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Lumacaftor/ivacaftor changes the lung microbiome and metabolome in cystic fibrosis patients

Autor: Neerincx, Anne H., Whiteson, Katrine, Phan, Joann L., Brinkman, Paul, Abdel-Aziz, Mahmoud I., Weersink, Els J.M., Altenburg, Josje, Majoor, Christof J., Maitland-van der Zee, Anke H., Bos, Lieuwe D.J., Haarman, E., Rutjes, N. W., Terheggen-Lagro, S. W.J., Seljogi, D., Kemper, E. M., Lutter, R., Vijverberg, S. J., Vonk, S. E.M., Adriaens, N., Lub, R., van Brederode, M., van der Schaaf, L., Verkleij, M., van Gilst, N. A., Hofsteenge, G. H., Brackel, C. L.H., Lakeman, P., Bon, I. C.M., Tanner, S. P.M., Sterk, P. J., Longo, C., Sinha, A., Fenn, D., Lammers, A., Richards, L. B., van Bragt, J. M., Kos, R., Dagelet, J. W.F., Lone-Latif, S. J.A., Schultz, M. J., Smit, M. R., Hagens, L. A.

Publikováno v: Neerincx, A H, Whiteson, K, Phan, J L, Brinkman, P, Abdel-Aziz, M I, Weersink, E J M, Altenburg, J, Majoor, C J, Maitland-van der Zee, A H, Bos, L D J, Haarman, E, Rutjes, N W, Terheggen-Lagro, S W J, Seljogi, D, Kemper, E M, Lutter, R, Vijverberg, S J, Vonk, S E M, Adriaens, N, Lub, R, van Brederode, M, van der Schaaf, L, Verkleij, M, van Gilst, N A, Hofsteenge, G H, Brackel, C L H, Lakeman, P, Bon, I C M, Tanner, S P M, Sterk, P J, Longo, C, Sinha, A, Fenn, D, Lammers, A, Richards, L B, van Bragt, J M, Kos, R, Dagelet, J W F, Lone-Latif, S J A, Schultz, M J, Smit, M R, Hagens, L A, Amsterdam mucociliary clearance disease research group & Amsterdam UMC Breath Research Group 2021, ' Lumacaftor/ivacaftor changes the lung microbiome and metabolome in cystic fibrosis patients ', ERJ Open Research, vol. 7, no. 2, 00731-2020 . https://doi.org/10.1183/23120541.00731-2020
ERJ Open Research, 7(2):00731-2020. BMJ Publishing Group
ERJ Open Research
article-version (VoR) Version of Record
ERJ open research, 7(2):00731-2020. European Respiratory Society
ERJ Open Research, Vol 7, Iss 2 (2021)

Rationale Targeted cystic fibrosis (CF) therapy with lumacaftor/ivacaftor partly restores chloride channel function and improves epithelial fluid transport in the airways. Consequently, changes may occur in the microbiome, which is adapted to CF lung

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ab579d0ee582c686532e1520e3205a9
https://research.vumc.nl/en/publications/cdb44a8a-7c3d-44d5-8941-b1e909993ffb

Effects of short-term exposures to ultrafine particles near an airport in healthy subjects

Autor: Lammers, A, Janssen, N A H, Boere, A J F, Berger, M, Longo, C, Vijverberg, S J H, Neerincx, A H, Maitland-van der Zee, A H, Cassee, F R, IRAS OH Toxicology, dIRAS RA-1

Publikováno v: Environment international, 141:105779. Elsevier Limited
Environment international, 141. Elsevier Limited
Environment International, Vol 141, Iss, Pp 105779-(2020)

BACKGROUND: Recent studies reported elevated concentrations of ultrafine particles (UFP) near airports. Little is known about the health effects of UFP from aviation. Since UFP can deposit deep into the lungs and other organs, they may cause signific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be937560a10fe3aa6c8515b7f51e01a
https://pubmed.ncbi.nlm.nih.gov/32402984

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Atopic dermatitis characteristics and medication-use patterns in school-age children with AD and asthma symptoms

Autor: Lee, M.M., Arabkhazaeli, A, van Erp, Francine C., Raaijmakers, J A, van der Ent, Cornelis K, Bruijnzeel-Koomen, Carla A F M, de Bruin-Weller, M.S., Vijverberg, S J H, Maitland-van der Zee, A H, Afd Pharmacoepi & Clinical Pharmacology, Pharmacoepidemiology and Clinical Pharmacology

Publikováno v: Clinical and Experimental Dermatology, 42(5), 503. Wiley-Blackwell Publishing Ltd
Clinical and experimental dermatology, 42(5), 503. Wiley-Blackwell
Clinical and experimental dermatology, 42(5), 503-508. Wiley-Blackwell

Background: Atopic dermatitis (AD) and asthma often coexist. Both diseases can have a major impact on the lives of children with AD and their caregivers. Aim: To investigate the association of patient characteristics, comorbidities and impact of AD o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0c76fe990b6795d9849dc99e02c3183
https://doi.org/10.1111/ced.13111