Zobrazeno 1 - 10
of 364
pro vyhledávání: '"Viji M"'
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109007- (2024)
Summary: Chromosomal instability (CIN) is a hallmark of cancers, and CIN-promoting mutations are not fully understood. Here, we report 141 chromosomal instability aiding variant (CIVa) candidates by assessing the prevalence of loss-of-function (LoF)
Externí odkaz:
https://doaj.org/article/1e0e32715fda4fc48c04d567eae83dec
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Chromosome instability frequently occurs due to issues with chromosome-microtubule attachments. Here the authors show that the Astrin-PP1 and Cyclin-B-CDK1 pathways counteract each other to protect chromosome-microtubule attachments independent of bi
Externí odkaz:
https://doaj.org/article/9a8bb329ba4246098107250f4606529c
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
Hart et al. track newborn single cells by live microscopy after inducing a variety of nuclear atypia by CENP-E inhibitor treatment. They find that that multinucleation, unlike other forms of nuclear atypia, blocks proliferation independently of p53 a
Externí odkaz:
https://doaj.org/article/ad8b367f74aa42028c6ccf97367274c0
Autor:
Duccio Conti, Parveen Gul, Asifa Islam, José M Martín-Durán, Richard W Pickersgill, Viji M Draviam
Publikováno v:
eLife, Vol 8 (2019)
Microtubules segregate chromosomes by attaching to macromolecular kinetochores. Only microtubule-end attached kinetochores can be pulled apart; how these end-on attachments are selectively recognised and stabilised is not known. Using the kinetochore
Externí odkaz:
https://doaj.org/article/489356cd9c3a4389a1d2ae2eb1ef6539
Autor:
Roshan L. Shrestha, Duccio Conti, Naoka Tamura, Dominique Braun, Revathy A. Ramalingam, Konstanty Cieslinski, Jonas Ries, Viji M. Draviam
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Human chromosomes are captured along microtubule walls and then tethered to microtubule-ends through a multi-step end-on conversion process. Here the authors show that Aurora-B regulates end-on conversion in human cells and establish a late role for
Externí odkaz:
https://doaj.org/article/f9f5bd0b1aa64801bac6724611b10ea2
Autor:
Madeleine Hart, Ihsan Zulkipli, Roshan Lal Shrestha, David Dang, Duccio Conti, Parveen Gul, Izabela Kujawiak, Viji M. Draviam
Publikováno v:
Open Biology, Vol 9, Iss 6 (2019)
Tissue maintenance and development requires a directed plane of cell division. While it is clear that the division plane can be determined by retraction fibres that guide spindle movements, the precise molecular components of retraction fibres that c
Externí odkaz:
https://doaj.org/article/2d31122027974458af536e9b594e78c6
With the growth of artificial intelligence (AI), there has been an increase in the adoption of computer vision and deep learning (DL) techniques for the evaluation of microscopy images and movies. This adoption has not only addressed hurdles in quant
Externí odkaz:
http://arxiv.org/abs/2307.10500
Autor:
Naoka Tamura, Judith E. Simon, Arnab Nayak, Rajesh Shenoy, Noriko Hiroi, Viviane Boilot, Akira Funahashi, Viji M. Draviam
Publikováno v:
Biology Open, Vol 4, Iss 2, Pp 155-169 (2015)
Microtubules execute diverse mitotic events that are spatially and temporally separated; the underlying regulation is poorly understood. By combining drug treatments, large-scale immunoprecipitation and mass spectrometry, we report the first comprehe
Externí odkaz:
https://doaj.org/article/2c08ba19e6e845b79bffea4e5e371e69
Publikováno v:
Frontiers in Physiology, Vol 7 (2016)
Externí odkaz:
https://doaj.org/article/9e179f3975ba49a2bd55255f2e5328c3
Autor:
Francesco Iorio, Roshan L Shrestha, Nicolas Levin, Viviane Boilot, Mathew J Garnett, Julio Saez-Rodriguez, Viji M Draviam
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0139446 (2015)
We present a novel strategy to identify drug-repositioning opportunities. The starting point of our method is the generation of a signature summarising the consensual transcriptional response of multiple human cell lines to a compound of interest (na
Externí odkaz:
https://doaj.org/article/1fdd1d96dc5d4799a179fa8f1bb6ea4c