Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Vijaykumar Karuppiah"'
Autor:
Andrew Poole, Vijaykumar Karuppiah, Annabelle Hartt, Jaafar N. Haidar, Sylvie Moureau, Tomasz Dobrzycki, Conor Hayes, Christopher Rowley, Jorge Dias, Stephen Harper, Keir Barnbrook, Miriam Hock, Charlotte Coles, Wei Yang, Milos Aleksic, Aimee Bence Lin, Ross Robinson, Joe D. Dukes, Nathaniel Liddy, Marc Van der Kamp, Gregory D. Plowman, Annelise Vuidepot, David K. Cole, Andrew D. Whale, Chandramouli Chillakuri
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Cancers often harbor mutations in genes encoding important regulatory proteins, but therapeutic targeting of these molecules proves difficult due to their high structural similarity to their non-mutated counterpart. Here authors show the engineering
Externí odkaz:
https://doaj.org/article/d2f84672e7fe4eb3b7df368784cf9d36
Autor:
David Cole, Annelise Vuidepot, Andrew Whale, Andrew Poole, Vijaykumar Karuppiah, Annabelle Hartt, Jaafar Haidar, Sylvie Moureau, Aimee Bence Lin, Marc Van der Kamp, Gregory Plowman, Chandramouli Chillakuri
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/f88c19af0c8e4b699fedf005b648101c
Autor:
Mohd Zulkifli Salleh, Vijaykumar Karuppiah, Matthew Snee, Angela Thistlethwaite, Colin W. Levy, David Knight, Jeremy P. Derrick
Publikováno v:
mBio, Vol 10, Iss 3 (2019)
ABSTRACT Natural competence is the term used to describe the uptake of “naked” extracellular DNA by bacteria; it plays a significant role in horizontal genetic exchange. It is associated with type IV pili, and specialized competence pili mediate
Externí odkaz:
https://doaj.org/article/659fe2932b8743b2a327295f116a2110
Autor:
Claire Barber, Victoria Arena De Souza, Rachel L. Paterson, Magdalena Martin‐Urdiroz, Nitha Charles Mulakkal, Velupillai Srikannathasan, Mary Connolly, Gwilym Phillips, Tein Foong‐Leong, Robert Pengelly, Vijaykumar Karuppiah, Tressan Grant, Marcin Dembek, Anil Verma, Dawn Gibbs‐Howe, Thomas H. Blicher, Andrew Knox, Ross A. Robinson, David K. Cole, Sarah Leonard
Publikováno v:
European Journal of Immunology. 52:618-632
The nonpolymorphic class Ib molecule, HLA-E, primarily presents peptides from HLA class Ia leader peptides, providing an inhibitory signal to NK cells via CD94/NKG2 interactions. Although peptides of pathogenic origin can also be presented by HLA-E t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d151117755ecc5d2aa03be15d1548703
https://doi.org/10.1002/eji.202149745
https://doi.org/10.1002/eji.202149745
Autor:
Andrew, Poole, Vijaykumar, Karuppiah, Annabelle, Hartt, Jaafar N, Haidar, Sylvie, Moureau, Tomasz, Dobrzycki, Conor, Hayes, Christopher, Rowley, Jorge, Dias, Stephen, Harper, Keir, Barnbrook, Miriam, Hock, Charlotte, Coles, Wei, Yang, Milos, Aleksic, Aimee Bence, Lin, Ross, Robinson, Joe D, Dukes, Nathaniel, Liddy, Marc, Van der Kamp, Gregory D, Plowman, Annelise, Vuidepot, David K, Cole, Andrew D, Whale, Chandramouli, Chillakuri
Publikováno v:
Nature communications. 13(1)
Neoantigens derived from somatic mutations are specific to cancer cells and are ideal targets for cancer immunotherapy. KRAS is the most frequently mutated oncogene and drives the pathogenesis of several cancers. Here we show the identification and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::09b6f49fe5f2b3f9dd982b4e6d4e47e8
https://pubmed.ncbi.nlm.nih.gov/36088370
https://pubmed.ncbi.nlm.nih.gov/36088370
Autor:
