Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Vijayalakshmi N. Ayyagari"'
Autor:
Vijayalakshmi N Ayyagari, Xinjia Wang, Paula L Diaz-Sylvester, Kathleen Groesch, Laurent Brard
Publikováno v:
PLoS ONE, Vol 15, Iss 1, p e0228024 (2020)
Abnormal accumulation of acyl-CoA cholesterol acyltransferase-1 (ACAT-1) mediated cholesterol ester has been shown to contribute to cancer progression in various cancers including leukemia, glioma, breast, pancreatic and prostate cancers. However, th
Externí odkaz:
https://doaj.org/article/f272d5a44a8e47aaa4dd15af72adade1
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185111 (2017)
Previously, Bithionol (BT) was shown to enhance the chemosensitivity of ovarian cancer cell lines to cisplatin treatment. In the present study, we focused on the anti-tumor potential of the BT-paclitaxel combination when added to a panel of ovarian c
Externí odkaz:
https://doaj.org/article/201792763a7e420f9a553bc89c90f895
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0185111 (2017)
PLoS ONE
PLoS ONE
Previously, Bithionol (BT) was shown to enhance the chemosensitivity of ovarian cancer cell lines to cisplatin treatment. In the present study, we focused on the anti-tumor potential of the BT-paclitaxel combination when added to a panel of ovarian c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153a199c548c2704c3055c5932a90794
http://europepmc.org/articles/PMC5607185?pdf=render
http://europepmc.org/articles/PMC5607185?pdf=render
Publikováno v:
Cancer Research. 77:4416-4416
INTRODUCTION: Cancer progression and tumorigenesis have been linked to alterations in cellular metabolic pathways of lipid and cholesterol synthesis in many cancers. Increased levels of cholesterol esters (CE) have been reported in breast cancer, leu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bf886ab590149590079dbed411ad9dd
https://doi.org/10.1158/1538-7445.am2017-4416
https://doi.org/10.1158/1538-7445.am2017-4416
In terms of the concept of 'drug repurposing', we focused on pharmaceutical-grade Bithionol (BT) as a therapeutic agent against ovarian cancer. Our recent in-vitro study provides preclinical data suggesting a potential therapeutic role for BT against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78050e8e045f441cf71de49c77653038
https://europepmc.org/articles/PMC5053334/
https://europepmc.org/articles/PMC5053334/
Publikováno v:
Inhalation Toxicology. 19:181-194
Nitrogen Dioxide (NO2) is a product of high-temperature combustion and an environmental oxidant of concern. We have recently reported that early changes in NO2-exposed human bronchial epithelial cells are causally linked to increased generation of pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26997e06dfdf795b538c827596d363b1
https://doi.org/10.1080/08958370601052121
https://doi.org/10.1080/08958370601052121
Publikováno v:
Experimental and Molecular Pathology. 80:11-25
To monitor cascade of events following alveolar extravasation of blood due to exposure to shock wave (SW), we conducted spatiotemporal assessment of myeloperoxidase (MPO), heme oxygenase 1 (HO-1), Cu,Zn superoxide dismutase (SOD-1), transferrin (TRF)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e9f18dfee316e2c3b8c6c520e3a202
https://doi.org/10.1016/j.yexmp.2005.06.007
https://doi.org/10.1016/j.yexmp.2005.06.007
Publikováno v:
Toxicology. 197:148-163
Nitrogen dioxide (NO2) is an environmental oxidant, known to be associated with lung epithelial injury. In the present study, cellular pro-inflammatory responses following exposure to a brief high concentration of NO2 (45 ppm) were assessed, using no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33efc7d8bb6bb77f7360995b10b41760
https://doi.org/10.1016/j.tox.2003.12.017
https://doi.org/10.1016/j.tox.2003.12.017
Publikováno v:
BMC Cancer
Background Drug resistance is a cause of ovarian cancer recurrence and low overall survival rates. There is a need for more effective treatment approaches because the development of new drug is expensive and time consuming. Alternatively, the concept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8b2e51e748e1885e7d0021f15bd76e1
https://doi.org/10.1186/1471-2407-14-61
https://doi.org/10.1186/1471-2407-14-61
Publikováno v:
Cancer Research. 73:2121-2121
Introduction: ‘Drug Repurposing’ promises to be a successful concept for the treatment of many diseases. We focused on Bithionol (BT), a clinically approved antiparasitic drug for use as a therapeutic agent against ovarian cancer. BT has been sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10b5fa884d7f106970e16fef87cd9206
https://doi.org/10.1158/1538-7445.am2013-2121
https://doi.org/10.1158/1538-7445.am2013-2121