Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Viji M. Draviam"'
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109007- (2024)
Summary: Chromosomal instability (CIN) is a hallmark of cancers, and CIN-promoting mutations are not fully understood. Here, we report 141 chromosomal instability aiding variant (CIVa) candidates by assessing the prevalence of loss-of-function (LoF)
Externí odkaz:
https://doaj.org/article/1e0e32715fda4fc48c04d567eae83dec
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Chromosome instability frequently occurs due to issues with chromosome-microtubule attachments. Here the authors show that the Astrin-PP1 and Cyclin-B-CDK1 pathways counteract each other to protect chromosome-microtubule attachments independent of bi
Externí odkaz:
https://doaj.org/article/9a8bb329ba4246098107250f4606529c
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Hart et al. track newborn single cells by live microscopy after inducing a variety of nuclear atypia by CENP-E inhibitor treatment. They find that that multinucleation, unlike other forms of nuclear atypia, blocks proliferation independently of p53 a
Externí odkaz:
https://doaj.org/article/ad8b367f74aa42028c6ccf97367274c0
Autor:
Roshan L. Shrestha, Duccio Conti, Naoka Tamura, Dominique Braun, Revathy A. Ramalingam, Konstanty Cieslinski, Jonas Ries, Viji M. Draviam
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Human chromosomes are captured along microtubule walls and then tethered to microtubule-ends through a multi-step end-on conversion process. Here the authors show that Aurora-B regulates end-on conversion in human cells and establish a late role for
Externí odkaz:
https://doaj.org/article/f9f5bd0b1aa64801bac6724611b10ea2
Autor:
Madeleine Hart, Ihsan Zulkipli, Roshan Lal Shrestha, David Dang, Duccio Conti, Parveen Gul, Izabela Kujawiak, Viji M. Draviam
Publikováno v:
Open Biology, Vol 9, Iss 6 (2019)
Tissue maintenance and development requires a directed plane of cell division. While it is clear that the division plane can be determined by retraction fibres that guide spindle movements, the precise molecular components of retraction fibres that c
Externí odkaz:
https://doaj.org/article/2d31122027974458af536e9b594e78c6
Autor:
Naoka Tamura, Judith E. Simon, Arnab Nayak, Rajesh Shenoy, Noriko Hiroi, Viviane Boilot, Akira Funahashi, Viji M. Draviam
Publikováno v:
Biology Open, Vol 4, Iss 2, Pp 155-169 (2015)
Microtubules execute diverse mitotic events that are spatially and temporally separated; the underlying regulation is poorly understood. By combining drug treatments, large-scale immunoprecipitation and mass spectrometry, we report the first comprehe
Externí odkaz:
https://doaj.org/article/2c08ba19e6e845b79bffea4e5e371e69
Publikováno v:
Open Biology, Vol 4, Iss 6 (2014)
Chromosomal instability can arise from defects in chromosome–microtubule attachment. Using a variety of drug treatments, we show that TAO1 kinase is required for ensuring the normal congression of chromosomes. Depletion of TAO1 reduces the density
Externí odkaz:
https://doaj.org/article/61bb1f90078d4b208b28003bda7fd33c
Autor:
Naoka Tamura, Viji M. Draviam
Publikováno v:
Open Biology, Vol 2, Iss 11 (2012)
The microtubule polymer grows and shrinks predominantly from one of its ends called the ‘plus-end’. Plus-end regulation during interphase is well understood. However, mitotic regulation of plus-ends is only beginning to be understood in mammalian
Externí odkaz:
https://doaj.org/article/6113ef5aa7cd41d391e343bf36db3d68
Autor:
Duccio Conti, Parveen Gul, Asifa Islam, José M Martín-Durán, Richard W Pickersgill, Viji M Draviam
Publikováno v:
eLife, Vol 8 (2019)
Microtubules segregate chromosomes by attaching to macromolecular kinetochores. Only microtubule-end attached kinetochores can be pulled apart; how these end-on attachments are selectively recognised and stabilised is not known. Using the kinetochore
Externí odkaz:
https://doaj.org/article/489356cd9c3a4389a1d2ae2eb1ef6539
Autor:
David Dang, Christoforos Efstathiou, Dijue Sun, Haoran Yue, Nishanth R. Sastry, Viji M. Draviam
Publikováno v:
Journal of Cell Biology. 222
Time-lapse microscopy movies have transformed the study of subcellular dynamics. However, manual analysis of movies can introduce bias and variability, obscuring important insights. While automation can overcome such limitations, spatial and temporal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3ee954f5c8d417166be4493e6eb8771
https://doi.org/10.1083/jcb.202111094
https://doi.org/10.1083/jcb.202111094