Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Viji Nair"'
Autor:
Felix Keller, Sara Denicolò, Johannes Leierer, Maren Kruus, Andreas Heinzel, Michael Kammer, Wenjun Ju, Viji Nair, Frederic Burdet, Mark Ibberson, Rajasree Menon, Edgar Otto, Ye Ji Choi, Laura Pyle, Patricia Ladd, Petter M. Bjornstad, Susanne Eder, Laszlo Rosivall, Patrick Barry Mark, Andrzej Wiecek, Hiddo J. Lamber Heerspink, Matthias Kretzler, Rainer Oberbauer, Gert Mayer, Paul Perco
Publikováno v:
Kidney & Blood Pressure Research, Pp 1-21 (2024)
Introduction Diabetic kidney disease (DKD) is a common cause of chronic kidney disease with around 25-40% of patients with diabetes being affected. The course of DKD is variable and estimated glomerular filtration rate (eGFR) and albuminuria, the cur
Externí odkaz:
https://doaj.org/article/23e045abb5ea4f278268803152b64de8
Autor:
Shuya Liu, Yu Zhao, Shun Lu, Tianran Zhang, Maja T. Lindenmeyer, Viji Nair, Sydney E. Gies, Guochao Wu, Robert G. Nelson, Jan Czogalla, Hande Aypek, Stephanie Zielinski, Zhouning Liao, Melanie Schaper, Damian Fermin, Clemens D. Cohen, Denis Delic, Christian F. Krebs, Florian Grahammer, Thorsten Wiech, Matthias Kretzler, Catherine Meyer-Schwesinger, Stefan Bonn, Tobias B. Huber
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-19 (2023)
Abstract Background Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, and histopathologic glomerular lesions are among the earliest structural alterations of DN. However, the signaling pathways that initiate these glomerular
Externí odkaz:
https://doaj.org/article/df3b8422c172486d90e70dad5e72e7ce
Autor:
Laura J. Smyth, Emma H. Dahlström, Anna Syreeni, Katie Kerr, Jill Kilner, Ross Doyle, Eoin Brennan, Viji Nair, Damian Fermin, Robert G. Nelson, Helen C. Looker, Christopher Wooster, Darrell Andrews, Kerry Anderson, Gareth J. McKay, Joanne B. Cole, Rany M. Salem, Peter J. Conlon, Matthias Kretzler, Joel N. Hirschhorn, Denise Sadlier, Catherine Godson, Jose C. Florez, GENIE consortium, Carol Forsblom, Alexander P. Maxwell, Per-Henrik Groop, Niina Sandholm, Amy Jayne McKnight
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Approximately 40 percent of people with type 1 diabetes develop kidney disease, but the risk factors are not well understood. Here, the authors identify DNA methylation signatures associated with diabetic kidney disease, of which 21 biomarkers predic
Externí odkaz:
https://doaj.org/article/777a9666411244d6bce4bb7f84d0b5c3
Autor:
Jennifer A. Schaub, Fadhl M. AlAkwaa, Phillip J. McCown, Abhijit S. Naik, Viji Nair, Sean Eddy, Rajasree Menon, Edgar A. Otto, Dawit Demeke, John Hartman, Damian Fermin, Christopher L. O’Connor, Lalita Subramanian, Markus Bitzer, Roger Harned, Patricia Ladd, Laura Pyle, Subramaniam Pennathur, Ken Inoki, Jeffrey B. Hodgin, Frank C. Brosius III, Robert G. Nelson, Matthias Kretzler, Petter Bjornstad
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 5 (2023)
The molecular mechanisms of sodium-glucose cotransporter-2 (SGLT2) inhibitors (SGLT2i) remain incompletely understood. Single-cell RNA sequencing and morphometric data were collected from research kidney biopsies donated by young persons with type 2
Externí odkaz:
https://doaj.org/article/786e05c40b544ed683f2bef88a499a82
Autor:
Abigail R. Smith, Jarcy Zee, Nan Ji, Jonathan P. Troost, Brenda W. Gillespie, Viji Nair, Qian Liu, Keisha L. Gibson, Matthias Kretzler, Laura H. Mariani
