There are numerous literature reports which elucidate the metabolic pathways of Imipramine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63981af7bd287e2771c38ffece899657
https://doi.org/10.4172/2157-7609.1000126
https://doi.org/10.4172/2157-7609.1000126
Publikováno v:
Journal of Bioequivalence & Bioavailability.
Determining the extent to which a molecule binds to plasma proteins is a critical phase of drug development because the amount of plasma-bound drug influences compound dosing, efficacy, clearance rate and potential for drug interactions. Determinatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74285ed502c1532c8447ff6f6a75d231
https://doi.org/10.4172/jbb.s14-005
https://doi.org/10.4172/jbb.s14-005
Publikováno v:
Alzheimer's & Dementia. 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb872811e65818f151e98bf43b04d9bf
https://doi.org/10.1016/j.jalz.2011.05.2308
https://doi.org/10.1016/j.jalz.2011.05.2308
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2260b26b5013f87b87c181c8df0f6f20
https://doi.org/10.1002/chin.199539181
https://doi.org/10.1002/chin.199539181
Autor:
I. S Rathod, Vikas S. Shirsath, K. S. Jain, U. S. Pathak, Laxmivenkatesh G. Nargund, Hiren Patel, Chamanlal J. Shishoo, Ashok D. Taranalli, Vivek Kumar
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f29d8312927a93cf9f099adda778dc6e
https://doi.org/10.1002/chin.199947167
https://doi.org/10.1002/chin.199947167
Publikováno v:
ChemInform. 31
The synthesis of a series of C(8) unsubstituled (lla-h), C(8) substituted (12a-e ), 8-mercapto (13a-e) 1,3-diaryl-2lhioxanthines, as well as, 8-aza-I,3-diaryl-2-th ioxanthines 14a-g, through precursors, 5,6-diamino-l,3-diaryl-2-thiouracil s 10 has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1032190c9a8aaac7791a43057079cdf
https://doi.org/10.1002/chin.200010145
https://doi.org/10.1002/chin.200010145
Publikováno v:
ChemInform. 31
Anovel series of condensed 3-amino-2-(substituted)methylpyrimidin-4(3H)-ones is reported with potential H(1) receptor antagonistic activity. The IC(50) values for 23 compounds were found to be in the micromolar range. Five lead compounds (10c, e, g,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6141b96caecf2b2402e2a041e0f79a0a
https://doi.org/10.1002/chin.200031167
https://doi.org/10.1002/chin.200031167