Annabelle Hartt, Andrew Whale, Jaafar N. Haidar, Gregory D. Plowman, Aimee Bence Lin, Andrew Poole, Marc W. van der Kamp, Annelise Vuidepot, Vijaykumar Karuppiah, David K. Cole, Sylvie Moureau, Chandramouli Chillakuri
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundKRAS is the most frequently mutated oncogene, yet mutant KRAS has historically been a challenging target for conventional small molecule drug development. Tumour specific neoantigen peptides derived from KRAS are presented by cell surface h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ba4352c6c5f6c891c8975e1809ddab
https://doi.org/10.1136/jitc-2021-sitc2021.882
https://doi.org/10.1136/jitc-2021-sitc2021.882
Autor:
Nicole Prandi, Helen S. Toogood, David Leys, Eriko Takano, Nigel S. Scrutton, Vijaykumar Karuppiah, Lewis J. Kearsey, Cunyu Yan
Publikováno v:
The Febs Journal
Kearsey, L J, Prandi, N, Karuppiah, V, Yan, C, Leys, D, Toogood, H, Takano, E & Scrutton, N S 2019, ' Structure of the Cannabis sativa olivetol-producing enzyme reveals cyclization plasticity in type III polyketide synthases ', FEBS Journal . https://doi.org/10.1111/febs.15089
Kearsey, L J, Prandi, N, Karuppiah, V, Yan, C, Leys, D, Toogood, H, Takano, E & Scrutton, N S 2019, ' Structure of the Cannabis sativa olivetol-producing enzyme reveals cyclization plasticity in type III polyketide synthases ', FEBS Journal . https://doi.org/10.1111/febs.15089
In the native pathway to therapeutic cannabinoid biosynthesis in Cannabis sativa, the three‐step production of a key intermediate, olivetolic acid, is catalysed by the enzymes tetraketide synthase (TKS; linear tetraketide intermediate production in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7848e26c8de164acb8f86ae34bacd2
https://pubmed.ncbi.nlm.nih.gov/31605668
https://pubmed.ncbi.nlm.nih.gov/31605668
Autor:
Antonios Lygidakis, Vijaykumar Karuppiah, Robin Hoeven, Aisling Ní Cheallaigh, David Leys, John M. Gardiner, Helen S. Toogood, Nigel S. Scrutton
Publikováno v:
Angewandte Chemie (Weinheim an Der Bergstrasse, Germany)
Angewandte Chemie (International Ed. in English)
Lygidakis, A, Karuppiah, V, Hoeven, R, Ni Cheallaigh, A, Leys, D, Gardiner, J, Toogood, H & Scrutton, N 2016, ' Pinpointing a mechanistic switch between ketoreduction and ‘ene’-reduction in short chain dehydrogenases/reductases ', Angewandte Chemie, vol. 55, no. 33, pp. 9596-9600 . https://doi.org/10.1002/anie.201603785
Angewandte Chemie (International Ed. in English)
Lygidakis, A, Karuppiah, V, Hoeven, R, Ni Cheallaigh, A, Leys, D, Gardiner, J, Toogood, H & Scrutton, N 2016, ' Pinpointing a mechanistic switch between ketoreduction and ‘ene’-reduction in short chain dehydrogenases/reductases ', Angewandte Chemie, vol. 55, no. 33, pp. 9596-9600 . https://doi.org/10.1002/anie.201603785
Three enzymes of the Mentha essential oil biosynthetic pathway are highly homologous, namely the ketoreductases (−)‐menthone:(−)‐menthol reductase and (−)‐menthone:(+)‐neomenthol reductase, and the “ene” reductase isopiperitenone re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc61db01f49c59e68705bf86df723c3
http://europepmc.org/articles/PMC4988499
http://europepmc.org/articles/PMC4988499
Autor:
Marc W. van der Kamp, Vijaykumar Karuppiah, Adrian J. Mulholland, Kara E. Ranaghan, Andrew Currin, Nicole G. H. Leferink, Nigel S. Scrutton
Publikováno v:
