Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Vikas, Karande"'
Autor:
Nagaraj Gowda, Sanjib Das, Sravan Mandadi, Jagmohan Saini, Sachin Chaudhari, Ameya Deshpande, Murugan Chinnapattu, Malini Bajpai, Priyanka Pangre, Varada Potdar, Megha Marathe, Pooja Sawant, Atul Akarte, Chandrasekhar Misra, Subhadip Das, Anuj Singh, Avratanu Das, Pandurang Lambade, Chaitanya Tirumalasetty, Raju Patole, Nilanjana Biswas, Vikas Karande, Heta Shah, Dayanidhi Behera, Pravin Iyer
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/3b4b03f862394120b275158b7a6d0779
Autor:
Murugan Chinnapattu, Sandeep Shelke, Prashant Ingale, Nayan Waghmare, Nanasaheb Kadlag, Manoj Pawar, Akshay Kangane, Sachin S. Chaudhari, Jagmohan Saini, Vidya Kattige, Arti Joshi, Colina Dutta, Debjyoti Boral, Sheetal Kadam, Varada Potdar, Jiju Mani, Pooja Sawant, Megha Marathe, Madhavi Mulay, Akshata Virdikar, Sravan Mandadi, Atul Akarte, Anuj Singh, Chandrasekhar Misra, Pandurang Lambade, Chaitanya Tirumalasetty, Raju Patole, Vikas Karande, Dayanidhi Behera, Pankaj Jain, Vishwanath Kurawattimath, Nagaraj Gowda, Pravin S. Iyer
Publikováno v:
Cancer Research. 83:462-462
Background: Casitas B-lineage lymphoma b (Cbl-b), a RING finger E3 ligase, is a negative regulator of immune cell activation1. Genetic deletion or pharmacological inhibition of Cbl-b resulted in hyper-reactive and co-stimulation independent T cell ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fa2beeb2c291d8d6b09cbab0e14b63d
https://doi.org/10.1158/1538-7445.am2023-462
https://doi.org/10.1158/1538-7445.am2023-462
Autor:
Sravan Mandadi, Sanjib Das, Malini Bajpai, Jagmohan Saini, Murugan Chinnapattu, Sanjay Patale, Sandip Patil, Nanasaheb Kadlag, Nayan Waghmare, Balasaheb Gavhane, Ameya Deshpande, Dnyaneshwar Dahale, Vidya Kattige, Priyanka Pangre, Namrata Singh, Ekta Kashyap, Megha Marathe, Jiju Mani, Atul Akarte, Chandrasekhar Misra, Subhadip Das, Anuj Singh, Pandurang Lambade, Avratanu Das, Chaitanya Tirumalasetty, Raju Patole, Nilanjana Biswas, Vikas Karande, Heta Shah, Dayanidhi Behera, Pankaj Jain, Pavankumar Sancheti, Pramod Pawar, Vinod KR, Venkatesha Udupa, Sachin S. Chaudhari, Nagaraj Gowda, Pravin S. Iyer
Publikováno v:
Cancer Research. 83:463-463
Background: Pre-clinical profile of GRC 54276, a clinical candidate with Phase 1/2 clinical trial ongoing, is presented here. GRC 54276 is a novel small molecule inhibitor of Hematopoietic progenitor kinase 1 (HPK1), a serine/threonine kinase1,2 that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db14602386eb472679cd4689f7bc1915
https://doi.org/10.1158/1538-7445.am2023-463
https://doi.org/10.1158/1538-7445.am2023-463
Publikováno v:
Journal of Entomology and Zoology Studies. 10:52-53
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7cab41b3bee7fbfbfc29d810b08df74a
https://doi.org/10.22271/j.ento.2022.v10.i4a.9034
https://doi.org/10.22271/j.ento.2022.v10.i4a.9034
Autor:
Pooja Sawant, Ameya Deshpande, Pravin Iyer, Nagaraj Gowda, Avratanu Das, Megha Marathe, Dayanidhi Behera, Subhadip Das, Sravan Mandadi, Nilanjana Biswas, Priyanka Pangre, Heta Shah, Raju Patole, Murugan Chinnapattu, Vikas Karande, Sanjib Das, Pandurang Lambade, Sachin Sundarlal Chaudhari, Chandrasekhar Misra, Anuj Singh, Chaitanya Tirumalasetty, Jagmohan S. Saini, Varada Potdar, Malini Bajpai, Atul Akarte
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundHematopoietic progenitor kinase 1 (HPK1, MAP4K1), is a negative regulator of T and B cell receptor signaling.1 2 3 A strong anti-tumor immunogenic response and tumor rejection was observed in mice with HPK1 gene knocked out.3 Treatment of H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f91267a108a556ecb9933823dc346792
https://doaj.org/article/3b4b03f862394120b275158b7a6d0779
https://doaj.org/article/3b4b03f862394120b275158b7a6d0779
Autor:
Sravan Mandadi, Sanjib Das, Jagmohan Saini, Sachin S. Chaudhari, Murugan Chinnapattu, Ameya Deshpande, Dnyaneshwar Dahale, Malini Bajpai, Priyanka Pangre, Namrata Singh, Ekta Kashyap, Megha Marathe, Jiju Mani, Atul Akarte, Chandrasekhar Misra, Subhadip Das, Anuj Singh, Avratanu Das, Pandurang Lambade, Chaitanya Tirumalasetty, Raju Patole, Nilanjana Biswas, Vikas Karande, Heta Shah, Dayanidhi Behera, Pankaj Jain, Pavankumar Sancheti, Somesh Kakade, Pramod K. Pawar, Vinod KR, Venkatesha Udupa, Nagaraj Gowda, Pravin S. Iyer
