Zobrazeno 1 - 10
of 361
pro vyhledávání: '"Vikas P Sukhatme"'
Publikováno v:
JMIR Formative Research, Vol 8, p e51604 (2024)
BackgroundUsing a human-centered design (HCD) approach can provide clinical trial design teams with a better understanding of the needs, preferences, and attitudes of clinical trial stakeholders. It can also be used to understand the challenges and b
Externí odkaz:
https://doaj.org/article/065d689057d44acf80bf8ccf090e9e2f
Autor:
Merissa Coleman, Sophia J. Mascialino, Anusha Panjwani, Emily Edwards, Vidula V. Sukhatme, Christina Gavegnano, Vikas P. Sukhatme
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
To improve the efficacy of immune checkpoint inhibitors (ICIs) for cancer treatment, various strategies, including combination therapies with repurposed drugs, are being explored. Several readily available interventions with potential to enhance prog
Externí odkaz:
https://doaj.org/article/cc7e38a31e3f4e308b58d133fde48ecf
Autor:
William A. Stokes, Madhusmita Behera, Renjian Jiang, David A. Gutman, Zhonglu Huang, Abigail Burns, Nikhil T. Sebastian, Vidula Sukhatme, Michael C. Lowe, Suresh S. Ramalingam, Vikas P. Sukhatme, Drew Moghanaki
Publikováno v:
Cancer Medicine, Vol 12, Iss 1, Pp 358-367 (2023)
Abstract Background Peroxisome proliferator‐activated receptor agonists such as fibrates restore oxidative metabolism in cytotoxic T‐lymphocytes, thereby enhancing response to immune checkpoint inhibitors (ICI) in preclinical models. However, the
Externí odkaz:
https://doaj.org/article/38bd7141aeb7447eb83d8b4d4ffa906d
Autor:
Ramya Ganesan, Swati S Bhasin, Mojtaba Bakhtiary, Upaasana Krishnan, Nagarjuna R Cheemarla, Beena E Thomas, Manoj K Bhasin, Vikas P Sukhatme
Publikováno v:
PLoS Biology, Vol 21, Iss 9, p e3002275 (2023)
A major cause of cancer recurrence following chemotherapy is cancer dormancy escape. Taxane-based chemotherapy is standard of care in breast cancer treatment aimed at killing proliferating cancer cells. Here, we demonstrate that docetaxel injures str
Externí odkaz:
https://doaj.org/article/6859078ccfb9422a941de4b39a3b32a9
Autor:
Nikhil T. Sebastian, William A. Stokes, Madhusmita Behera, Renjian Jiang, David A. Gutman, Zhonglu Huang, Abigail Burns, Vidula Sukhatme, Michael C. Lowe, Suresh S. Ramalingam, Vikas P. Sukhatme, Drew Moghanaki
Publikováno v:
Clinical Lung Cancer. 24:287-294
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7af26907b44dc21240dc7af2c9ddf8e5
https://doi.org/10.1016/j.cllc.2022.12.013
https://doi.org/10.1016/j.cllc.2022.12.013
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Fluvoxamine is a well-tolerated, widely available, inexpensive selective serotonin reuptake inhibitor that has been shown in a small, double-blind, placebo-controlled, randomized study to prevent clinical deterioration of patients with mild coronavir
Externí odkaz:
https://doaj.org/article/b2d7d22d0c02487ca0e0e5efb9092901
Autor:
Jian-Guo Ren, Pankaj Seth, Huihui Ye, Kun Guo, Jun-ichi Hanai, Zaheed Husain, Vikas P. Sukhatme
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
Abstract In this study we have tested the efficacy of citrate therapy in various cancer models. We found that citrate administration inhibited A549 lung cancer growth and additional benefit accrued in combination with cisplatin. Interestingly, citrat
Externí odkaz:
https://doaj.org/article/3acbcb82668747168191a6e029a8aad7
Autor:
William A. Stokes, Madhusmita Behera, Renjian Jiang, David A. Gutman, Zhonglu Huang, Abigail Burns, Nikhil T. Sebastian, Vidula Sukhatme, Michael C. Lowe, Suresh S. Ramalingam, Vikas P. Sukhatme, Drew Moghanaki
Publikováno v:
Cancer Medicine. 12:358-367
Peroxisome proliferator-activated receptor agonists such as fibrates restore oxidative metabolism in cytotoxic T-lymphocytes, thereby enhancing response to immune checkpoint inhibitors (ICI) in preclinical models. However, there is no evidence in hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e0d7a955da7505372b2d946b74b531f
https://doi.org/10.1002/cam4.4847
https://doi.org/10.1002/cam4.4847
Autor:
Ramya Ganesan, Swati S. Bhasin, Upaasana Krishnan, Nagarjuna R. Cheemarla, Beena E. Thomas, Manoj K. Bhasin, Vikas P. Sukhatme
A major cause of cancer recurrence following chemotherapy is cancer dormancy escape. Taxane-based chemotherapy is standard of care in breast cancer treatment aimed at killing proliferating cancer cells. Here, we demonstrate that docetaxel injures str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4cbfd5b554d2aefeea7a6216d77ff34
https://doi.org/10.1101/2022.07.10.499472
https://doi.org/10.1101/2022.07.10.499472
Autor:
Pankaj Seth, Aaron Grant, Jian Tang, Elena Vinogradov, Xioaen Wang, Robert Lenkinski, Vikas P. Sukhatme
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 13, Iss 1, Pp 60-71 (2011)
Many cancer cells display the Warburg effect, that is, enhanced glycolysis followed by fermentation (conversion of pyruvate to lactate). Recently, the molecular basis for these effects has started to be elucidated, and the upregulation of the lactate
Externí odkaz:
https://doaj.org/article/fdcb5cfc0a074f4b8166eeb7a85552bd