Zobrazeno 1 - 10
of 246
pro vyhledávání: '"Vikas P Sukhatme"'
Publikováno v:
JMIR Formative Research, Vol 8, p e51604 (2024)
BackgroundUsing a human-centered design (HCD) approach can provide clinical trial design teams with a better understanding of the needs, preferences, and attitudes of clinical trial stakeholders. It can also be used to understand the challenges and b
Externí odkaz:
https://doaj.org/article/065d689057d44acf80bf8ccf090e9e2f
Autor:
Ramya Ganesan, Swati S Bhasin, Mojtaba Bakhtiary, Upaasana Krishnan, Nagarjuna R Cheemarla, Beena E Thomas, Manoj K Bhasin, Vikas P Sukhatme
Publikováno v:
PLoS Biology, Vol 21, Iss 9, p e3002275 (2023)
A major cause of cancer recurrence following chemotherapy is cancer dormancy escape. Taxane-based chemotherapy is standard of care in breast cancer treatment aimed at killing proliferating cancer cells. Here, we demonstrate that docetaxel injures str
Externí odkaz:
https://doaj.org/article/6859078ccfb9422a941de4b39a3b32a9
Publikováno v:
PLoS ONE, Vol 5, Iss 9 (2010)
Malic enzyme 2 (ME2) is a mitochondrial enzyme that catalyzes the conversion of malate to pyruvate and CO2 and uses NAD as a cofactor. Higher expression of this enzyme correlates with the degree of cell de-differentiation. We found that ME2 is expres
Externí odkaz:
https://doaj.org/article/b6e91d2209f1407cb38136e0d4f603c4
Autor:
Samir M Parikh, Tadanori Mammoto, Aylit Schultz, Hai-Tao Yuan, David Christiani, S Ananth Karumanchi, Vikas P Sukhatme
Publikováno v:
PLoS Medicine, Vol 3, Iss 3, p e46 (2006)
BACKGROUND: Acute respiratory distress syndrome (ARDS) is a devastating complication of numerous underlying conditions, most notably sepsis. Although pathologic vascular leak has been implicated in the pathogenesis of ARDS and sepsis-associated lung
Externí odkaz:
https://doaj.org/article/62f48ca3a3d04e839e56157a268eb37b
Autor:
Nikhil T. Sebastian, William A. Stokes, Madhusmita Behera, Renjian Jiang, David A. Gutman, Zhonglu Huang, Abigail Burns, Vidula Sukhatme, Michael C. Lowe, Suresh S. Ramalingam, Vikas P. Sukhatme, Drew Moghanaki
Publikováno v:
Clinical Lung Cancer. 24:287-294
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7af26907b44dc21240dc7af2c9ddf8e5
https://doi.org/10.1016/j.cllc.2022.12.013
https://doi.org/10.1016/j.cllc.2022.12.013
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Fluvoxamine is a well-tolerated, widely available, inexpensive selective serotonin reuptake inhibitor that has been shown in a small, double-blind, placebo-controlled, randomized study to prevent clinical deterioration of patients with mild coronavir
Externí odkaz:
https://doaj.org/article/b2d7d22d0c02487ca0e0e5efb9092901
Autor:
Jian-Guo Ren, Pankaj Seth, Huihui Ye, Kun Guo, Jun-ichi Hanai, Zaheed Husain, Vikas P. Sukhatme
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract In this study we have tested the efficacy of citrate therapy in various cancer models. We found that citrate administration inhibited A549 lung cancer growth and additional benefit accrued in combination with cisplatin. Interestingly, citrat
Externí odkaz:
https://doaj.org/article/3acbcb82668747168191a6e029a8aad7
Autor:
William A. Stokes, Madhusmita Behera, Renjian Jiang, David A. Gutman, Zhonglu Huang, Abigail Burns, Nikhil T. Sebastian, Vidula Sukhatme, Michael C. Lowe, Suresh S. Ramalingam, Vikas P. Sukhatme, Drew Moghanaki
Publikováno v:
Cancer Medicine. 12:358-367
Peroxisome proliferator-activated receptor agonists such as fibrates restore oxidative metabolism in cytotoxic T-lymphocytes, thereby enhancing response to immune checkpoint inhibitors (ICI) in preclinical models. However, there is no evidence in hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0d7a955da7505372b2d946b74b531f
https://doi.org/10.1002/cam4.4847
https://doi.org/10.1002/cam4.4847
Autor:
Ramya Ganesan, Swati S. Bhasin, Upaasana Krishnan, Nagarjuna R. Cheemarla, Beena E. Thomas, Manoj K. Bhasin, Vikas P. Sukhatme
A major cause of cancer recurrence following chemotherapy is cancer dormancy escape. Taxane-based chemotherapy is standard of care in breast cancer treatment aimed at killing proliferating cancer cells. Here, we demonstrate that docetaxel injures str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4cbfd5b554d2aefeea7a6216d77ff34
https://doi.org/10.1101/2022.07.10.499472
https://doi.org/10.1101/2022.07.10.499472
Autor:
Jocelin Pinto, Cody Callahan, Gerburg M. Wulf, Gopal Varma, Vikas P. Sukhatme, Manushka Vaidya, Pankaj Seth, Patricia Coutinho de Souza, Aaron K. Grant, Olmo Sonzogni
Publikováno v:
NMR Biomed
In many tumors, cancer cells take up large quantities of glucose and metabolize it into lactate, even in the presence of sufficient oxygen to support oxidative metabolism. It has been hypothesized that this malignant metabolic phenotype supports canc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e964574590786cdf04a3daead25e5a25
https://doi.org/10.1002/nbm.4560
https://doi.org/10.1002/nbm.4560