Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Vijayalakshmi V Subramanian"'
Autor:
Vijayalakshmi V Subramanian, Amy J MacQueen, Gerben Vader, Miki Shinohara, Aurore Sanchez, Valérie Borde, Akira Shinohara, Andreas Hochwagen
Publikováno v:
PLoS Biology, Vol 14, Iss 2, p e1002369 (2016)
Faithful meiotic chromosome segregation and fertility require meiotic recombination between homologous chromosomes rather than the equally available sister chromatid, a bias that in Saccharomyces cerevisiae depends on the meiotic kinase, Mek1. Mek1 i
Externí odkaz:
https://doaj.org/article/141ebd8dfab941adba2cab87cd222617
Autor:
Karen Voelkel-Meiman, Cassandra Johnston, Yashna Thappeta, Vijayalakshmi V Subramanian, Andreas Hochwagen, Amy J MacQueen
Publikováno v:
PLoS Genetics, Vol 11, Iss 6, p e1005335 (2015)
Accurate chromosome segregation during meiosis relies on the presence of crossover events distributed among all chromosomes. MutSγ and MutLγ homologs (Msh4/5 and Mlh1/3) facilitate the formation of a prominent group of meiotic crossovers that matur
Externí odkaz:
https://doaj.org/article/2923414275ed46a69e2db6b65ebad7a1
Publikováno v:
PLoS Genetics, Vol 4, Iss 11, p e1000263 (2008)
In humans, meiotic chromosome segregation errors increase dramatically as women age, but the molecular defects responsible are largely unknown. Cohesion along the arms of meiotic sister chromatids provides an evolutionarily conserved mechanism to kee
Externí odkaz:
https://doaj.org/article/fe9df98e9c8c46ada4dbb0867dc8ee9e
Autor:
Vijayalakshmi V. Subramanian
Publikováno v:
Molecular Biology of the Cell. 34
Cohesins organize chromatin within the nucleus by promoting loop extrusion via cis contacts on chromatin and sister chromatid cohesion via trans contacts between chromatids. Whether cohesins employ a distinct mechanism for these two functions is not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c652f75cf2fc2c63b913fcc147c52839
https://doi.org/10.1091/mbc.p23-03-0010
https://doi.org/10.1091/mbc.p23-03-0010
Autor:
Vijayalakshmi V. Subramanian
Publikováno v:
Molecular Biology of the Cell. 34
Age-dependent loss of cohesion is a determinant of aneuploidy in human oocytes. Mechanisms for how this loss is triggered with age are not known. Using oocytes from human participants of various ages, the authors correlate loss of Sgo2, a protector o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d55b6673c0a79e65d2ea6daeaa9ccafa
https://doi.org/10.1091/mbc.p23-04-0011
https://doi.org/10.1091/mbc.p23-04-0011
Programmed double strand DNA breaks in meiosis can be repaired as inter-homologue crossovers and thereby aid the faithful segregation of homologous chromosomes. Biased repair mechanisms enforce repair with the homologue. Further, DNA breaks left unre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6d5a5c66495cbc7f362ff281395fa0b
https://doi.org/10.1101/2023.04.01.535230
https://doi.org/10.1101/2023.04.01.535230
Autor:
Vijayalakshmi V. Subramanian
Publikováno v:
Molecular biology of the cell. 33(14)
Many commonly used protein epitope tags are optimized for one or a few biological applications. The recently developed ALFA tag performs well across a broad range of cell biological applications including localization, biochemical, and functional stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7322e256fe33dc093f236ce93fa82903
https://pubmed.ncbi.nlm.nih.gov/36413211
https://pubmed.ncbi.nlm.nih.gov/36413211
Autor:
Vijayalakshmi V. Subramanian
Publikováno v:
Molecular biology of the cell. 33(8)
Cohesins play an important role in organizing the meiotic chromosome structure, but how cohesins themselves are regulated during this process is not entirely clear. Taking advantage of conditional depletion, point mutations and quantitative immunoflu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7715fca3ba01604ed62f01b805076c76
https://pubmed.ncbi.nlm.nih.gov/35728078
https://pubmed.ncbi.nlm.nih.gov/35728078
Autor:
Yaroslav Terentyev, Vijayalakshmi V. Subramanian, Tomomi Tsubouchi, Bilge Argunhan, Negar Afshar, Hiroshi Iwasaki, Andreas Hochwagen, Wing Kit Leung, Hideo Tsubouchi, Yasuto Murayama
Publikováno v:
The EMBO Journal. 36(No. 17):2488-2509
The synaptonemal complex (SC) is a proteinaceous macromolecular assembly that forms during meiotic prophase I and mediates adhesion of paired homologous chromosomes along their entire lengths. Although prompt disassembly of the SC during exit from pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87af4e7a552de7e5262bbd4004e9eddc
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100784520
http://t2r2.star.titech.ac.jp/cgi-bin/publicationinfo.cgi?q_publication_content_number=CTT100784520
Autor:
Pedro A. San-Segundo, Scott Keeney, Andreas Hochwagen, Xuan Zhu, Luis Andre Vale Silva, Vijayalakshmi V. Subramanian, Tovah E. Markowitz, Nancy M. Hollingsworth
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname
Faithful meiotic chromosome inheritance and fertility rely on the stimulation of meiotic crossover recombination by potentially genotoxic DNA double-strand breaks (DSBs). To avoid excessive damage, feedback mechanisms down-regulate DSBs, likely in re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::327348abafc7552bcdc6702c53a7b88c
http://europepmc.org/articles/PMC6393486
http://europepmc.org/articles/PMC6393486