Publikováno v:
Kidney Medicine, Vol 2, Iss 4, Pp 407-417 (2020)
Rationale & Objective: Surrogate outcomes for end-stage kidney disease often assume linear changes, which may not reflect true estimated glomerular filtration rate (eGFR) trajectories. This study’s objective was to characterize nonlinear eGFR traje
Externí odkaz:
https://doaj.org/article/46b7d5b88fef4aebb964dfc28c027417
Autor:
Sara Denicolò, Viji Nair, Johannes Leierer, Michael Rudnicki, Matthias Kretzler, Gert Mayer, Wenjun Ju, Paul Perco
Publikováno v:
Biomolecules, Vol 13, Iss 1, p 89 (2022)
Fibrinogen-like 2 (FGL2) was recently found to be associated with fibrosis in a mouse model of kidney damage and was proposed as a potential therapeutic target in chronic kidney disease (CKD). We assessed the association of renal FGL2 mRNA expression
Externí odkaz:
https://doaj.org/article/2b55ea9ed8944b0b9b09a2924badd4d2
Autor:
Kelli M. Sas, Jiahe Lin, Thekkelnaycke M. Rajendiran, Tanu Soni, Viji Nair, Lucy M. Hinder, Hosagrahar V. Jagadish, Thomas W. Gardner, Steven F. Abcouwer, Frank C. Brosius, III, Eva L. Feldman, Matthias Kretzler, George Michailidis, Subramaniam Pennathur
Publikováno v:
Journal of Lipid Research, Vol 59, Iss 2, Pp 173-183 (2018)
Lipids are ubiquitous metabolites with diverse functions; abnormalities in lipid metabolism appear to be related to complications from multiple diseases, including type 2 diabetes. Through technological advances, the entire lipidome has been characte
Externí odkaz:
https://doaj.org/article/ba85df96d23e4dfc9895cf6bfd30b5d5
Autor:
Bo Zeng, Gui-Lan Chen, Eliana Garcia-Vaz, Sunil Bhandari, Nikoleta Daskoulidou, Lisa M. Berglund, Hongni Jiang, Thomas Hallett, Lu-Ping Zhou, Li Huang, Zi-Hao Xu, Viji Nair, Robert G. Nelson, Wenjun Ju, Matthias Kretzler, Stephen L. Atkin, Maria F. Gomez, Shang-Zhong Xu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Patients with diabetic nephropathy suffer from impaired albumin reabsorption by proximal tubular epithelial cells. Here authors use diabetic and transgenic mouse models and in vitro models to show the cause for this lies in the down regulation and in
Externí odkaz:
https://doaj.org/article/d6d1cb0bcd8f49c9b88f64376cab64f6
Autor:
Brad P Dieter, Rick L Meek, Robert J Anderberg, Sheryl K Cooney, Jen L Bergin, Hongyu Zhang, Viji Nair, Matthias Kretzler, Frank C Brosius, Katherine R Tuttle
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0211555 (2019)
BackgroundSerum amyloid A (SAA), a potent inflammatory mediator, and Janus kinase 2 (JAK2), an intracellular signaling kinase, are increased by diabetes. The aims were to elucidate: 1) a JAK2-mediated pathway for increased SAA in the kidneys of diabe
Externí odkaz:
https://doaj.org/article/0821f4b6cda849aba7b4afc4d70f4719
Autor:
Lilian Otalora, Efren Chavez, Daniel Watford, Lissett Tueros, Mayrin Correa, Viji Nair, Philip Ruiz, Patricia Wahl, Sean Eddy, Sebastian Martini, Matthias Kretzler, George W Burke, Alessia Fornoni, Sandra Merscher
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0222948 (2019)
Focal segmental glomerulosclerosis (FSGS) accounts for about 40% of all nephrotic syndrome cases in adults. The presence of several potential circulating factors has been suggested in patients with primary FSGS and particularly in patients with recur
Externí odkaz:
https://doaj.org/article/2fbf49be4afb435e822895e4f27ecea8