Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Vijaykumar Deore"'
Autor:
Veena R. Agarwal, Somesh Sharma, Avinash More, Anagha Damre, Rajiv Sharma, Sanjay Kumar, Nilambari Yewalkar, Vijaykumar Deore, Lakshmi S. Kolla, Julie Bose, Sarika Chaudhari, Nikesh Desai, Magesh Venkatraman, Asavari Joshi, Srinivas Boreddy, Dimple R. Bhatia, Archana Jalota-Badhwar
Supplementary Table S1; Supplementary Figures S1-S2. Supplementary Table 1. A) IC50 value of P7170 in pan-PI3K. B) Kinase inhibition data (ProQinase) of P7170 at 250 nM and 1. 5 μM.C) Kinase inhibition profile (KINOMEscan; 320 kinases) of P717
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25173fc0ee98eb8b60c1909b4e3f991
https://doi.org/10.1158/1535-7163.22502247.v1
https://doi.org/10.1158/1535-7163.22502247.v1
Autor:
Asavari Joshi, Anagha Damre, Veena R Agarwal, Magesh Venkatraman, Rajiv Sharma, Nikesh Desai, Julie Bose, Srinivas Reddy Boreddy, Lakshmi Sireesha Kolla, Nilambari Yewalkar, Archana Jalota-Badhwar, Sarika Chaudhari, Avinash More, Vijaykumar Deore, Somesh Sharma, Dimple Bhatia, Sanjay Kumar
Publikováno v:
Molecular Cancer Therapeutics. 14:1095-1106
The mTOR pathway is often upregulated in cancer and thus intensively pursued as a target to design novel anticancer therapies. Approved and emerging drugs targeting the mTOR pathway have positively affected the clinical landscape. Recently, activin r
Autor:
Mandar R. Bhonde, Kalpana Joshi, Vijaykumar Deore, Nikesh Desai, Amol Padgaonkar, Asavari Joshi, Anagha Damre, Pradeep Kumar, Manoj V. Lohar, Pallavi Godse, Ramswaroop Mundada, Dimple Bhatia, Rajiv Sharma, Nilambari Yewalkar, Sanjay Kumar, Sonal M Manohar
Publikováno v:
Anti-Cancer Agents in Medicinal Chemistry. 13:1460-1466
Hypoxia-inducible factor-1α (HIF-1α) and signal transducer and activator of transcription 3 (STAT3) are transcription factors and are activated in response to hypoxia. Both HIF-1α and STAT3 regulate various aspects of cancer biology such as cell s
Autor:
Abhijit Roychowdhury, Ram A. Vishwakarma, Vijaykumar Deore, Manoj Kumar Lohar, Ramswaroop Mundada, Sanjeev Kumar
Publikováno v:
Synthetic Communications. 41:177-183
Liphagal (A) is a very potent and selective inhibitor of PI3Kα (p110α) and is under development for an oncolytic drug. We herein report the new and concise synthesis of key intermediates (7, 8), which have been used for liphagal synthesis and will
Autor:
Ramswaroop Mundada, Seema Ranaware, Sanjeev Kumar, Manoj V. Lohar, Vijaykumar Deore, Nilambari Yewalkar
Publikováno v:
Journal of Heterocyclic Chemistry. 44:495-498
We are herein reporting the regioselective synthesis of quinazoline containing novel monoaryl ethers (quinazoline-O-Ar) (3a-3j) at room temperature without any catalyst. From commercially available 2,4-dichloro-6,7-dimethoxyquinazoline (1), 4-chloro
Autor:
Vinay Sonawane, Dimple Bhatia, Prashant Tannu, Veena R Agarwal, Vaibhavi J Lad, Prashant Pandey, Somesh Sharma, Magesh Venkataraman, Ankita Srivastava, Venkatasubbaiah A. Venkatesha, Vijaykumar Deore, Ramachandra Sangana, Asavari Joshi, Tausif Ahmed, Anagha Damre, Sarika Choudhari, Julie Bose, Bichismita Sahu, Sanjay Kumar
Publikováno v:
Molecular Cancer
Background Lung cancer is the major cause of cancer-related deaths and many cases of Non Small Cell Lung Cancer (NSCLC), a common type of lung cancer, have frequent genetic/oncogenic activation of EGFR, KRAS, PIK3CA, BRAF, and others that drive tumor
Autor:
Pallavi, Godse, Pramod, Kumar, Nilambari, Yewalkar, Vijaykumar, Deore, Manoj, Lohar, Ramswaroop, Mundada, Amol, Padgaonkar, Sonal, Manohar, Asavari, Joshi, Dimple, Bhatia, Nikesh, Desai, Anagha, Damre, Mandar, Bhonde, Kalpana, Joshi, Rajiv, Sharma, Sanjay, Kumar
Publikováno v:
Anti-cancer agents in medicinal chemistry. 13(9)
Hypoxia-inducible factor-1α (HIF-1α) and signal transducer and activator of transcription 3 (STAT3) are transcription factors and are activated in response to hypoxia. Both HIF-1α and STAT3 regulate various aspects of cancer biology such as cell s
Autor:
Abhijit Roychowdhury, Manoj Kumar Lohar, Vijaykumar Deore, Ram A. Vishwakarma, Ramswaroop Mundada, Sanjeev Kumar
Publikováno v:
ChemInform. 42
A facile method for the synthesis of the key intermediates (VI) and (VII) is presented starting from the inexpensive and readily available starting material 2,4,5-trimethoxy benzaldehyde.
Autor:
Pramod Kumar, Kalpana Joshi, Amol Padgaonkar, Bichismita Sahu, Archana Jalota-Badhwar, Sonal M Manohar, Somesh Sharma, Sanjeev Kumar, Nilambari Yewalkar, Vijaykumar Deore
Publikováno v:
ChemInform. 42
Pyridylpyrimidine based potent and selective inhibitors of HIF-1α are designed and synthesized.
Autor:
Kalpana Joshi, Somesh Sharma, Nilambari Yewalkar, Amol Padgaonkar, Vijaykumar Deore, Pramod Kumar, Sanjeev Kumar, Archana Jalota-Badhwar, Bichismita Sahu, Sonal M Manohar
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(22)
Hypoxia-inducible factor-1α (HIF-1α) is a critical regulatory protein of cellular response to hypoxia, and regulates the transcription of many genes involved in key aspects of cancer biology, including immortalization, maintenance of stem cell pool