Leferink, N, Ranaghan, K E, Karuppiah, V, Currin, A, van der Camp, M W, Mulholland, A J & Scrutton, N 2018, ' Experiment and Simulation Reveal How Mutations in Functional Plasticity Regions Guide Plant Monoterpene Synthase Product Outcome ', ACS Catalysis, vol. 8, no. 5, pp. 3780-3791 . https://doi.org/10.1021/acscatal.8b00692
Leferink, N G H, Ranaghan, K E, Karuppiah, V, Currin, A, Van Der Kamp, M W, Mulholland, A J & Scrutton, N S 2018, ' Experiment and Simulation Reveal How Mutations in Functional Plasticity Regions Guide Plant Monoterpene Synthase Product Outcome ', ACS Catalysis, vol. 8, no. 5, pp. 3780-3791 . https://doi.org/10.1021/acscatal.8b00692
Leferink, N G H, Ranaghan, K E, Karuppiah, V, Currin, A, Van Der Kamp, M W, Mulholland, A J & Scrutton, N S 2018, ' Experiment and Simulation Reveal How Mutations in Functional Plasticity Regions Guide Plant Monoterpene Synthase Product Outcome ', ACS Catalysis, vol. 8, no. 5, pp. 3780-3791 . https://doi.org/10.1021/acscatal.8b00692
Monoterpenes (C10 isoprenoids) are a structurally diverse group of natural compounds that are attractive to industry as flavors and fragrances. Monoterpenes are produced from a single linear substrate, geranyl diphosphate, by a group of enzymes calle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c11d440979cbf563a86031791e2b594
https://doi.org/10.1021/acscatal.8b00692
https://doi.org/10.1021/acscatal.8b00692
Autor:
Syed T. Ahmed, Gabriel A. Ascue Avalos, Adrian J. Mulholland, Reynier Suardíaz, Natalie Fey, Vijaykumar Karuppiah, Hanan L. Messiha, Stephen G. Yeates, Helen S. Toogood, Nigel S. Scrutton
Publikováno v:
Messiha, H L, Ahmed, S T, Karuppiah, V, Suardiaz, R, Ascue Avalos, G A, Fey, N, Yeates, S, Toogood, H S, Mulholland, A J & Scrutton, N S 2018, ' Biocatalytic Routes to Lactone Monomers for Polymer Production ', Biochemistry, vol. 57, no. 13, pp. 1997-2008 . https://doi.org/10.1021/acs.biochem.8b00169
Messiha, H L, Ahmed, S T, Karuppiah, V, Suardíaz, R, Ascue Avalos, G A, Fey, N, Yeates, S, Toogood, H S, Mulholland, A J & Scrutton, N S 2018, ' Biocatalytic routes to lactone monomers for polymer production ', Biochemistry, vol. 57, no. 13, pp. 1997-2008 . https://doi.org/10.1021/acs.biochem.8b00169
Messiha, H, Ahmed, S, Karuppiah, V, Suardiaz, R, Ascue Avalos, G, Fey, N, Yeates, S, Toogood, H, Mulholland, A J & Scrutton, N 2018, ' Biocatalytic Routes to Lactone Monomers for Polymer Production ', Biochemistry . https://doi.org/10.1021/acs.biochem.8b00169
Messiha, H L, Ahmed, S T, Karuppiah, V, Suardíaz, R, Ascue Avalos, G A, Fey, N, Yeates, S, Toogood, H S, Mulholland, A J & Scrutton, N S 2018, ' Biocatalytic routes to lactone monomers for polymer production ', Biochemistry, vol. 57, no. 13, pp. 1997-2008 . https://doi.org/10.1021/acs.biochem.8b00169
Messiha, H, Ahmed, S, Karuppiah, V, Suardiaz, R, Ascue Avalos, G, Fey, N, Yeates, S, Toogood, H, Mulholland, A J & Scrutton, N 2018, ' Biocatalytic Routes to Lactone Monomers for Polymer Production ', Biochemistry . https://doi.org/10.1021/acs.biochem.8b00169
Monoterpenoids offer potential as biocatalytically derived monomer feedstocks for high-performance renewable polymers. We describe a biocatalytic route to lactone monomers menthide and dihydrocarvide employing Baeyer-Villiger monooxygenases (BVMOs) f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a480a2e7ffdd2f827c476908d64730fe
https://research-information.bris.ac.uk/ws/files/155754971/BVMO_manuscript_biochemistry_12_03_18.pdf
https://research-information.bris.ac.uk/ws/files/155754971/BVMO_manuscript_biochemistry_12_03_18.pdf