Publikováno v:
Cancer Research. 82:1804-1804
Background Hematopoietic progenitor kinase 1 (HPK1) is a member of the mitogen-activated protein kinase (MAP4K) family of protein serine/threonine kinases1,2 and is a negative regulator of T and B cell receptor signaling3. Inhibition of HPK1 is an at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd63fad1d55c76e5ad29fc516339ed2c
https://doi.org/10.1158/1538-7445.am2022-1804
https://doi.org/10.1158/1538-7445.am2022-1804
Autor:
Vidya Ganapati Kattige, Srinivasa Honnegowda, Sanjay Deshmukh, Laxmikant Atmaram Gharat, Abhay Kulkarni, Neelam Sarode, Pooja Sawant, Shital Tondlekar, Neelima Khairatkar-Joshi, Vikas Karande, Dnyandeo Pisal, Satyawan Jadhav, Macchindra Tambe, Nagarajan Muthukaman, Mahamadhanif S. Shaikh, Ramchandra R. Sangana, Monali Pisat, Girish S. Gudi, Dayanidhi Behera
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:5131-5138
This letter describes the synthesis and biological evaluation of furan and dihydrofuran-fused tricyclic benzo[d]imidazole derivatives as novel mPGES-1 inhibitors, capable of inhibiting an increased PGE2 production in the disease state. Structure-acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c711ec94b372ec3592b14b193fefd59c
https://doi.org/10.1016/j.bmcl.2017.10.062
https://doi.org/10.1016/j.bmcl.2017.10.062
Autor:
Azfar Quraishi, Abhay Kulkarni, Vidya Ramdas, Sreekanth R. Rouduri, Sujay Basu, Yogesh Waman, Vaibhav Jain, Anil Panmand, Vandna Prasad, Arnab Goswami, Sachin Thorat, Meena Patel, Anita Chugh, Santosh Kumar, B. Srinivasa Reddy, Syed Mustafa, Sandhya Chaturvedi, Kasim A. Mookhtiar, Siddhartha De, Ena Ray Banerjee, Suraj Menon, Minakshi Naykodi, Shalini Paliwal, Venkata P. Palle, Vikas Karande, Indraneel Ghosh, Dinesh A. Barawkar
Publikováno v:
European Journal of Medicinal Chemistry. 134:218-229
Adenosine induces bronchial hyperresponsiveness and inflammation in asthmatics through activation of A2B adenosine receptor (A2BAdoR). Selective antagonists have been shown to attenuate airway reactivity and improve inflammatory conditions in pre-cli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5c77591350a111c2a6947f52eca0e5e
https://doi.org/10.1016/j.ejmech.2017.04.014
https://doi.org/10.1016/j.ejmech.2017.04.014
Autor:
Srinivasa Honnegowda, Shital Tondlekar, Dnyandeo Pisal, Abhay Kulkarni, Dayanidhi Behera, Girish S. Gudi, Laxmikant Atmaram Gharat, Macchindra Tambe, Nagarajan Muthukaman, Sanjay Deshmukh, Satyawan Jadhav, Jitendra Maganbhai Gajera, Neelam Sarode, Mahamadhanif S. Shaikh, Vikas Karande, Lakshminarayana Narayana, Vidya Ganapati Kattige, Neelima Khairatkar-Joshi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:2594-2601
A series of substituted tricyclic 4,4-dimethyl-3,4-dihydrochromeno[3,4-d]imidazole derivatives have been synthesized and their mPGES-1 biological activity has been disclosed in detail. Structure-activity relationship (SAR) optimization provided inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c3194769e93c1e5b342652115b63fe7
https://doi.org/10.1016/j.bmcl.2017.03.068
https://doi.org/10.1016/j.bmcl.2017.03.068
Autor:
Venkata P. Palle, Dinesh A. Barawkar, Vandna Prasad, Santosh Kumar, Sachin Thorat, Sreekanth R. Rouduri, Sushant Dusange, Yogesh Waman, Arnab Goswami, Anita Chugh, B. Srinivasa Reddy, Kasim A. Mookhtiar, Anil Panmand, Gaurav Bedse, Rajesh Bonagiri, Azfar Quraishi, Vikas Karande, Vidya Ramdas, Meena Patel, Indraneel Ghosh, Rhishikesh Thakre, Sujay Basu, Shalini Paliwal, Dilip Jadhav, Sandhya Chaturvedi, Partha P. Mukhopadhyay, Abhay Kulkarni, Jayasagar Gundu, Suraj Menon
Publikováno v:
European Journal of Medicinal Chemistry. 127:986-996
A2BAdoR is a low affinity adenosine receptor that functions by Gs mediated elevation of cAMP and subsequent downstream signaling. The receptor has been implicated in lung inflammatory disorders like COPD and asthma. Several potent and selective A2BAd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ed32bbc23dd3e7768f4a309c4f2bc4e
https://doi.org/10.1016/j.ejmech.2016.11.007
https://doi.org/10.1016/j.ejmech.2016.11.007